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NAA10 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204403
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NAA10, Recombinant Protein

 Also Known As   

NAA10, 1-235aa, Human, His tag, E Coli

 Product Synonym Names    N (alpha)-acetyltransferase 10; NatA catalytic subunit; ARD1; ARD1A; DXS707; MGC71248; TE2
 Product Gene Name   

NAA10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDENG KIVGYVLAKM EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRAALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LTQMADELRR HLELKEKGRH VVLGAIENKV ESKGNSPPSS GEACREEKGL AAEDSGGDSK DLSEVSETTE STDVKDSSEA SDSAS
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 10% glycerol, 200mM NaCl
 Concentration    1mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NAA10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NAA10 recombinant protein

   NAA10 belongs to the acetyltransferase family. NAA10 interacts NAA15, HIF-1 with the ribosome. In its binding to HIF-1, NAA10 acts as a protein acetyltransferase by regulating its stability. In many cell lines, NAA10 is downregulated in response to hypoxia. NAA10 is expressed throughout the development of the brain. Recombinant human NAA10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for NAA10 recombinant protein    Metabolism
 Applications Tested/Suitable for NAA10 recombinant protein   

SDS-PAGE

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 SDS-PAGE of NAA10 recombinant protein    NAA10 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for NAA10. It may not necessarily be applicable to this product.
 NCBI GI #    10835057
 NCBI GeneID    8260
 NCBI Accession #    NP_003482 [Other Products]
 NCBI GenBank Nucleotide #    NM_003491.3 [Other Products]
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 UniProt Secondary Accession #    A6NM98 [Other Products]
 UniProt Related Accession #    P41227 [Other Products]
 Molecular Weight    28.6kDa (255aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    N-alpha-acetyltransferase 10 isoform 1
 NCBI Official Synonym Full Names    N(alpha)-acetyltransferase 10, NatA catalytic subunit
 NCBI Official Symbol    NAA10 [Similar Products]
 NCBI Official Synonym Symbols   
TE2; ARD1; NATD; ARD1A; ARD1P; DXS707; MCOPS1
[Similar Products]
 NCBI Protein Information    N-alpha-acetyltransferase 10; ARD1 homolog A, N-acetyltransferase; N-acetyltransferase ARD1, human homolog of; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A; natA catalytic subunit Naa10
 UniProt Protein Name    N-alpha-acetyltransferase 10
 UniProt Synonym Protein Names   
N-terminal acetyltransferase complex ARD1 subunit homolog A; NatA catalytic subunit Naa10
 Protein Family    N-alpha-acetyltransferase
 UniProt Gene Name    NAA10 [Similar Products]
 UniProt Synonym Gene Names    ARD1; ARD1A; TE2 [Similar Products]
 UniProt Entry Name    NAA10_HUMAN
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 NCBI Summary for NAA10    N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for NAA10    NAA10: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily.

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Acetyltransferase; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: membrane; cytoplasm; nucleolus; intracellular; nucleus

Molecular Function: peptide alpha-N-acetyltransferase activity; N-acetyltransferase activity; protein binding; acetyltransferase activity; ribosome binding

Biological Process: N-terminal protein amino acid acetylation; N-terminal peptidyl-glutamic acid acetylation; internal protein amino acid acetylation; DNA packaging; N-terminal peptidyl-serine acetylation

Disease: Ogden Syndrome; Microphthalmia, Syndromic 1
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Product References and Citations for NAA10 recombinant protein

   Arnesen T., et al. (2005) Biochem. J. 386:433-443
Jeong J.-W., et al. (2002) Cell 111:709-720
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 Research Articles on NAA10    1. The study concludes that the NAA10 mutation is the cause of Lenz microphthalmia syndrome in a family, likely through the dysregulation of the retinoic acid signalling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NAA10 recombinant proteinPathways associated with NAA10 recombinant protein
 Reference Product  PubMed Publications
 HIF1A recombinant protein  >10 publications with NAA10 and HIF1A
 NAT1 recombinant protein  >5 publications with NAA10 and NAT1
 NAA15 recombinant protein  >4 publications with NAA10 and NAA15
 L1CAM recombinant protein  >3 publications with NAA10 and L1CAM
 AVPR2 recombinant protein  >2 publications with NAA10 and AVPR2
 RENBP recombinant protein  >1 publications with NAA10 and RENBP
 Products by Pathway  Pathway Diagram
 Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway antibodies  Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway Diagram
Diseases associated with NAA10 recombinant proteinOrgans/Tissues associated with NAA10 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >2 publications with NAA10 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >2 publications with NAA10 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with NAA10 and Liver Diseases
 Prostatic Diseases Antibodies  >2 publications with NAA10 and Prostatic Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with NAA10 and Urinary Bladder Neoplasms
 Hyperplasia Antibodies  >1 publications with NAA10 and Hyperplasia
 Liver Neoplasms Antibodies  >1 publications with NAA10 and Liver Neoplasms
 Inflammation Antibodies  >1 publications with NAA10 and Inflammation
 Congenital Abnormalities Antibodies  >1 publications with NAA10 and Congenital Abnormalities
 Kidney Diseases Antibodies  >1 publications with NAA10 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with NAA10 and Lung
 Blood Antibodies  >4 publications with NAA10 and Blood
 Lymph Node Antibodies  >2 publications with NAA10 and Lymph Node
 Liver Antibodies  >2 publications with NAA10 and Liver
 Thyroid Antibodies  >2 publications with NAA10 and Thyroid
 Lymph Antibodies  >2 publications with NAA10 and Lymph
 Kidney Antibodies  >2 publications with NAA10 and Kidney
 Prostate Antibodies  >2 publications with NAA10 and Prostate
 Testis Antibodies  >1 publications with NAA10 and Testis
 Mammary Gland Antibodies  >1 publications with NAA10 and Mammary Gland
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