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NDuFS4 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203329
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NDuFS4, Recombinant Protein

 Also Known As   

NDuFS4, 43-175aa, Human, E Coli

 Product Synonym Names    NADH dehydrogenase (ubiquinone) Fe-S protein 4; AQDQ; NADH dehydrogenase (ubiquinone) Fe-S protein 4 CI 18 kDa; CI AQDQ; Complex I 18 kDa; Complex I AQDQ; mitochondrial respiratory chain complex I (18 KD subunit); NADH dehydrogenase; NADH ubiquinone oxidoreductase 18 kDa subunit.
 Product Gene Name   

NDuFS4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK
 OMIM    AF020351 mRNA
 3D Structure    ModBase 3D Structure for O43181
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 30% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NDuFS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NDuFS4 recombinant protein

   NDuFS4, also known as NADH dehydrogenase (ubiquinone) Fe-S protein 4, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. Recombinant human NDuFS4 protein was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for NDuFS4 recombinant protein    Metabolism
 Applications Tested/Suitable for NDuFS4 recombinant protein   

SDS-PAGE

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 SDS-Page of NDuFS4 recombinant protein    NDuFS4 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for NDuFS4. It may not necessarily be applicable to this product.
 NCBI GI #    4505369
 NCBI GeneID    4724
 NCBI Accession #    NP_002486 [Other Products]
 NCBI GenBank Nucleotide #    NM_002495.3 [Other Products]
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 UniProt Primary Accession #    O43181 [Other Products]
 UniProt Secondary Accession #    Q9BS69 [Other Products]
 UniProt Related Accession #    O43181 [Other Products]
 Molecular Weight    15.5 kDa (134aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    NADH dehydrogenase
 NCBI Official Synonym Full Names    NADH:ubiquinone oxidoreductase subunit S4
 NCBI Official Symbol    NDUFS4 [Similar Products]
 NCBI Official Synonym Symbols   
AQDQ; CI-18; CI-AQDQ; CI-18 kDa
[Similar Products]
 NCBI Protein Information    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
 UniProt Protein Name    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
 UniProt Synonym Protein Names   
Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit
 Protein Family    NADH dehydrogenase [ubiquinone] iron-sulfur protein
 UniProt Gene Name    NDUFS4 [Similar Products]
 UniProt Synonym Gene Names    CI-18 kDa; CI-AQDQ [Similar Products]
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 NCBI Summary for NDuFS4    This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for NDuFS4    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
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Product References and Citations for NDuFS4 recombinant protein

   Choi WS., et al. (2008), Proc Natl Acad Sci u S A. 105 (39):15136-41.; De Rasmo D., et al. (2008). Cell Signal. 20 (5):989-97.;
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 Research Articles on NDuFS4    1. The clinical presentations of five individuals of Hutterite descent with Leigh disease are described herein. An identity-by-descent mapping and candidate gene approach was used to identify a novel homozygous c.393dupA frameshift mutation in the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (NDUFS4) gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NDuFS4 recombinant proteinPathways associated with NDuFS4 recombinant protein
 Reference Product  PubMed Publications
 NDUFS2 recombinant protein  >8 publications with NDuFS4 and NDUFS2
 NDUFS8 recombinant protein  >7 publications with NDuFS4 and NDUFS8
 NDUFV2 recombinant protein  >5 publications with NDuFS4 and NDUFV2
 NDUFS3 recombinant protein  >3 publications with NDuFS4 and NDUFS3
 NDUFA12 recombinant protein  >2 publications with NDuFS4 and NDUFA12
 NDUFB7 recombinant protein  >2 publications with NDuFS4 and NDUFB7
 NDUFAB1 recombinant protein  >2 publications with NDuFS4 and NDUFAB1
 NDUFA2 recombinant protein  >1 publications with NDuFS4 and NDUFA2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Complex I Biogenesis Pathway antibodies  Complex I Biogenesis Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway antibodies  NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway Diagram
 NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway antibodies  NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway Diagram
Diseases associated with NDuFS4 recombinant proteinOrgans/Tissues associated with NDuFS4 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >47 publications with NDuFS4 and Nervous System Diseases
 Brain Diseases Antibodies  >43 publications with NDuFS4 and Brain Diseases
 Leigh Disease Antibodies  >33 publications with NDuFS4 and Leigh Disease
 Disease Models, Animal Antibodies  >25 publications with NDuFS4 and Disease Models, Animal
 Death Antibodies  >22 publications with NDuFS4 and Death
 Mitochondrial complex I deficiency Antibodies  >15 publications with NDuFS4 and Mitochondrial complex I deficiency
 Liver Diseases Antibodies  >4 publications with NDuFS4 and Liver Diseases
 Nerve Degeneration Antibodies  >3 publications with NDuFS4 and Nerve Degeneration
 Inflammation Antibodies  >3 publications with NDuFS4 and Inflammation
 Necrosis Antibodies  >3 publications with NDuFS4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >38 publications with NDuFS4 and Brain
 Muscle Antibodies  >20 publications with NDuFS4 and Muscle
 Heart Antibodies  >11 publications with NDuFS4 and Heart
 Liver Antibodies  >8 publications with NDuFS4 and Liver
 Blood Antibodies  >5 publications with NDuFS4 and Blood
 Lung Antibodies  >4 publications with NDuFS4 and Lung
 Skin Antibodies  >4 publications with NDuFS4 and Skin
 Eye Antibodies  >3 publications with NDuFS4 and Eye
 Kidney Antibodies  >2 publications with NDuFS4 and Kidney
 Vascular Antibodies  >2 publications with NDuFS4 and Vascular
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