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NGAL recombinant protein

Scan QR to view Datasheet Catalog #    MBS5304351 NGAL recombinant protein
Unit / Price
1 mL  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NGAL, Recombinant Protein

★Popular Item★
 Also Known As   

NGAL protein (Pig)

 Product Synonym Names    NNE protein; Neutrophil gelatinase-associated lipocalin protein; Lipocalin-2 protein; MSFI protein; Porcine NGAL protein; Oncogene 24p3 protein; p25 protein; HNL protein; LCN2 protein; LCN-2 protein; LCN 2; 2 phospho D glycerate hydrolyase protein; Phosphopyruvate hydratase protein; Plasminogen binding protein; alpha enolase protein; C myc promoter binding protein; Enolase 1 protein; MBP1 protein; Non neural enolase protein
 Product Gene Name   

NGAL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600181
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 Form/Format    Liquid in 0.01M Phosphate buffer, ph 7.4, with 0.14 NaCI, 0.5% BSA, 0.5% BSA, 0.5% Tween 20, 0.0016% Phenol red, and 0.1% Proclin 950
 Concentration    400 pg/mL (lot specific)
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 Source    E.coli
 Species    Pig
 Grade    Recombinant
 Biohazard    For research use only. Use standard laboratory precautions when handling.
 Assay Information    MBS5304351 can be used as a standard in NGAL quantifying assays, such as ELISA.
 Biohazard    For research use only. Use standard laboratory precautions when handling.
 Biological Significance    NGAL is expressed and secreted by immune cells, hepatocytes , and renal tubular cells in various pathalogic states. NAGAL exerts bacteriostatic effects, which are explained by its ability to capture and deplete siderohores, small iron-binding molecules that are syntesized by certain bacteria as a means of iron acquistion.
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 Preparation and Storage    Store at 4C
 Other Notes    Small volumes of NGAL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NGAL recombinant protein

   Purified recombinant Pig NGAL protein
 Product Categories/Family for NGAL recombinant protein    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for NGAL recombinant protein   

ELISA (EIA)

 Application Notes for NGAL recombinant protein    MBS5304351 can be used as a standard in NGAL quantifying assays, such as ELISA.
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NCBI/Uniprot data below describe general gene information for NGAL. It may not necessarily be applicable to this product.
 NCBI GI #    38455402
 NCBI GeneID    3934
 NCBI Accession #    NP_005555.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005564.3 [Other Products]
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 UniProt Secondary Accession #    P30150; Q5SYV9; Q5SYW0; Q6FGL5; Q92683; A6NII8; B4DWV4; B7ZAA2 [Other Products]
 UniProt Related Accession #    P80188 [Other Products]
 Molecular Weight    22,457 Da
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 NCBI Official Full Name    neutrophil gelatinase-associated lipocalin
 NCBI Official Synonym Full Names    lipocalin 2
 NCBI Official Symbol    LCN2 [Similar Products]
 NCBI Official Synonym Symbols   
24p3; MSFI; NGAL
[Similar Products]
 NCBI Protein Information    neutrophil gelatinase-associated lipocalin
 UniProt Protein Name    Neutrophil gelatinase-associated lipocalin
 UniProt Synonym Protein Names   
25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25
 UniProt Gene Name    LCN2 [Similar Products]
 UniProt Synonym Gene Names    HNL; NGAL; NGAL [Similar Products]
 UniProt Entry Name    NGAL_HUMAN
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 UniProt Comments for NGAL    LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding

Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport
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 Research Articles on NGAL    1. urinary NGAL is a sensitive biomarker for tacrolimus-induced AKI, and may help predict renal event caused by tacrolimus therapy in liver transplant patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NGAL recombinant proteinDiseases associated with NGAL recombinant protein
 Products by Pathway  Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >663 publications with NGAL and Kidney Diseases
 Acute Kidney Injury Antibodies  >603 publications with NGAL and Acute Kidney Injury
 Inflammation Antibodies  >302 publications with NGAL and Inflammation
 Cardiovascular Diseases Antibodies  >228 publications with NGAL and Cardiovascular Diseases
 Heart Diseases Antibodies  >119 publications with NGAL and Heart Diseases
 Necrosis Antibodies  >101 publications with NGAL and Necrosis
 Disease Models, Animal Antibodies  >95 publications with NGAL and Disease Models, Animal
 Proteinuria Antibodies  >95 publications with NGAL and Proteinuria
 Hypertension Antibodies  >74 publications with NGAL and Hypertension
 Liver Diseases Antibodies  >74 publications with NGAL and Liver Diseases
Organs/Tissues associated with NGAL recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >846 publications with NGAL and Blood
 Kidney Antibodies  >761 publications with NGAL and Kidney
 Liver Antibodies  >161 publications with NGAL and Liver
 Lung Antibodies  >78 publications with NGAL and Lung
 Bone Antibodies  >41 publications with NGAL and Bone
 Connective Tissue Antibodies  >40 publications with NGAL and Connective Tissue
 Muscle Antibodies  >38 publications with NGAL and Muscle
 Bone Marrow Antibodies  >32 publications with NGAL and Bone Marrow
 Intestine Antibodies  >26 publications with NGAL and Intestine
 Uterus Antibodies  >22 publications with NGAL and Uterus
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