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KLRC2 recombinant protein :: NKG2-C type II integral membrane Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955746
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NKG2-C type II integral membrane (KLRC2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human NKG2-C type II integral membrane protein

 Product Synonym Names    CD159 antigen-like family member CNK cell receptor CNKG2-C-activating NK receptor; CD159c
 Product Gene Name   

KLRC2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    94-231aa; Extracellular Domain
 Sequence    IPFLEQNNSS PNTRTQKARH CGHCPEEWIT YSNSCYYIGK ERRTWEESLL ACTSKNSSLL SIDNEEEMKF LASILPSSWI GVFRNSSHHP WVTINGLAFK HKIKDSDNAE LNCAVLQVNR LKSAQCGSSM IYHCKHKL
 OMIM    602891
 3D Structure    ModBase 3D Structure for P26717
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KLRC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KLRC2 recombinant protein

   Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
 Product Categories/Family for KLRC2 recombinant protein    Immunology
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 SDS-PAGE of KLRC2 recombinant protein    KLRC2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for KLRC2. It may not necessarily be applicable to this product.
 NCBI GI #    75709169
 NCBI GeneID    3822
 NCBI Accession #    NP_002251.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002260.3 [Other Products]
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 UniProt Primary Accession #    P26717 [Other Products]
 UniProt Secondary Accession #    O43802; Q52M74; Q9NR42 [Other Products]
 UniProt Related Accession #    P26717 [Other Products]
 Molecular Weight    31.78kD
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 NCBI Official Full Name    NKG2-C type II integral membrane protein
 NCBI Official Synonym Full Names    killer cell lectin like receptor C2
 NCBI Official Symbol    KLRC2 [Similar Products]
 NCBI Official Synonym Symbols   
NKG2C; CD159c; NKG2-C
[Similar Products]
 NCBI Protein Information    NKG2-C type II integral membrane protein
 UniProt Protein Name    NKG2-C type II integral membrane protein
 UniProt Synonym Protein Names   
CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; CD_antigen: CD159c
 Protein Family    NKG2-C type II integral membrane protein
 UniProt Gene Name    KLRC2 [Similar Products]
 UniProt Synonym Gene Names    NKG2C [Similar Products]
 UniProt Entry Name    NKG2C_HUMAN
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 NCBI Summary for KLRC2    Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KLRC2    KLRC2: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: carbohydrate binding; protein binding; transmembrane receptor activity

Biological Process: cellular defense response; innate immune response; natural killer cell mediated immunity; signal transduction
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Product References and Citations for KLRC2 recombinant protein

   DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.Houchins J.P., Yabe T., McSherry C., Bach F.H.J. Exp. Med. 173:1017-1020(1991) The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F.Immunogenetics 48:163-173(1998) Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P.J. Immunol. 168:240-252(2002) Biassoni R. The finished DNA sequence of human chromosome 12.Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.Nature 440:346-351(2006) The structural basis for intramembrane assembly of an activating immunoreceptor complex.Call M.E., Wucherpfennig K.W., Chou J.J.Nat. Immunol. 11:1023-1029(2010)
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 Research Articles on KLRC2    1. genetic polymorphism is not associated with nasopharyngeal carcinoma in China
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KLRC2 recombinant proteinPathways associated with KLRC2 recombinant protein
 Reference Product  PubMed Publications
 KLRC1 recombinant protein  >244 publications with KLRC2 and KLRC1
 KLRD1 recombinant protein  >211 publications with KLRC2 and KLRD1
 HLA-E recombinant protein  >107 publications with KLRC2 and HLA-E
 NCAM1 recombinant protein  >59 publications with KLRC2 and NCAM1
 HLA-C recombinant protein  >25 publications with KLRC2 and HLA-C
 KLRC4 recombinant protein  >12 publications with KLRC2 and KLRC4
 TYROBP recombinant protein  >7 publications with KLRC2 and TYROBP
 NCR2 recombinant protein  >6 publications with KLRC2 and NCR2
 CD226 recombinant protein  >4 publications with KLRC2 and CD226
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Diseases associated with KLRC2 recombinant proteinOrgans/Tissues associated with KLRC2 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >24 publications with KLRC2 and Inflammation
 Liver Diseases Antibodies  >23 publications with KLRC2 and Liver Diseases
 Necrosis Antibodies  >19 publications with KLRC2 and Necrosis
 Carcinoma Antibodies  >12 publications with KLRC2 and Carcinoma
 Cardiovascular Diseases Antibodies  >9 publications with KLRC2 and Cardiovascular Diseases
 Demyelinating Diseases Antibodies  >9 publications with KLRC2 and Demyelinating Diseases
 Disease Models, Animal Antibodies  >8 publications with KLRC2 and Disease Models, Animal
 Adenocarcinoma Antibodies  >4 publications with KLRC2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >4 publications with KLRC2 and Liver Neoplasms
 Lung Neoplasms Antibodies  >3 publications with KLRC2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >406 publications with KLRC2 and Blood
 Liver Antibodies  >21 publications with KLRC2 and Liver
 Brain Antibodies  >4 publications with KLRC2 and Brain
 Cervix Antibodies  >1 publications with KLRC2 and Cervix
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