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NMNAT1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203614
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NMNAT1, Recombinant Protein

 Also Known As   

NMNAT1, 1-279aa, Human, His tag, E Coli

 Product Synonym Names    Nicotinamide nucleotide adenylyltransferase 1; NMNAT; PNAT1; Nicotinamide nucleotide adenylyltransferase 1
 Product Gene Name   

NMNAT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMENS EKTEVVLLAC GSFNPITNMH LRLFELAKDY MNGTGRYTVV KGIISPVGDA YKKKGLIPAY HRVIMAELAT KNSKWVEVDT WESLQKEWKE TLKVLRHHQE KLEASDCDHQ QNSPTLERPG RKRKWTETQD SSQKKSLEPK TKAVPKVKLL CGADLLESFA VPNLWKSEDI TQIVANYGLI CVTRAGNDAQ KFIYESDVLW KHRSNIHVVN EWIANDISST KIRRALRRGQ SIRYLVPDLV QEYIEKHNLY SSESEDRNAG VILAPLQRNT AEAKT
 OMIM    AF314163 mRNA
 3D Structure    ModBase 3D Structure for Q9HAN9
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol 0.1M NaCl, 1mM DTT, 1mM EDTA
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NMNAT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NMNAT1 recombinant protein

   NMNAT1, also known as NMNAT or PNAT1, is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD. It is widely expressed with high levels in skeletal muscle, heart, liver and kidney. This protein appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. Recombinant human NMNAT1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for NMNAT1 recombinant protein    Neuroscience
 Applications Tested/Suitable for NMNAT1 recombinant protein   

SDS-PAGE

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 SDS-Page of NMNAT1 recombinant protein    NMNAT1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for NMNAT1. It may not necessarily be applicable to this product.
 NCBI GI #    20070321
 NCBI GeneID    64802
 NCBI Accession #    NP_073624 [Other Products]
 NCBI GenBank Nucleotide #    NM_022787.3 [Other Products]
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 UniProt Primary Accession #    Q9HAN9 [Other Products]
 UniProt Secondary Accession #    Q8TAE9; Q9H247; Q9H6B6; B1AN63 [Other Products]
 UniProt Related Accession #    Q9HAN9 [Other Products]
 Molecular Weight    36.0 kDa (315aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform 1
 NCBI Official Synonym Full Names    nicotinamide nucleotide adenylyltransferase 1
 NCBI Official Symbol    NMNAT1 [Similar Products]
 NCBI Official Synonym Symbols   
LCA9; NMNAT; PNAT1
[Similar Products]
 NCBI Protein Information    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
 UniProt Protein Name    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
 UniProt Synonym Protein Names   
Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1
 UniProt Gene Name    NMNAT1 [Similar Products]
 UniProt Synonym Gene Names    NMNAT; NMN/NaMN adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1 [Similar Products]
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 NCBI Summary for NMNAT1    This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
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 UniProt Comments for NMNAT1    Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+ (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD+ and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+ (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults ().
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Product References and Citations for NMNAT1 recombinant protein

   Emanuelli M. et al. (2001) J Biol Chem. 276 (1):406-12.; Zhou T,.,et al. (2002) J Biol Chem. 277 (15):13148-54.;
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 Research Articles on NMNAT1    1. Hidden Genetic Variation in LCA9-Associated Congenital Blindness Explained by 5'UTR Mutations and Copy-Number Variations of NMNAT1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NMNAT1 recombinant proteinPathways associated with NMNAT1 recombinant protein
 Reference Product  PubMed Publications
 NAMPT recombinant protein  >4 publications with NMNAT1 and NAMPT
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 NAD De Novo Biosynthesis Pathway antibodies  NAD De Novo Biosynthesis Pathway Diagram
 NAD Salvage Pathway antibodies  NAD Salvage Pathway Diagram
Diseases associated with NMNAT1 recombinant proteinOrgans/Tissues associated with NMNAT1 recombinant protein
 Disease Name  Pubmed Publications
 Nerve Degeneration Antibodies  >36 publications with NMNAT1 and Nerve Degeneration
 Leber Congenital Amaurosis Antibodies  >23 publications with NMNAT1 and Leber Congenital Amaurosis
 Death Antibodies  >12 publications with NMNAT1 and Death
 Disease Models, Animal Antibodies  >10 publications with NMNAT1 and Disease Models, Animal
 Retinal Degeneration Antibodies  >10 publications with NMNAT1 and Retinal Degeneration
 Atrophy Antibodies  >8 publications with NMNAT1 and Atrophy
 Optic Atrophy Antibodies  >4 publications with NMNAT1 and Optic Atrophy
 Inflammation Antibodies  >2 publications with NMNAT1 and Inflammation
 Necrosis Antibodies  >2 publications with NMNAT1 and Necrosis
 Amaurosis congenita of Leber, type 9 Antibodies  >2 publications with NMNAT1 and Amaurosis congenita of Leber, type 9
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with NMNAT1 and Brain
 Eye Antibodies  >17 publications with NMNAT1 and Eye
 Lung Antibodies  >3 publications with NMNAT1 and Lung
 Kidney Antibodies  >3 publications with NMNAT1 and Kidney
 Muscle Antibodies  >3 publications with NMNAT1 and Muscle
 Blood Antibodies  >3 publications with NMNAT1 and Blood
 Embryonic Tissue Antibodies  >2 publications with NMNAT1 and Embryonic Tissue
 Heart Antibodies  >1 publications with NMNAT1 and Heart
 Intestine Antibodies  >1 publications with NMNAT1 and Intestine
 Prostate Antibodies  >1 publications with NMNAT1 and Prostate
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