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NNMT recombinant protein

Scan QR to view Datasheet Catalog #    MBS203321
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NNMT, Recombinant Protein

★Popular Item★
 Also Known As   

NNMT, 1-264aa, Human, His tag, E Coli

 Product Synonym Names    Nicotinamide N-methyltransferase; NNMT; Nicotinamide N-methyltransferase EC 2.1.1.1 Nicotinamide N methyltransferase.
 Product Gene Name   

NNMT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL
 OMIM    U08021 mRNA
 3D Structure    ModBase 3D Structure for P40261
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NNMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NNMT recombinant protein

   NNMT (Nicotinamide N-methyltransferase) belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. It is predominantly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Recombinant human NNMT protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for NNMT recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for NNMT recombinant protein   

SDS-PAGE

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 SDS-Page of NNMT recombinant protein    NNMT recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for NNMT. It may not necessarily be applicable to this product.
 NCBI GI #    5453790
 NCBI GeneID    4837
 NCBI Accession #    NP_006160 [Other Products]
 NCBI GenBank Nucleotide #    NM_006169.2 [Other Products]
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 UniProt Primary Accession #    P40261 [Other Products]
 UniProt Related Accession #    P40261 [Other Products]
 Molecular Weight    31.7 kDa (284aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    nicotinamide N-methyltransferase
 NCBI Official Synonym Full Names    nicotinamide N-methyltransferase
 NCBI Official Symbol    NNMT [Similar Products]
 NCBI Protein Information    nicotinamide N-methyltransferase
 UniProt Protein Name    Nicotinamide N-methyltransferase
 UniProt Gene Name    NNMT [Similar Products]
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 NCBI Summary for NNMT    N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NNMT    Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
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Product References and Citations for NNMT recombinant protein

   Parsons RB., et al. (2002). J Neuropathol Exp Neurol. 61 (2):111-24.; Smith ML., et al. (1998). Biochim Biophys Acta. 1442 (2-3):238-44.;
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 Research Articles on NNMT    1. High expression level of NNMT is associated with pancreatic cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NNMT recombinant proteinPathways associated with NNMT recombinant protein
 Reference Product  PubMed Publications
 STAT3 recombinant protein  >2 publications with NNMT and STAT3
 AOX1 recombinant protein  >2 publications with NNMT and AOX1
 CD38 recombinant protein  >1 publications with NNMT and CD38
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway antibodies  Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
 Methylation Pathway antibodies  Methylation Pathway Diagram
 Methylation Pathways antibodies  Methylation Pathways Diagram
Diseases associated with NNMT recombinant proteinOrgans/Tissues associated with NNMT recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >14 publications with NNMT and Liver Diseases
 Kidney Diseases Antibodies  >10 publications with NNMT and Kidney Diseases
 Liver Neoplasms Antibodies  >9 publications with NNMT and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >9 publications with NNMT and Cardiovascular Diseases
 Inflammation Antibodies  >9 publications with NNMT and Inflammation
 Lung Diseases Antibodies  >8 publications with NNMT and Lung Diseases
 Neoplasms, Experimental Antibodies  >7 publications with NNMT and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >7 publications with NNMT and Lung Neoplasms
 Breast Neoplasms Antibodies  >6 publications with NNMT and Breast Neoplasms
 Fatty Liver Antibodies  >5 publications with NNMT and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >49 publications with NNMT and Liver
 Brain Antibodies  >21 publications with NNMT and Brain
 Kidney Antibodies  >16 publications with NNMT and Kidney
 Lung Antibodies  >11 publications with NNMT and Lung
 Adipose Tissue Antibodies  >9 publications with NNMT and Adipose Tissue
 Heart Antibodies  >8 publications with NNMT and Heart
 Muscle Antibodies  >8 publications with NNMT and Muscle
 Mouth Antibodies  >7 publications with NNMT and Mouth
 Connective Tissue Antibodies  >7 publications with NNMT and Connective Tissue
 Uterus Antibodies  >4 publications with NNMT and Uterus
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