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NOGGIN recombinant protein

Scan QR to view Datasheet Catalog #    MBS691958 NOGGIN recombinant protein
Unit / Price
0.005 mg  /  $215 +1 FREE 8GB USB
0.02 mg  /  $360 +1 FREE 8GB USB
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 Product Name   

NOGGIN, Recombinant Protein

 Also Known As   


 Product Synonym Names    Recombinant Human NOGGIN
 Product Gene Name   

NOGGIN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.11 (56593699..56595590). Location: 17q22
 OMIM    184460
 3D Structure    ModBase 3D Structure for Q13253
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 Host    HEK 293 Cells
 Species Reactivity    Human
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 Purity/Purification    > 95% by SDS-PAGE and HPLC analysis
 Form/Format    Lyophilized
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 Endotoxin Level    < 0.1 ng per ug of NOGGIN
 Biological Activity    Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
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 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of NOGGIN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NOGGIN recombinant protein

   Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46.2 kDa non-disulfide-linked homodimer consisting of a total of 206 amino acid residues.
 Product Categories/Family for NOGGIN recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for NOGGIN. It may not necessarily be applicable to this product.
 NCBI GI #    4885523
 NCBI GeneID    9241
 NCBI Accession #    NP_005441.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005450.4 [Other Products]
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 UniProt Primary Accession #    Q13253 [Other Products]
 UniProt Related Accession #    Q13253 [Other Products]
 Molecular Weight    23.1 kDa
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 NCBI Official Full Name    noggin
 NCBI Official Synonym Full Names    noggin
 NCBI Official Symbol    NOG [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    noggin; symphalangism 1 (proximal)
 UniProt Protein Name    Noggin
 Protein Family    Noggin
 UniProt Gene Name    NOG [Similar Products]
 UniProt Entry Name    NOGG_HUMAN
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 NCBI Summary for NOGGIN    The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NOGGIN    Function: Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Ref.3

Subunit structure: Homodimer. Ref.3

Subcellular location: Secreted.

Involvement in disease: Symphalangism, proximal 1A (SYM1A) [MIM:185800]: A disease characterized by the hereditary absence of the proximal interphalangeal joints. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conductive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.5 Ref.8 Ref.9Multiple synostoses syndrome 1 (SYNS1) [MIM:186500]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.11Tarsal-carpal coalition syndrome (TCC) [MIM:186570]: Autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6Stapes ankylosis with broad thumb and toes (SABTS) [MIM:184460]: Congenital autosomal dominant disorder that includes hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7Brachydactyly B2 (BDB2) [MIM:611377]: A form of brachydactyly characterized by hypoplasia/aplasia of distal phalanges in combination with distal symphalangism, fusion of carpal/tarsal bones and partial cutaneous syndactyly.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Sequence similarities: Belongs to the noggin family.
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 Research Articles on NOGGIN    1. Even though gremlin 1 and noggin were not widely expressed in adult tissues, in a subset of organs their expression pattern indicated a potential role in normal tissue homeostasis as well as in malignancies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NOGGIN recombinant proteinPathways associated with NOGGIN recombinant protein
 Reference Product  PubMed Publications
 BMP4 recombinant protein  >18 publications with NOGGIN and BMP4
 GDF5 recombinant protein  >11 publications with NOGGIN and GDF5
 BMP2 recombinant protein  >9 publications with NOGGIN and BMP2
 BMPR1A recombinant protein  >8 publications with NOGGIN and BMPR1A
 BMPR1B recombinant protein  >4 publications with NOGGIN and BMPR1B
 BMPR2 recombinant protein  >3 publications with NOGGIN and BMPR2
 BMP7 recombinant protein  >3 publications with NOGGIN and BMP7
 BMP6 recombinant protein  >2 publications with NOGGIN and BMP6
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with NOGGIN recombinant proteinOrgans/Tissues associated with NOGGIN recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >71 publications with NOGGIN and Neoplasms
 Disease Models, Animal Antibodies  >53 publications with NOGGIN and Disease Models, Animal
 Nervous System Diseases Antibodies  >33 publications with NOGGIN and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >23 publications with NOGGIN and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >12 publications with NOGGIN and Neoplasm Metastasis
 Inflammation Antibodies  >11 publications with NOGGIN and Inflammation
 Liver Diseases Antibodies  >11 publications with NOGGIN and Liver Diseases
 Liver Neoplasms Antibodies  >10 publications with NOGGIN and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >9 publications with NOGGIN and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >8 publications with NOGGIN and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >110 publications with NOGGIN and Blood
 Spleen Antibodies  >22 publications with NOGGIN and Spleen
 Brain Antibodies  >15 publications with NOGGIN and Brain
 Uterus Antibodies  >8 publications with NOGGIN and Uterus
 Prostate Antibodies  >3 publications with NOGGIN and Prostate
 Placenta Antibodies  >1 publications with NOGGIN and Placenta
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