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NPM1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204570
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NPM1, Recombinant Protein

★Popular Item★
 Also Known As   

NPM1, 1-294aa, Human, His tag, E Coli

 Product Synonym Names    Nucleophosmin; B23; NPM
 Product Gene Name   

NPM1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS204570 MSDS    MSDS PDF
 Sequence    MGSSHHHHHH SSGLVPRGSH MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL
 OMIM    M23613 mRNA
 3D Structure    ModBase 3D Structure for P06748
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 Host    E Coli
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 Purity/Purification    > 85% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.15M NaCl, 1mM DTT
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NPM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NPM1 recombinant protein

   NPM1 is a phosphoprotein which moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in NPM1 are associated with acute myeloid leukemia. Recombinant human NPM1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for NPM1 recombinant protein    Epigenomics
 Applications Tested/Suitable for NPM1 recombinant protein   

SDS-PAGE

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 SDS-Page of NPM1 recombinant protein    NPM1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for NPM1. It may not necessarily be applicable to this product.
 NCBI GI #    10835063
 NCBI GeneID    4869
 NCBI Accession #    NP_002511 [Other Products]
 NCBI GenBank Nucleotide #    NM_002520.6 [Other Products]
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 UniProt Primary Accession #    P06748 [Other Products]
 UniProt Secondary Accession #    P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; A8K3N7; B5BU00; D3DQL6 [Other Products]
 UniProt Related Accession #    P06748 [Other Products]
 Molecular Weight    34.7kDa (314aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    nucleophosmin isoform 1
 NCBI Official Synonym Full Names    nucleophosmin 1
 NCBI Official Symbol    NPM1 [Similar Products]
 NCBI Official Synonym Symbols   
B23; NPM
[Similar Products]
 NCBI Protein Information    nucleophosmin
 UniProt Protein Name    Nucleophosmin
 UniProt Synonym Protein Names   
Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
 Protein Family    Nucleophosmin
 UniProt Gene Name    NPM1 [Similar Products]
 UniProt Synonym Gene Names    NPM; NPM [Similar Products]
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 NCBI Summary for NPM1    The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
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 UniProt Comments for NPM1    Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
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Product References and Citations for NPM1 recombinant protein

   Sagawa,F., et al. (2011) EMBO J. 30 (19), 3994-4005.; Neubauer,A., et al. (2011) Exp. Hematol. 39 (10), 1030-1042.
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 Research Articles on NPM1    1. Studies indicate that nucleophosmin 1 (NPM1) has been considered as a promising target for the treatment of both haematologic and solid malignancies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NPM1 recombinant proteinPathways associated with NPM1 recombinant protein
 Reference Product  PubMed Publications
 TP53 recombinant protein  >58 publications with NPM1 and TP53
 MYC recombinant protein  >30 publications with NPM1 and MYC
 NCL recombinant protein  >10 publications with NPM1 and NCL
 AURKB recombinant protein  >2 publications with NPM1 and AURKB
 H2AFX recombinant protein  >1 publications with NPM1 and H2AFX
 NSUN2 recombinant protein  >1 publications with NPM1 and NSUN2
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
Diseases associated with NPM1 recombinant proteinOrgans/Tissues associated with NPM1 recombinant protein
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >953 publications with NPM1 and Leukemia, Myeloid, Acute
 Chromosome Aberrations Antibodies  >126 publications with NPM1 and Chromosome Aberrations
 Leukemia, Promyelocytic, Acute Antibodies  >51 publications with NPM1 and Leukemia, Promyelocytic, Acute
 Cell Transformation, Neoplastic Antibodies  >41 publications with NPM1 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >38 publications with NPM1 and Carcinoma
 Adenocarcinoma Antibodies  >22 publications with NPM1 and Adenocarcinoma
 Anemia Antibodies  >19 publications with NPM1 and Anemia
 Breast Neoplasms Antibodies  >12 publications with NPM1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >8 publications with NPM1 and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >8 publications with NPM1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >349 publications with NPM1 and Blood
 Bone Antibodies  >236 publications with NPM1 and Bone
 Bone Marrow Antibodies  >233 publications with NPM1 and Bone Marrow
 Brain Antibodies  >18 publications with NPM1 and Brain
 Lung Antibodies  >17 publications with NPM1 and Lung
 Skin Antibodies  >11 publications with NPM1 and Skin
 Liver Antibodies  >10 publications with NPM1 and Liver
 Heart Antibodies  >8 publications with NPM1 and Heart
 Prostate Antibodies  >7 publications with NPM1 and Prostate
 Kidney Antibodies  >6 publications with NPM1 and Kidney
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