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NRK1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204376
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NRK1, Recombinant Protein

★Popular Item★
 Also Known As   

nicotinamide riboside kinase 1 isoform 1; Human, His-tagged, Recombinant, E.coli

 Product Synonym Names    bA235O14.2; NRK1; RP11-235O14.2
 Product Gene Name   

NRK1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSMKTFIIG ISGVTNSGKT TLAKNLQKHL PNCSVISQDD FFKPESEIET DKNGFLQYDV LEALNMEKMM SAISCWMESA RHSVVSTDQE SAEEIPILII EGFLLFNYKP LDTIWNRSYF LTIPYEECKR RRSTRVYQPP DSPGYFDGHV WPMYLKYRQE MQDITWEVVY LDGTKSEEDL FLQVYEDLIQ ELAKQKCLQV TA
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 Host    E.coli
 Species Reactivity    Human
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer, pH8.0, 10% glycerol, 2mM DTT, 200mM NaCl
 Concentration    0.5mg/ml (determined by Bradford assay) (lot specific)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NRK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NRK1 recombinant protein

   NRK1 belongs to the uridine kinase family. NAD+ is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADPribosyl groups used in various reactions, including those that retard aging in experimental systems. Nicotinic acid and nicotinamide were defined as the vitamin precursors of NAD+. This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine. Recombinant human NRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for NRK1 recombinant protein    Signal Transduction
 Applications Tested/Suitable for NRK1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of NRK1 recombinant protein    NRK1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for NRK1. It may not necessarily be applicable to this product.
 NCBI GI #    8923530
 NCBI GeneID    54981
 NCBI Accession #    NP_060351 [Other Products]
 NCBI GenBank Nucleotide #    NM_017881.2 [Other Products]
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 UniProt Secondary Accession #    Q5W124; Q8N430 [Other Products]
 UniProt Related Accession #    Q9NWW6 [Other Products]
 Molecular Weight    25.6kDa (222aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    nicotinamide riboside kinase 1 isoform 1
 NCBI Official Synonym Full Names    nicotinamide riboside kinase 1
 NCBI Official Symbol    NMRK1 [Similar Products]
 NCBI Official Synonym Symbols   
NRK1; C9orf95; bA235O14.2
[Similar Products]
 NCBI Protein Information    nicotinamide riboside kinase 1; NRK 1; RNK 1; nicotinic acid riboside kinase 1; nmR-K 1; ribosylnicotinamide kinase 1; ribosylnicotinic acid kinase 1
 UniProt Protein Name    Nicotinamide riboside kinase 1
 UniProt Synonym Protein Names   
Nicotinic acid riboside kinase 1 (EC:2.7.1.173); Ribosylnicotinamide kinase 1; RNK 1; Ribosylnicotinic acid kinase 1
 Protein Family    Nicotinamide riboside kinase
 UniProt Gene Name    NMRK1 [Similar Products]
 UniProt Synonym Gene Names    C9orf95; NRK1; NRK 1; NmR-K 1; RNK 1 [Similar Products]
 UniProt Entry Name    NRK1_HUMAN
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 NCBI Summary for NRK1    Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for NRK1    NRK1: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3- deazaguanosine. Belongs to the uridine kinase family. NRK subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Kinase, other; EC 2.7.1.173; EC 2.7.1.22

Chromosomal Location of Human Ortholog: 9q21.13

Molecular Function: ribosylnicotinamide kinase activity; metal ion binding; ATP binding

Biological Process: NAD biosynthetic process; phosphorylation
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Product References and Citations for NRK1 recombinant protein

   Bieganowski P, et al.(2004) Cell. 14;117(4):495-502.
Khan JA, et al. (2007) Structure. 15(8):1005-13.
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 Research Articles on NRK1    1. Crystal structure of NRK1 is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NRK1 recombinant proteinDiseases associated with NRK1 recombinant protein
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >1 publications with NRK1 and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >1 publications with NRK1 and Disease Models, Animal
Organs/Tissues associated with NRK1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with NRK1 and Nerve
 Muscle Antibodies  >1 publications with NRK1 and Muscle
 Brain Antibodies  >1 publications with NRK1 and Brain
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