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NT3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538197 NT3 recombinant protein
Unit / Price
0.002 mg  /  $180 +1 FREE 8GB USB
0.01 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NT3, Recombinant Protein

 Also Known As   

NT3 protein

 Product Synonym Names    NGF-2 protein; HGNF protein; NT-3 protein; Neurotrophic factor protein; NT 3; Neurotrophin-3 protein; NT 3 protein; Nerve growth factor-2 protein; NT3; NT-3
 Product Gene Name   

NT3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of NT3 protein correspond ing to amino acids MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT .
 OMIM    162660
 3D Structure    ModBase 3D Structure for P20783
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Allow to set for at least 30 minutes, mix well.
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 Protein Type    Recombinant
 Biological Significance    NT-3 is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, Mouse and rat NT-3 are identical.
 Bioactivity    The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of NT3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NT3 recombinant protein

   Purified recombinant Human NT3 protein
 Product Categories/Family for NT3 recombinant protein    Neuroscience
 Applications Tested/Suitable for NT3 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for NT3. It may not necessarily be applicable to this product.
 NCBI GI #    4505469
 NCBI GeneID    4908
 NCBI Accession #    NP_002518.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002527.4 [Other Products]
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 UniProt Primary Accession #    P20783 [Other Products]
 UniProt Secondary Accession #    Q6FH50; B7Z1T5 [Other Products]
 UniProt Related Accession #    P20783 [Other Products]
 Molecular Weight    13.6 kDa
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 NCBI Official Full Name    neurotrophin-3 isoform 2 preproprotein
 NCBI Official Synonym Full Names    neurotrophin 3
 NCBI Official Symbol    NTF3 [Similar Products]
 NCBI Official Synonym Symbols   
NT3; HDNF; NGF2; NT-3; NGF-2
[Similar Products]
 NCBI Protein Information    neurotrophin-3
 UniProt Protein Name    Neurotrophin-3
 UniProt Synonym Protein Names   
HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
 UniProt Gene Name    NTF3 [Similar Products]
 UniProt Synonym Gene Names    NT-3; NGF-2 [Similar Products]
 UniProt Entry Name    NTF3_HUMAN
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 NCBI Summary for NT3    The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NT3    NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; chemoattractant activity; receptor binding

Biological Process: myelination; axon guidance; epidermis development; mechanoreceptor differentiation; glial cell fate determination; activation of MAPK activity; regulation of neuron differentiation; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; cell-cell signaling; positive chemotaxis; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; nervous system development; negative regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; nerve development; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; positive regulation of cell migration
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 Research Articles on NT3    1. No differences in plasma BDNF, NGF, NT3, NT4 and GDNF were found between autism spectrum disorders and control.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NT3 recombinant proteinPathways associated with NT3 recombinant protein
 Reference Product  PubMed Publications
 BDNF recombinant protein  >22 publications with NT3 and BDNF
 NTRK3 recombinant protein  >5 publications with NT3 and NTRK3
 NGFR recombinant protein  >3 publications with NT3 and NGFR
 NTRK1 recombinant protein  >3 publications with NT3 and NTRK1
 NTRK2 recombinant protein  >3 publications with NT3 and NTRK2
 CREB1 recombinant protein  >1 publications with NT3 and CREB1
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Trk Receptor Signaling Mediated By The MAPK Pathway antibodies  Trk Receptor Signaling Mediated By The MAPK Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram
Diseases associated with NT3 recombinant proteinOrgans/Tissues associated with NT3 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with NT3 and Nervous System Diseases
 Hearing Loss Antibodies  >4 publications with NT3 and Hearing Loss
 Schizophrenia Antibodies  >2 publications with NT3 and Schizophrenia
 Neoplasm Metastasis Antibodies  >1 publications with NT3 and Neoplasm Metastasis
 Hypertension Antibodies  >1 publications with NT3 and Hypertension
 Disease Models, Animal Antibodies  >1 publications with NT3 and Disease Models, Animal
 Memory Disorders Antibodies  >1 publications with NT3 and Memory Disorders
 Learning Disorders Antibodies  >1 publications with NT3 and Learning Disorders
 Inflammation Antibodies  >1 publications with NT3 and Inflammation
 Cognition Disorders Antibodies  >1 publications with NT3 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with NT3 and Brain
 Testis Antibodies  >3 publications with NT3 and Testis
 Embryonic Tissue Antibodies  >3 publications with NT3 and Embryonic Tissue
 Eye Antibodies  >2 publications with NT3 and Eye
 Ovary Antibodies  >1 publications with NT3 and Ovary
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