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NTRK2 recombinant protein :: NTRK2/TRKB Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS844587
Testing Data
Unit / Price
0.01 mg  /  $230 +1 FREE 8GB USB
0.05 mg  /  $655 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NTRK2/TRKB, Recombinant Protein

★Popular Item★
 Also Known As   

Human CellExp NTRK2 / TRKB, human recombinant

 Product Synonym Names    NTRK2; TRKB; GP145-TrkB.
 Product Gene Name   

NTRK2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600456
 3D Structure    ModBase 3D Structure for Q16620
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 Host    HEK293 cells (Cys 32-His 430)
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 Purity/Purification    >=95% by SDS-PAGE gel
 Form/Format    Lyophilized from 0.22 mum filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Appearance: Lyophilized
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 Solubility/Reconstitution Instructions    Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
 Endotoxin Level    <1 EU/mug by LAL method
 Biological Activity    Measured by its ability to bind mouse BDNF in functional ELISA.
 Handling    Centrifuge the vial prior to opening.
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 Preparation and Storage    At -20 degree C
After reconstitution, aliquot and store at -20 degree C and use within 3 months. Avoid reapeated freezeing and thawing cycles.
Shelf Life: 12 months
 Other Notes    Small volumes of NTRK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NTRK2 recombinant protein

   Background: Neurotrophic tyrosine kinase receptor type 2 (NTRK2) also known as BDNF/NT-3 growth factors receptor, Tropomyosin-related kinase B (TRKB) and TrkB tyrosine kinase, which belongs to the protein kinase superfamily or Tyr protein kinase family. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate". NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.
 Product Categories/Family for NTRK2 recombinant protein    Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Proteins and Enzymes (A-Z)Proteins and Enzymes; Other Proteins & Enzymes
 Applications Tested/Suitable for NTRK2 recombinant protein   


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 Testing Data of NTRK2 recombinant protein    NTRK2 recombinant protein Testing Data image
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NCBI/Uniprot data below describe general gene information for NTRK2. It may not necessarily be applicable to this product.
 NCBI GI #    55956790
 NCBI GeneID    4915
 NCBI Accession #    NP_001007098.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001007097.2 [Other Products]
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 UniProt Primary Accession #    Q16620 [Other Products]
 UniProt Secondary Accession #    Q16675; Q59GJ1; Q8WXJ5; Q8WXJ6; Q8WXJ7; B1ANZ4; B4DFV9 [Other Products]
 UniProt Related Accession #    Q16620 [Other Products]
 Molecular Weight    This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 45 kDa. The predicted N-terminus is Cys 32. DTT-reduced Protein migrates as 60-90 kDa due to glycosylation.
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 NCBI Official Full Name    BDNF/NT-3 growth factors receptor isoform b
 NCBI Official Synonym Full Names    neurotrophic tyrosine kinase, receptor, type 2
 NCBI Official Symbol    NTRK2 [Similar Products]
 NCBI Official Synonym Symbols   
TRKB; trk-B; GP145-TrkB
[Similar Products]
 NCBI Protein Information    BDNF/NT-3 growth factors receptor
 UniProt Protein Name    BDNF/NT-3 growth factors receptor
 UniProt Synonym Protein Names   
GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
 Protein Family    BDNF/NT-3 growth factors receptor
 UniProt Gene Name    NTRK2 [Similar Products]
 UniProt Synonym Gene Names    TRKB; Trk-B [Similar Products]
 UniProt Entry Name    NTRK2_HUMAN
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 NCBI Summary for NTRK2    This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for NTRK2    TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC; Kinase, protein; TK group; Trk family

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: postsynaptic membrane; cell surface; growth cone; rough endoplasmic reticulum; integral to plasma membrane; presynaptic active zone; dendritic spine; terminal button; excitatory synapse; perikaryon; endosome membrane; cytosol; receptor complex

Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; ATP binding

Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of neurotransmitter secretion; neuron migration; regulation of dendrite development; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; vasculogenesis; inflammatory response; neuromuscular junction development; aging; central nervous system neuron development; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system neuron development; positive regulation of phosphoinositide 3-kinase cascade; glutamate secretion; long-term memory; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Obesity, Hyperphagia, And Developmental Delay
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 Research Articles on NTRK2    1. Site-specific differential methylation in the TrkB-T1 3'UTR region associates with functional changes in TrkB-T1 expression and may play a significant role in the important decrease of cortical TrkB-T1 expression observed among suicide completers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NTRK2 recombinant proteinDiseases associated with NTRK2 recombinant protein
 Reference Product  PubMed Publications
 BDNF recombinant protein  >93 publications with NTRK2 and BDNF
 NGFR recombinant protein  >11 publications with NTRK2 and NGFR
 NTF3 recombinant protein  >3 publications with NTRK2 and NTF3
 NTF4 recombinant protein  >3 publications with NTRK2 and NTF4
 SH2B1 recombinant protein  >1 publications with NTRK2 and SH2B1
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with NTRK2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >15 publications with NTRK2 and Disease Models, Animal
 Depressive Disorder Antibodies  >13 publications with NTRK2 and Depressive Disorder
 Neuroblastoma Antibodies  >10 publications with NTRK2 and Neuroblastoma
 Obesity Antibodies  >9 publications with NTRK2 and Obesity
 Glioma Antibodies  >8 publications with NTRK2 and Glioma
 Bipolar Disorder Antibodies  >8 publications with NTRK2 and Bipolar Disorder
 Lung Neoplasms Antibodies  >6 publications with NTRK2 and Lung Neoplasms
 Anxiety Disorders Antibodies  >6 publications with NTRK2 and Anxiety Disorders
 Hyperphagia Antibodies  >5 publications with NTRK2 and Hyperphagia
Organs/Tissues associated with NTRK2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >118 publications with NTRK2 and Brain
 Nerve Antibodies  >47 publications with NTRK2 and Nerve
 Lung Antibodies  >11 publications with NTRK2 and Lung
 Ovary Antibodies  >7 publications with NTRK2 and Ovary
 Kidney Antibodies  >5 publications with NTRK2 and Kidney
 Heart Antibodies  >4 publications with NTRK2 and Heart
 Thyroid Antibodies  >4 publications with NTRK2 and Thyroid
 Embryonic Tissue Antibodies  >4 publications with NTRK2 and Embryonic Tissue
 Bone Antibodies  >4 publications with NTRK2 and Bone
 Eye Antibodies  >3 publications with NTRK2 and Eye
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