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NEDD8 recombinant protein :: Neural Precursor Cell Expressed Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143595 NEDD8 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neural Precursor Cell Expressed (NEDD8), Recombinant Protein

 Also Known As   

Recombinant Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 8

 Product Synonym Names    NEDD8 Human; Neural Precursor Cell Expressed Developmentally Down-Regulated 8 Human Recombinant; Nedd-8; FLJ43224; MGC104393; MGC125896; MGC125897; NEDD8; Ubiquitin-like protein Nedd8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8
 Product Gene Name   

NEDD8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MHHHHHH MKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET AMTINGPWAW SNIDTSKVNY GVTVLPTFKG QPSKPFVGVL SAGINAASPN KELAKEFLEN YLLTDEGLEA VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGI LCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLHAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYV HALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR
 OMIM    603171
 3D Structure    ModBase 3D Structure for Q15843
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The NEDD8 solution contains 20mM Tris pH 8.0, 50mM NaCl, 0.5mM DTT & 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    NEDD8 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of NEDD8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NEDD8 recombinant protein

   Description: NEDD8 Human Recombinant fused with 37 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 113 amino acids (1-76 a.a.) and having a molecular mass of 12.8 kDa.The NEDD8 is purified by proprietary chromatographic techniques.

Introduction: NEDD8 is part of the ubiquitin family. Human NEDD8 shares 60% amino acid sequence homology to ubiquitin. The NEDD8 system is essential for the regulation of protein degradation pathways involved in cell cycle progression, morphogenesis and tumorigenesis. NEDD8 is involved in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E-1 complex UbE1c- appbp1 and linkage to the E-2 enzyme UbE2m. Attachment of NEDD8 to cullins activates their associated E-3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
 Product Categories/Family for NEDD8 recombinant protein    ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme
NCBI/Uniprot data below describe general gene information for NEDD8. It may not necessarily be applicable to this product.
 NCBI GI #    5453760
 NCBI GeneID    4738
 NCBI Accession #    NP_006147.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006156.2 [Other Products]
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 UniProt Primary Accession #    Q15843 [Other Products]
 UniProt Secondary Accession #    Q3SXN8; Q6LES6 [Other Products]
 UniProt Related Accession #    Q15843 [Other Products]
 Molecular Weight    9,072 Da
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 NCBI Official Full Name    NEDD8
 NCBI Official Synonym Full Names    neural precursor cell expressed, developmentally down-regulated 8
 NCBI Official Symbol    NEDD8 [Similar Products]
 NCBI Official Synonym Symbols   
NEDD-8
[Similar Products]
 NCBI Protein Information    NEDD8; neddylin; ubiquitin-like protein Nedd8
 UniProt Protein Name    NEDD8
 UniProt Synonym Protein Names   
Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8
 Protein Family    NEDD8
 UniProt Gene Name    NEDD8 [Similar Products]
 UniProt Synonym Gene Names    NEDD-8 [Similar Products]
 UniProt Entry Name    NEDD8_HUMAN
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 UniProt Comments for NEDD8    NEDD8: a member of the ubiquitin family of proteins. Approximately 60% identical to ubiquitin protein. Activated by an E1-like complex, consisting of App-b1 and Uba3 and then linked to the E2-like enzyme, Ubc12. The major target protein modified by nedd8 is cullin-4a. Down-regulated during the development of brain.

Protein type: Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: cytosol; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; protein neddylation; protein localization; anatomical structure morphogenesis; transforming growth factor beta receptor signaling pathway; protein modification process; proteolysis; response to organic cyclic substance
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 Research Articles on NEDD8    1. SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NEDD8 recombinant proteinPathways associated with NEDD8 recombinant protein
 Reference Product  PubMed Publications
 CUL1 recombinant protein  >62 publications with NEDD8 and CUL1
 UBA3 recombinant protein  >44 publications with NEDD8 and UBA3
 NUB1 recombinant protein  >26 publications with NEDD8 and NUB1
 CUL3 recombinant protein  >22 publications with NEDD8 and CUL3
 CUL2 recombinant protein  >21 publications with NEDD8 and CUL2
 SENP8 recombinant protein  >19 publications with NEDD8 and SENP8
 CUL5 recombinant protein  >12 publications with NEDD8 and CUL5
 TP53 recombinant protein  >7 publications with NEDD8 and TP53
 UBE2M recombinant protein  >4 publications with NEDD8 and UBE2M
 UBC recombinant protein  >1 publications with NEDD8 and UBC
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
 SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway antibodies  SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway Diagram
 SMAD4 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD4 MH2 Domain Mutants In Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
Diseases associated with NEDD8 recombinant proteinOrgans/Tissues associated with NEDD8 recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >11 publications with NEDD8 and Adenocarcinoma
 Inflammation Antibodies  >10 publications with NEDD8 and Inflammation
 Necrosis Antibodies  >10 publications with NEDD8 and Necrosis
 Kidney Diseases Antibodies  >7 publications with NEDD8 and Kidney Diseases
 Liver Diseases Antibodies  >5 publications with NEDD8 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with NEDD8 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >4 publications with NEDD8 and Liver Neoplasms
 Breast Neoplasms Antibodies  >4 publications with NEDD8 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >4 publications with NEDD8 and Ovarian Neoplasms
 Prostatic Diseases Antibodies  >3 publications with NEDD8 and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with NEDD8 and Brain
 Blood Antibodies  >23 publications with NEDD8 and Blood
 Kidney Antibodies  >15 publications with NEDD8 and Kidney
 Vascular Antibodies  >13 publications with NEDD8 and Vascular
 Nerve Antibodies  >12 publications with NEDD8 and Nerve
 Heart Antibodies  >9 publications with NEDD8 and Heart
 Muscle Antibodies  >9 publications with NEDD8 and Muscle
 Liver Antibodies  >9 publications with NEDD8 and Liver
 Lung Antibodies  >9 publications with NEDD8 and Lung
 Embryonic Tissue Antibodies  >8 publications with NEDD8 and Embryonic Tissue
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