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NRG1 recombinant protein :: Neuregulin 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650011 NRG1 recombinant protein
Unit / Price
0.01 mg  /  $345 +1 FREE 8GB USB
0.05 mg  /  $420 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuregulin 1 (NRG1), Recombinant Protein

★Popular Item★
 Also Known As   

Neuregulin 1, Recombinant, Human (NRG1, NDF)

 Product Gene Name   

NRG1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKAEELY Q
 Chromosome Location    Chromosome: 8; NC_000008.10 (31496820..32622558). Location: 8p12
 3D Structure    ModBase 3D Structure for Q53F54
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 Host    E Coli
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 Purity/Purification    Highly Purified
95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.
 Form/Format    Supplied as a lyophilized powder from 20mM phosphate buffer, pH 7.4, 150mM sodium chloride. Reconstitute with sterile ddH2O, to a concentration of 100ug/ml.
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 Biological Activity    The activity measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions corresponding to a specific activity of 1.2x10e4 units/mg.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of NRG1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NRG1 recombinant protein

   Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that recombinant neuregulin could make disturbed myocardial cell structure into order and strengthen the connection between myocardial cells by intercalated discs re-organization. Pharmacodynamic experiments in animals showed that recombinant neuregulin (NRG1) can reduce the degree of damage on myocardial cells caused by ischemia, hypoxia and viral infection.

Recombinant Human Neuroregulin-1 (Neu differentiation factor) produced in E. coli is a single, non-glycosylated polypeptide chain containing 61 amino acids having a molecular mass of 7055D. Recombinant Human NRG1 is purified by proprietary chromatographic techniques.
 Product Categories/Family for NRG1 recombinant protein    Growth Factors, Cytokines; Growth Factors-Other
NCBI/Uniprot data below describe general gene information for NRG1. It may not necessarily be applicable to this product.
 NCBI GI #    49522883
 NCBI GeneID    3084
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 UniProt Primary Accession #    Q53F54 [Other Products]
 UniProt Related Accession #    Q02297; Q53F54; Q6ICV5; Q6PK61; Q7RTV8; Q7RTW3; Q7RTW4; Q7RTW5; Q7Z2R7; Q86WJ0 [Other Products]
 Molecular Weight    7.1kD [Similar Products]
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 NCBI Official Full Name    Neuregulin 1
 NCBI Official Synonym Full Names    neuregulin 1
 NCBI Official Symbol    NRG1 [Similar Products]
 NCBI Official Synonym Symbols   
GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131
[Similar Products]
 NCBI Protein Information    pro-neuregulin-1, membrane-bound isoform; MSTP131; pro-NRG1; OTTHUMP00000225398; OTTHUMP00000225419; OTTHUMP00000225420; OTTHUMP00000225421; OTTHUMP00000225422; OTTHUMP00000225477; OTTHUMP00000225545; OTTHUMP00000230603; OTTHUMP00000230605; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator)
 UniProt Protein Name    Neuregulin 1 isoform SMDF variant
 Protein Family    Pro-neuregulin
 UniProt Entry Name    Q53F54_HUMAN
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 NCBI Summary for NRG1    The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq]
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 UniProt Comments for NRG1    NRG1: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. The cytoplasmic domain interacts with the LIM domain region of LIMK1. Interacts with ERBB3 and ERBB4. Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. Belongs to the neuregulin family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Cell development/differentiation; Cytokine

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: extracellular space; membrane; integral to plasma membrane; axon; apical plasma membrane; cytoplasm; extracellular region; neuromuscular junction; nucleus

Molecular Function: ErbB-2 class receptor binding; protein binding; transmembrane receptor protein tyrosine kinase activator activity; growth factor activity; ErbB-3 class receptor binding; transcription cofactor activity; cytokine activity; protein tyrosine kinase activator activity; receptor tyrosine kinase binding; receptor binding

Biological Process: regulation of protein heterodimerization activity; positive regulation of cell adhesion; transmembrane receptor protein tyrosine kinase activation (dimerization); nerve growth factor receptor signaling pathway; wound healing; cellular protein complex disassembly; neural crest cell development; cell morphogenesis; ventricular cardiac muscle cell differentiation; locomotory behavior; positive regulation of striated muscle cell differentiation; cardiac muscle cell differentiation; synaptogenesis; mammary gland development; cell communication; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; neurotransmitter receptor metabolic process; regulation of protein homodimerization activity; MAPKKK cascade; neuron fate commitment; positive regulation of cell growth; peripheral nervous system development; positive regulation of protein kinase B signaling cascade; cell proliferation; embryonic development; glial cell fate commitment; innate immune response; negative regulation of secretion; positive regulation of Ras protein signal transduction; negative regulation of protein catabolic process; negative regulation of transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Schizophrenia 6
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 Research Articles on NRG1    1. NRG1 variants are specifically underrepresented in subgroups of schizophrenic subjects with early age of onset and high positive symptom load.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NRG1 recombinant proteinPathways associated with NRG1 recombinant protein
 Reference Product  PubMed Publications
 ERBB4 recombinant protein  >140 publications with NRG1 and ERBB4
 ERBB3 recombinant protein  >65 publications with NRG1 and ERBB3
 EGF recombinant protein  >54 publications with NRG1 and EGF
 ADAM19 recombinant protein  >2 publications with NRG1 and ADAM19
 DLG4 recombinant protein  >1 publications with NRG1 and DLG4
 HPRD recombinant protein  >1 publications with NRG1 and HPRD
 Products by Pathway  Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
Diseases associated with NRG1 recombinant proteinOrgans/Tissues associated with NRG1 recombinant protein
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >316 publications with NRG1 and Schizophrenia
 Nervous System Diseases Antibodies  >81 publications with NRG1 and Nervous System Diseases
 Neoplasms Antibodies  >65 publications with NRG1 and Neoplasms
 Disease Models, Animal Antibodies  >54 publications with NRG1 and Disease Models, Animal
 Brain Diseases Antibodies  >40 publications with NRG1 and Brain Diseases
 Breast Neoplasms Antibodies  >30 publications with NRG1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >23 publications with NRG1 and Cardiovascular Diseases
 Cognition Disorders Antibodies  >17 publications with NRG1 and Cognition Disorders
 Carcinoma Antibodies  >17 publications with NRG1 and Carcinoma
 Heart Diseases Antibodies  >15 publications with NRG1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >249 publications with NRG1 and Nerve
 Brain Antibodies  >203 publications with NRG1 and Brain
 Bone Antibodies  >9 publications with NRG1 and Bone
 Kidney Antibodies  >6 publications with NRG1 and Kidney
 Eye Antibodies  >6 publications with NRG1 and Eye
 Liver Antibodies  >4 publications with NRG1 and Liver
 Skin Antibodies  >3 publications with NRG1 and Skin
 Intestine Antibodies  >2 publications with NRG1 and Intestine
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