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NRAS recombinant protein :: Neuroblastoma RAS Viral Oncogene Homolog Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143929 NRAS recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuroblastoma RAS Viral Oncogene Homolog (NRAS), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Neuroblastoma RAS Viral Oncogene Homolog

 Product Synonym Names    GTPase NRas, HRAS1, ALPS4, N-ras, NRAS1, NS6, Transforming protein N-Ras.
 Product Gene Name   

NRAS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-186
 Sequence    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPC
 OMIM    137550
 3D Structure    ModBase 3D Structure for P01111
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The NRAS protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5, 100mM NaCl, and 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Physical Appearance    Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks.
Store, frozen at -20C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
 Other Notes    Small volumes of NRAS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NRAS recombinant protein

   Description: NRAS Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 186 amino acids (1-186 a.a.) and having a molecular mass of 20.8kDa. The NRAS is purified by conventional chromatography.

Introduction: NRAS binds GDP/GTP and has intrinsic GTPase activity. NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This transport is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. NRAS is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this NRAS gene result in juvenile myelomonocytic leukemia.
 Product Categories/Family for NRAS recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for NRAS. It may not necessarily be applicable to this product.
 NCBI GI #    4505451
 NCBI GeneID    4893
 NCBI Accession #    NP_002515.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002524.4 [Other Products]
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 UniProt Primary Accession #    P01111 [Other Products]
 UniProt Secondary Accession #    Q14971; Q15104; Q15282 [Other Products]
 UniProt Related Accession #    P01111 [Other Products]
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 NCBI Official Full Name    GTPase NRas
 NCBI Official Synonym Full Names    neuroblastoma RAS viral (v-ras) oncogene homolog
 NCBI Official Symbol    NRAS [Similar Products]
 NCBI Official Synonym Symbols   
NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1
[Similar Products]
 NCBI Protein Information    GTPase NRas; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
 UniProt Protein Name    GTPase NRas
 UniProt Synonym Protein Names   
Transforming protein N-Ras
 Protein Family    GTPase
 UniProt Gene Name    NRAS [Similar Products]
 UniProt Synonym Gene Names    HRAS1 [Similar Products]
 UniProt Entry Name    RASN_HUMAN
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 NCBI Summary for NRAS    This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
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 UniProt Comments for NRAS    NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Oncoprotein; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: Golgi membrane; membrane; plasma membrane

Molecular Function: GTP binding; protein complex binding

Biological Process: regulation of long-term neuronal synaptic plasticity; epidermal growth factor receptor signaling pathway; negative regulation of skeletal muscle development; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; MAPKKK cascade; regulation of synaptic transmission, GABAergic; positive regulation of Rac protein signal transduction; negative regulation of cell differentiation; small GTPase mediated signal transduction; positive regulation of cell proliferation; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; striated muscle cell differentiation; visual learning; negative regulation of neuron apoptosis; blood coagulation; actin cytoskeleton organization and biogenesis; vascular endothelial growth factor receptor signaling pathway; leukocyte migration

Disease: Thyroid Carcinoma, Follicular; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Noonan Syndrome 6; Melanocytic Nevus Syndrome, Congenital; Colorectal Cancer; Melanosis, Neurocutaneous; Nevus, Epidermal
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 Research Articles on NRAS    1. NRAS expression is required for the proliferative advantage of human AML cell lines in vitro and for the maintenance of mouse Nras-mutant AML in vivo
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NRAS recombinant proteinPathways associated with NRAS recombinant protein
 Reference Product  PubMed Publications
 BRAF recombinant protein  >718 publications with NRAS and BRAF
 PIK3CA recombinant protein  >179 publications with NRAS and PIK3CA
 EGFR recombinant protein  >153 publications with NRAS and EGFR
 PTPN11 recombinant protein  >62 publications with NRAS and PTPN11
 ERBB2 recombinant protein  >32 publications with NRAS and ERBB2
 RAF1 recombinant protein  >30 publications with NRAS and RAF1
 ERBB3 recombinant protein  >4 publications with NRAS and ERBB3
 FOS recombinant protein  >3 publications with NRAS and FOS
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of RAS In B Cells Pathway antibodies  Activation Of RAS In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with NRAS recombinant proteinOrgans/Tissues associated with NRAS recombinant protein
 Disease Name  Pubmed Publications
 Melanoma Antibodies  >476 publications with NRAS and Melanoma
 Colorectal Neoplasms Antibodies  >95 publications with NRAS and Colorectal Neoplasms
 Cell Transformation, Neoplastic Antibodies  >66 publications with NRAS and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >58 publications with NRAS and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >56 publications with NRAS and Neoplasms, Experimental
 Lymphoma Antibodies  >54 publications with NRAS and Lymphoma
 Neuroblastoma Antibodies  >48 publications with NRAS and Neuroblastoma
 Nervous System Diseases Antibodies  >41 publications with NRAS and Nervous System Diseases
 Leukemia, Myelomonocytic, Juvenile Antibodies  >39 publications with NRAS and Leukemia, Myelomonocytic, Juvenile
 Thyroid cancer, follicular Antibodies  >32 publications with NRAS and Thyroid cancer, follicular
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >266 publications with NRAS and Skin
 Blood Antibodies  >143 publications with NRAS and Blood
 Lung Antibodies  >93 publications with NRAS and Lung
 Bone Antibodies  >76 publications with NRAS and Bone
 Bone Marrow Antibodies  >63 publications with NRAS and Bone Marrow
 Lymph Node Antibodies  >52 publications with NRAS and Lymph Node
 Lymph Antibodies  >50 publications with NRAS and Lymph
 Liver Antibodies  >42 publications with NRAS and Liver
 Brain Antibodies  >42 publications with NRAS and Brain
 Nerve Antibodies  >19 publications with NRAS and Nerve
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