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NF1 recombinant protein :: Neurofibromin (NF1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953948 NF1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,345 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,565 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,565 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,190 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,190 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,650 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,650 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurofibromin (NF1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Neurofibromin (NF1) , partial

 Product Gene Name   

NF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-551; Isoform 3 (identifier: P21359-3), full length
 Sequence    AAHRPVEWVQ AVVSRFDEQL PIKTGQQNTH TKVSTEHNKE CLINISKYKF SLVISGLTTI LKNVNNMRIF GEAAEKNLYL SQLIILDTLE KCLAGQPKDT MRLDETMLVK QLLPEICHFL HTCREGNQHA AELRNSASGV LFSLSCNNFN AVFSRISTRL QELTVCSEDN VDVHDIELLQ YINVDCAKLK RLLKETAFKF KALKKVAQLA VINSLEKAFW NWVENYPDEF TKLYQIPQTD MAECAEKLFD LVDGFAESTK RKAAVWPLQI ILLILCPEII QDISKDVVDE NNMNKKLFLD SLRKALAGHG GSRQLTESAA IACVKLCKAS TYINWEDNSV IFLLVQSMVV DLKNLLFNPS KPFSRGSQPA DVDLMIDCLV SCFRISPHNN QHFKICLAQN SPSTFHYVLV NSLHRIITNS ALDWWPKIDA VYCHSVELRN MFGETLHKAV QGCGAHPAIR MAPSLTFKEK VTSLKFKEKP TDLETRSYKY LLLSMVKLIH ADPKLLLCNP RKQGPETQGS TAELITGLVQ LVPQSHMPEI AQEAMEVRGK
 OMIM    114500
 3D Structure    ModBase 3D Structure for P21359
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NF1 recombinant protein

   This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
NCBI/Uniprot data below describe general gene information for NF1. It may not necessarily be applicable to this product.
 NCBI GI #    4557793
 NCBI GeneID    4763
 NCBI Accession #    NP_000258.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000267.3 [Other Products]
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 UniProt Primary Accession #    P21359 [Other Products]
 UniProt Secondary Accession #    O00662; Q14284; Q14930; Q14931; Q9UMK3 [Other Products]
 UniProt Related Accession #    P21359 [Other Products]
 Molecular Weight    318,992 Da
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 NCBI Official Full Name    neurofibromin isoform 2
 NCBI Official Synonym Full Names    neurofibromin 1
 NCBI Official Symbol    NF1 [Similar Products]
 NCBI Official Synonym Symbols   
WSS; NFNS; VRNF
[Similar Products]
 NCBI Protein Information    neurofibromin
 UniProt Protein Name    Neurofibromin
 UniProt Synonym Protein Names   
Neurofibromatosis-related protein NF-1
 Protein Family    Neurofibromin
 UniProt Gene Name    NF1 [Similar Products]
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 NCBI Summary for NF1    This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NF1    Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
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 Research Articles on NF1    1. this studies show the ability of miR-10b to activate the expression of c-Jun through RhoC and NF1, which represents a novel pathway for promoting migration and invasion of human cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NF1 recombinant proteinPathways associated with NF1 recombinant protein
 Reference Product  PubMed Publications
 HRAS recombinant protein  >32 publications with NF1 and HRAS
 APP recombinant protein  >6 publications with NF1 and APP
 TBPL1 recombinant protein  >2 publications with NF1 and TBPL1
 SDC2 recombinant protein  >1 publications with NF1 and SDC2
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Signaling Pathways In Glioblastoma antibodies  Signaling Pathways In Glioblastoma Diagram
 Syndecan-2-mediated Signaling Events Pathway antibodies  Syndecan-2-mediated Signaling Events Pathway Diagram
 Pilocytic Astrocytoma Pathway antibodies  Pilocytic Astrocytoma Pathway Diagram
Diseases associated with NF1 recombinant proteinOrgans/Tissues associated with NF1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2276 publications with NF1 and Neoplasms
 WATSON SYNDROME Antibodies  >1935 publications with NF1 and WATSON SYNDROME
 Nervous System Diseases Antibodies  >1933 publications with NF1 and Nervous System Diseases
 Neurofibromatosis 1 Antibodies  >1933 publications with NF1 and Neurofibromatosis 1
 Nerve Sheath Neoplasms Antibodies  >1808 publications with NF1 and Nerve Sheath Neoplasms
 Neurofibromatoses Antibodies  >1675 publications with NF1 and Neurofibromatoses
 Brain Diseases Antibodies  >258 publications with NF1 and Brain Diseases
 Astrocytoma Antibodies  >203 publications with NF1 and Astrocytoma
 Eye Diseases Antibodies  >187 publications with NF1 and Eye Diseases
 Cardiovascular Diseases Antibodies  >166 publications with NF1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >477 publications with NF1 and Brain
 Blood Antibodies  >272 publications with NF1 and Blood
 Bone Antibodies  >264 publications with NF1 and Bone
 Skin Antibodies  >224 publications with NF1 and Skin
 Vascular Antibodies  >150 publications with NF1 and Vascular
 Muscle Antibodies  >112 publications with NF1 and Muscle
 Eye Antibodies  >87 publications with NF1 and Eye
 Bone Marrow Antibodies  >64 publications with NF1 and Bone Marrow
 Spinal Cord Antibodies  >55 publications with NF1 and Spinal Cord
 Heart Antibodies  >55 publications with NF1 and Heart
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