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NFL recombinant protein :: Neurofilament light polypeptide Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS9422422 NFL recombinant protein
Unit / Price
0.01 mg  /  $230 +1 FREE 8GB USB
0.05 mg  /  $290 +1 FREE 8GB USB
0.1 mg  /  $455 +1 FREE 8GB USB
0.2 mg  /  $705 +1 FREE 8GB USB
0.5 mg  /  $1,145 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurofilament light polypeptide (NFL), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mus musculus Neurofilament light polypeptide

 Product Synonym Names    68 kDa neurofilament protein; Neurofilament triplet L protein
 Product Gene Name   

NFL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    Full Length, 2-543aa
 Sequence    SSFGYDPYFS TSYKRRYVET PRVHISSVRS GYSTARSAYS SYSAPVSSSL SVRRSYSSSS GSLMPSLENL DLSQVAAISN DLKSIRTQEK AQLQDLNDRF ASFIERVHEL EQQNKVLEAE LLVLRQKHSE PSRFRALYEQ EIRDLRLAAE DATNEKQALQ GEREGLEETL RNLQARYEEE VLSREDAEGR LMEARKGADE AALARAELEK RIDSLMDEIA FLKKVHEEEI AELQAQIQYA QISVEMDVSS KPDLSAALKD IRAQYEKLAA KNMQNAEEWF KSRFTVLTES AAKNTDAVRA AKDEVSESRR LLKAKTLEIE ACRGMNEALE KQLQELEDKQ NADISAMQDT INKLENELRS TKSEMARYLK EYQDLLNVKM ALDIEIAAYR KLLEGEETRL SFTSVGSITS GYSQSSQVFG RSAYSGLQSS SYLMSARSFP AYYTSHVQEE QTEVEETIEA TKAEEAKDEP PSEGEAEEEE KEKEEGEEEE GAEEEEAAKD ESEDTKEEEE GGEGEEEDTK ESEEEEKKEE SAGEEQVAKK KD
 3D Structure    ModBase 3D Structure for P08551
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 Host    Yeast
 Species Reactivity    Mouse
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    20mM Tris-HCl based buffer, pH8.0
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 Target Name    NFL
 Calculated MW    63.38 kD
 Target Length    Full length-2-543
 Tag Info    His-tag
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 Preparation and Storage    Store at -20C, for extended storage, conserve at -20C or -80C. Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
 Other Notes    Small volumes of NFL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NFL recombinant protein

   Recombinant protein

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
NCBI/Uniprot data below describe general gene information for NFL. It may not necessarily be applicable to this product.
 NCBI GI #    39204499
 NCBI GeneID    18039
 NCBI Accession #    NP_035040.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010910.1 [Other Products]
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 UniProt Primary Accession #    P08551 [Other Products]
 UniProt Secondary Accession #    Q8K0Z0 [Other Products]
 UniProt Related Accession #    P08551 [Other Products]
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 NCBI Official Full Name    neurofilament light polypeptide
 NCBI Official Synonym Full Names    neurofilament, light polypeptide
 NCBI Official Symbol    Nefl [Similar Products]
 NCBI Official Synonym Symbols   
Nfl; NF-L; NF68; CMT2E; AI847934
[Similar Products]
 NCBI Protein Information    neurofilament light polypeptide
 UniProt Protein Name    Neurofilament light polypeptide
 UniProt Synonym Protein Names   
68 kDa neurofilament protein; Neurofilament triplet L protein
 Protein Family    Neurofilament light polypeptide
 UniProt Gene Name    Nefl [Similar Products]
 UniProt Synonym Gene Names    Nf68; Nfl; NF-L [Similar Products]
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 UniProt Comments for NFL    NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F).

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 14|14 D1

Cellular Component: axon; cytoplasm; growth cone; intermediate filament; myelin sheath; neurofilament; neuron projection; TSC1-TSC2 complex

Molecular Function: identical protein binding; phospholipase binding; protein binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; structural constituent of cytoskeleton

Biological Process: anterograde axon cargo transport; axon regeneration in the peripheral nervous system; axon transport of mitochondrion; intermediate filament bundle assembly; intermediate filament organization; intermediate filament polymerization and/or depolymerization; locomotion; microtubule cytoskeleton organization and biogenesis; negative regulation of neuron apoptosis; neurite morphogenesis; neurofilament bundle assembly; neurofilament cytoskeleton organization and biogenesis; neuromuscular process controlling balance; positive regulation of axonogenesis; protein polymerization; regulation of axon diameter; retrograde axon cargo transport
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 Research Articles on NFL    1. It may have a role in protecting neurites from dystrophy and in regulating cellular pathways related to the generation of Ab plaques.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NFL recombinant proteinPathways associated with NFL recombinant protein
 Reference Product  PubMed Publications
 Nefh recombinant protein  >7 publications with NFL and Nefh
 Nefm recombinant protein  >4 publications with NFL and Nefm
 Ina recombinant protein  >2 publications with NFL and Ina
 Tsc1 recombinant protein  >1 publications with NFL and Tsc1
 Prph recombinant protein  >1 publications with NFL and Prph
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with NFL recombinant proteinOrgans/Tissues associated with NFL recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >73 publications with NFL and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >58 publications with NFL and Peripheral Nervous System Diseases
 Brain Diseases Antibodies  >12 publications with NFL and Brain Diseases
 Atrophy Antibodies  >12 publications with NFL and Atrophy
 Breast Neoplasms Antibodies  >9 publications with NFL and Breast Neoplasms
 Disease Models, Animal Antibodies  >6 publications with NFL and Disease Models, Animal
 Charcot-Marie-Tooth disease, Type 2E Antibodies  >4 publications with NFL and Charcot-Marie-Tooth disease, Type 2E
 Ataxia Antibodies  >3 publications with NFL and Ataxia
 Lung Neoplasms Antibodies  >3 publications with NFL and Lung Neoplasms
 Hypertension Antibodies  >2 publications with NFL and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >33 publications with NFL and Brain
 Muscle Antibodies  >19 publications with NFL and Muscle
 Prostate Antibodies  >11 publications with NFL and Prostate
 Spinal Cord Antibodies  >9 publications with NFL and Spinal Cord
 Eye Antibodies  >4 publications with NFL and Eye
 Dorsal Root Ganglion Antibodies  >2 publications with NFL and Dorsal Root Ganglion
 Embryonic Tissue Antibodies  >2 publications with NFL and Embryonic Tissue
 Pancreas Antibodies  >1 publications with NFL and Pancreas
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