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Nefm recombinant protein :: Neurofilament medium polypeptide (Nefm), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952483 Nefm recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,210 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,210 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,445 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,445 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,905 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,905 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,940 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,850 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurofilament medium polypeptide (Nefm), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse Neurofilament medium polypeptide (Nefm), partial

 Product Synonym Names    Neurofilament medium polypeptide; NF-M; 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein
 Product Gene Name   

Nefm recombinant protein

[Similar Products]
 Product Synonym Gene Name    Nefm; Nef3; Nfm [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    475-678, Partial.
 Sequence    IAEELAASAK EEKEEAEEKE EEPEAEKSPV KSPEAKEEEE EGEKEEEEEG QEEEEEEDEG VKSDQAEEGG SEKEGSSEKD EGEQEEEEGE TEAEGEGEEA EAKEEKKIEG KVEEVAVKEE IKVEKPEKAK SPMPKSPVEE VKPKPEAKAG KGEQKEEEKV EEEKKEVTKE SPKEEKVEKK EEKPKDVADK KKAESPVKEK AVEE
 3D Structure    ModBase 3D Structure for P08553
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Nefm recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Nefm recombinant protein

   Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI/Uniprot data below describe general gene information for Nefm. It may not necessarily be applicable to this product.
 NCBI GI #    112363107
 NCBI GeneID    18040
 NCBI Accession #    NP_032717.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008691.2 [Other Products]
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 UniProt Primary Accession #    P08553 [Other Products]
 UniProt Secondary Accession #    Q0VDM8; Q3HRJ6; Q3TNS4; Q3TPK2; Q61961; Q8BQ20; A2VCT5 [Other Products]
 UniProt Related Accession #    P08553 [Other Products]
 Molecular Weight    95,916 Da
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 NCBI Official Full Name    neurofilament medium polypeptide
 NCBI Official Synonym Full Names    neurofilament, medium polypeptide
 NCBI Official Symbol    Nefm [Similar Products]
 NCBI Official Synonym Symbols   
Nfm; NF-M; Nef3; NF160; NF165
[Similar Products]
 NCBI Protein Information    neurofilament medium polypeptide; neurofilament-M; neurofilament 3, medium; neurofilament protein M; 160 kDa neurofilament protein; neurofilament triplet M protein
 UniProt Protein Name    Neurofilament medium polypeptide
 UniProt Synonym Protein Names   
160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein
 Protein Family    Neurofilament medium polypeptide
 UniProt Gene Name    Nefm [Similar Products]
 UniProt Synonym Gene Names    Nef3; Nfm; NF-M [Similar Products]
 UniProt Entry Name    NFM_MOUSE
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 UniProt Comments for Nefm    NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function.

Protein type: Cytoskeletal

Cellular Component: neuron projection; cytoskeleton; cell; axon; neurofilament; intermediate filament; intracellular; neuromuscular junction; myelin sheath

Molecular Function: structural molecule activity

Biological Process: neurofilament cytoskeleton organization and biogenesis; regulation of axon diameter; axon cargo transport; intermediate filament cytoskeleton organization and biogenesis; intermediate filament bundle assembly; microtubule cytoskeleton organization and biogenesis
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 Research Articles on Nefm    1. Data conclude that NF-H and NF-M C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Nefm recombinant proteinDiseases associated with Nefm recombinant protein
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with Nefm and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with Nefm and Brain Diseases
Organs/Tissues associated with Nefm recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with Nefm and Brain
 Embryonic Tissue Antibodies  >1 publications with Nefm and Embryonic Tissue
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