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Src recombinant protein :: Neuronal proto-oncogene tyrosine-protein kinase Src (Src) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS957954 Src recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $965 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,290 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,395 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,425 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,470 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,580 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,030 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,105 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,125 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,405 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,765 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuronal proto-oncogene tyrosine-protein kinase Src (Src), Recombinant Protein

 Also Known As   

Recombinant Mouse Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

 Product Gene Name   

Src recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-541\naa, Full Length of Mature Protein
 Sequence    GSNKSKPKDA SQRRRSLEPS ENVHGAGGAF PASQTPSKPA SADGHRGPSA AFVPPAAEPK LFGGFNSSDT VTSPQRAGPL AGGVTTFVAL YDYESRTETD LSFKKGERLQ IVNNTRKVDV REGDWWLAHS LSTGQTGYIP SNYVAPSDSI QAEEWYFGKI TRRESERLLL NAENPRGTFL VRESETTKGA YCLSVSDFDN AKGLNVKHYK IRKLDSGGFY ITSRTQFNSL QQLVAYYSKH ADGLCHRLTT VCPTSKPQTQ GLAKDAWEIP RESLRLEVKL GQGCFGEVWM GTWNGTTRVA IKTLKPGTMS PEAFLQEAQV MKKLRHEKLV QLYAVVSEEP IYIVTEYMNK GSLLDFLKGE TGKYLRLPQL VDMSAQIASG MAYVERMNYV HRDLRAANIL VGENLVCKVA DFGLARLIED NEYTARQGAK FPIKWTAPEA ALYGRFTIKS DVWSFGILLT ELTTKGRVPY PGMVNREVLD QVERGYRMPC PPECPESLHD LMCQCWRKEP EERPTFEYLQ AFLEDYFTST EPQYQPGENL
 3D Structure    ModBase 3D Structure for P05480
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Src recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Src recombinant protein

   This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. This protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
NCBI/Uniprot data below describe general gene information for Src. It may not necessarily be applicable to this product.
 NCBI GI #    70794809
 NCBI GeneID    20779
 NCBI Accession #    NP_001020566.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025395.2 [Other Products]
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 UniProt Primary Accession #    P05480 [Other Products]
 UniProt Secondary Accession #    Q2M4I4 [Other Products]
 UniProt Related Accession #    P05480 [Other Products]
 Molecular Weight    60,645 Da
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 NCBI Official Full Name    neuronal proto-oncogene tyrosine-protein kinase Src isoform 2
 NCBI Official Synonym Full Names    Rous sarcoma oncogene
 NCBI Official Symbol    Src [Similar Products]
 NCBI Official Synonym Symbols   
AW259666; pp60c-src
[Similar Products]
 NCBI Protein Information    neuronal proto-oncogene tyrosine-protein kinase Src
 UniProt Protein Name    Neuronal proto-oncogene tyrosine-protein kinase Src
 UniProt Synonym Protein Names   
Proto-oncogene c-Src; pp60c-src; p60-Src
 Protein Family    Neuronal proto-oncogene tyrosine-protein kinase
 UniProt Gene Name    Src [Similar Products]
 UniProt Synonym Gene Names    p60-Src [Similar Products]
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 UniProt Comments for Src    Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (PubMed:9344858). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation (). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Involved in anchorage-independent cell growth (). Required for podosome formation (PubMed:21525037).
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 Research Articles on Src    1. unlike c-fos-/- mice, c-src-/- mice demonstrated activated, mature osteoblasts, and parallel layers of cement lines in the superficial bone matrix, indicating the new bones were piled up to older bone.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Src recombinant proteinPathways associated with Src recombinant protein
 Reference Product  PubMed Publications
 Ptk2 recombinant protein  >541 publications with Src and Ptk2
 Shc1 recombinant protein  >245 publications with Src and Shc1
 Pdgfrb recombinant protein  >209 publications with Src and Pdgfrb
 Pxn recombinant protein  >162 publications with Src and Pxn
 Bcar1 recombinant protein  >152 publications with Src and Bcar1
 Ptk2b recombinant protein  >122 publications with Src and Ptk2b
 Khdrbs1 recombinant protein  >76 publications with Src and Khdrbs1
 Sos1 recombinant protein  >56 publications with Src and Sos1
 Dcc recombinant protein  >20 publications with Src and Dcc
 Adam15 recombinant protein  >15 publications with Src and Adam15
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
Diseases associated with Src recombinant proteinOrgans/Tissues associated with Src recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5671 publications with Src and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1833 publications with Src and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >1261 publications with Src and Carcinoma
 Breast Neoplasms Antibodies  >845 publications with Src and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >670 publications with Src and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >638 publications with Src and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >613 publications with Src and Cardiovascular Diseases
 Inflammation Antibodies  >592 publications with Src and Inflammation
 Vascular Diseases Antibodies  >576 publications with Src and Vascular Diseases
 Nervous System Diseases Antibodies  >536 publications with Src and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1738 publications with Src and Brain
 Bone Antibodies  >1128 publications with Src and Bone
 Kidney Antibodies  >1001 publications with Src and Kidney
 Lung Antibodies  >785 publications with Src and Lung
 Bone Marrow Antibodies  >615 publications with Src and Bone Marrow
 Embryonic Tissue Antibodies  >495 publications with Src and Embryonic Tissue
 Skin Antibodies  >336 publications with Src and Skin
 Eye Antibodies  >292 publications with Src and Eye
 Intestine Antibodies  >251 publications with Src and Intestine
 Ovary Antibodies  >208 publications with Src and Ovary
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