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NGAL recombinant protein :: Neurophil Gelatinase Associated Lipocalin (NGAL) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS343100 NGAL recombinant protein
Unit / Price
0.01 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurophil Gelatinase Associated Lipocalin (NGAL), Recombinant Protein

 Also Known As   

Neurophil Gelatinase Associated Lipocalin (NGAL) (Western Blot Control)

 Product Synonym Names    NGAL
 Product Gene Name   

NGAL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600181
 3D Structure    ModBase 3D Structure for P80188
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 Purity/Purification    >= 95% (SDS PAGE)
 Form/Format    Liquid
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of NGAL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NGAL recombinant protein

   The lipocalins are a family of around 25 proteins (including alpha 1-microglobulin and & b -lactoglobulin), which are characterized by their ability to bind small lipophilic substances in their hydrophobic core. They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke. Recombinant human NGAL is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
 Product Categories/Family for NGAL recombinant protein    Recombinant Proteins; Neutrophil Gelatinase Associated Lipocalin
NCBI/Uniprot data below describe general gene information for NGAL. It may not necessarily be applicable to this product.
 NCBI GI #    38455402
 NCBI GeneID    3934
 NCBI Accession #    NP_005555.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005564.4 [Other Products]
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 UniProt Primary Accession #    P80188 [Other Products]
 UniProt Secondary Accession #    P30150; Q5SYV9; Q5SYW0; Q6FGL5; Q92683; A6NII8; B4DWV4; B7ZAA2 [Other Products]
 UniProt Related Accession #    P80188 [Other Products]
 Molecular Weight    22,457 Da
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 NCBI Official Full Name    neutrophil gelatinase-associated lipocalin
 NCBI Official Synonym Full Names    lipocalin 2
 NCBI Official Symbol    LCN2 [Similar Products]
 NCBI Official Synonym Symbols   
p25; 24p3; MSFI; NGAL
[Similar Products]
 NCBI Protein Information    neutrophil gelatinase-associated lipocalin
 UniProt Protein Name    Neutrophil gelatinase-associated lipocalin
 UniProt Synonym Protein Names   
25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25
 UniProt Gene Name    LCN2 [Similar Products]
 UniProt Synonym Gene Names    HNL; NGAL; NGAL [Similar Products]
 UniProt Entry Name    NGAL_HUMAN
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 NCBI Summary for NGAL    This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
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 UniProt Comments for NGAL    LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extracellular region; extracellular space

Molecular Function: iron ion binding

Biological Process: cellular iron ion homeostasis; innate immune response; siderophore transport
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Product References and Citations for NGAL recombinant protein

   Elneihoum, A.M. et al. (1996) Stroke 27(10): 1734-38.
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 Research Articles on NGAL    1. higher serum concentrations in non-dipper and dipper hypertension patients compared to controls
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NGAL recombinant proteinPathways associated with NGAL recombinant protein
 Reference Product  PubMed Publications
 MMP9 recombinant protein  >39 publications with NGAL and MMP9
 HMOX1 recombinant protein  >19 publications with NGAL and HMOX1
 ERBB2 recombinant protein  >10 publications with NGAL and ERBB2
 TLR2 recombinant protein  >4 publications with NGAL and TLR2
 INS recombinant protein  >3 publications with NGAL and INS
 IL17A recombinant protein  >3 publications with NGAL and IL17A
 CDH1 recombinant protein  >1 publications with NGAL and CDH1
 LEP recombinant protein  >1 publications with NGAL and LEP
 LRP2 recombinant protein  >1 publications with NGAL and LRP2
 Products by Pathway  Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with NGAL recombinant proteinOrgans/Tissues associated with NGAL recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >828 publications with NGAL and Kidney Diseases
 Acute Kidney Injury Antibodies  >759 publications with NGAL and Acute Kidney Injury
 Renal Insufficiency Antibodies  >627 publications with NGAL and Renal Insufficiency
 Inflammation Antibodies  >384 publications with NGAL and Inflammation
 Cardiovascular Diseases Antibodies  >290 publications with NGAL and Cardiovascular Diseases
 Heart Diseases Antibodies  >153 publications with NGAL and Heart Diseases
 Necrosis Antibodies  >122 publications with NGAL and Necrosis
 Proteinuria Antibodies  >116 publications with NGAL and Proteinuria
 Disease Models, Animal Antibodies  >114 publications with NGAL and Disease Models, Animal
 Renal Insufficiency, Chronic Antibodies  >108 publications with NGAL and Renal Insufficiency, Chronic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1030 publications with NGAL and Blood
 Kidney Antibodies  >954 publications with NGAL and Kidney
 Liver Antibodies  >194 publications with NGAL and Liver
 Lung Antibodies  >99 publications with NGAL and Lung
 Bone Antibodies  >53 publications with NGAL and Bone
 Muscle Antibodies  >44 publications with NGAL and Muscle
 Connective Tissue Antibodies  >43 publications with NGAL and Connective Tissue
 Bone Marrow Antibodies  >40 publications with NGAL and Bone Marrow
 Intestine Antibodies  >32 publications with NGAL and Intestine
 Uterus Antibodies  >24 publications with NGAL and Uterus
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