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NT 3 recombinant protein :: Neurotrophin-3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142134 NT 3 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,585 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurotrophin-3 (NT 3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Neurotrophin-3

 Product Synonym Names    NT 3 Human; Neurotrophin-3 Human Recombinant; Neurotrophic factor; Nerve growth factor-2; NGF-2; HDNF; NT-3
 Product Gene Name   

NT 3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    YAEHKSHRGE YSVCDSESLW VTDKSSAIDI RGHQVTVLGE IKTGNSPVKQ YFYETRCKEA RPVKNGCRGI DDKHWNSQCK TSQTYVRALT SENNKLVGWR WIRIDTSCVC ALSRKIGRT
 OMIM    162660
 3D Structure    ModBase 3D Structure for P20783
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Neurotrophin-3 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 2.165 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of NT-3 as a Reference Standard.
 Biological Activity    The ED50 as determined by the dose-dependant induction of choline acetyl transferase in rat basal forebrain primary septal culture was found between 20-50ng/ml, corresponding to a Specific Activity of 20,000-50,000IU/mg.
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 Preparation and Storage    Lyophilized NGF2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution NGF-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of NT 3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NT 3 recombinant protein

   Description: Neurotrophin-3 Human Recombinant produced in E Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.The NT-3 is purified by proprietary chromatographic techniques.

Introduction: NT3 a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
 Product Categories/Family for NT 3 recombinant protein    CYTOKINES AND GROWTH FACTORS; Neurotrophins
NCBI/Uniprot data below describe general gene information for NT 3. It may not necessarily be applicable to this product.
 NCBI GI #    156630995
 NCBI GeneID    4908
 NCBI Accession #    NP_001096124.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001102654.1 [Other Products]
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 UniProt Primary Accession #    P20783 [Other Products]
 UniProt Secondary Accession #    Q6FH50; B7Z1T5 [Other Products]
 UniProt Related Accession #    P20783 [Other Products]
 Molecular Weight    30,800 Da
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 NCBI Official Full Name    neurotrophin-3 isoform 1 preproprotein
 NCBI Official Synonym Full Names    neurotrophin 3
 NCBI Official Symbol    NTF3 [Similar Products]
 NCBI Official Synonym Symbols   
NT3; HDNF; NGF2; NT-3; NGF-2
[Similar Products]
 NCBI Protein Information    neurotrophin-3; nerve growth factor 2; neurotrophic factor
 UniProt Protein Name    Neurotrophin-3
 UniProt Synonym Protein Names   
HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
 Protein Family    Neurotrophin
 UniProt Gene Name    NTF3 [Similar Products]
 UniProt Synonym Gene Names    NT-3; NGF-2 [Similar Products]
 UniProt Entry Name    NTF3_HUMAN
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 NCBI Summary for NT 3    The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NT 3    NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; receptor binding; chemoattractant activity

Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; regulation of neuron differentiation; activation of MAPK activity; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; cell-cell signaling; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; nervous system development; negative regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; nerve development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; brain development; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
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 Research Articles on NT 3    1. NT-3 expression was found in axons of olfactory bulb.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NT 3 recombinant proteinPathways associated with NT 3 recombinant protein
 Reference Product  PubMed Publications
 BDNF recombinant protein  >20 publications with NT 3 and BDNF
 NTRK3 recombinant protein  >5 publications with NT 3 and NTRK3
 NTRK1 recombinant protein  >4 publications with NT 3 and NTRK1
 NTRK2 recombinant protein  >4 publications with NT 3 and NTRK2
 NGFR recombinant protein  >3 publications with NT 3 and NGFR
 HRAS recombinant protein  >1 publications with NT 3 and HRAS
 CREB1 recombinant protein  >1 publications with NT 3 and CREB1
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Trk Receptor Signaling Mediated By The MAPK Pathway antibodies  Trk Receptor Signaling Mediated By The MAPK Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram
Diseases associated with NT 3 recombinant proteinOrgans/Tissues associated with NT 3 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with NT 3 and Nervous System Diseases
 Hearing Loss Antibodies  >4 publications with NT 3 and Hearing Loss
 Schizophrenia Antibodies  >2 publications with NT 3 and Schizophrenia
 Neoplasm Metastasis Antibodies  >1 publications with NT 3 and Neoplasm Metastasis
 Hypertension Antibodies  >1 publications with NT 3 and Hypertension
 Memory Disorders Antibodies  >1 publications with NT 3 and Memory Disorders
 Disease Models, Animal Antibodies  >1 publications with NT 3 and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with NT 3 and Learning Disorders
 Inflammation Antibodies  >1 publications with NT 3 and Inflammation
 Nerve Degeneration Antibodies  >1 publications with NT 3 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with NT 3 and Brain
 Testis Antibodies  >3 publications with NT 3 and Testis
 Embryonic Tissue Antibodies  >3 publications with NT 3 and Embryonic Tissue
 Eye Antibodies  >2 publications with NT 3 and Eye
 Ovary Antibodies  >1 publications with NT 3 and Ovary
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