NP_006170.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28.1 kDa
NCBI Official Full Name
neurotrophin-4 preproprotein
NCBI Official Synonym Full Names
neurotrophin 4
NCBI Official Synonym Symbols
NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5 [Similar Products]
NCBI Protein Information
neurotrophin-4
UniProt Protein Name
Neurotrophin-4
UniProt Synonym Protein Names
Neurotrophin-5; NT-5; Neutrophic factor 4
UniProt Synonym Gene Names
NCBI Summary for NTF4
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
UniProt Comments for NTF4
NT-4/5: Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family.
Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasmic vesicle; endoplasmic reticulum lumen; extracellular region
Molecular Function: growth factor activity; neurotrophin p75 receptor binding; protein binding
Biological Process: adult locomotory behavior; cell-cell signaling; epidermis development; ganglion mother cell fate determination; long-term memory; negative regulation of neuron apoptosis; neurite morphogenesis; regulation of neuron differentiation; sensory organ boundary specification; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Glaucoma 1, Open Angle, O
Research Articles on NTF4
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Products associated with NTF4 active protein
Pathways associated with NTF4 active protein
Diseases associated with NTF4 active protein
Organs/Tissues associated with NTF4 active protein
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