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DEFA3 recombinant protein :: Neutrophil defensin 3 (DEFA3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955711
SDS-PAGE
Unit / Price
0.05 mg (E-Coli)  /  $445 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $590 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $625 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $650 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $785 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $845 +1 FREE 8GB USB
1 mg (E-Coli)  /  $920 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $955 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,025 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,435 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,565 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,930 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neutrophil defensin 3 (DEFA3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Neutrophil defensin 3 (DEFA3)

 Product Synonym Names    Neutrophil defensin 3; Defensin, alpha 3; HNP-3; HP-3; HP3Cleaved into the following 2 chains:; 1. HP 3-56; 2. Neutrophil defensin 2; HNP-2; HP-2; HP2
 Product Gene Name   

DEFA3 recombinant protein

[Similar Products]
 Product Synonym Gene Name    DEFA3; DEF3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    39-94aa; Full length protein
 Sequence    DI PEVVVSLAWD ESLAPKHPGS RKNMDCYCRI PACIAGERRY GTCIYQGRLW AFCC
 OMIM    604522
 3D Structure    ModBase 3D Structure for P59666
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DEFA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for DEFA3 recombinant protein

   Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
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 SDS-PAGE of DEFA3 recombinant protein    DEFA3 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for DEFA3. It may not necessarily be applicable to this product.
 NCBI GI #    4885179
 NCBI GeneID    1668
 NCBI Accession #    NP_005208.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005217.3 [Other Products]
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 UniProt Primary Accession #    P59666 [Other Products]
 UniProt Secondary Accession #    P11479; Q14125 [Other Products]
 UniProt Related Accession #    P59666 [Other Products]
 Molecular Weight    8kD
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 NCBI Official Full Name    neutrophil defensin 3 preproprotein
 NCBI Official Synonym Full Names    defensin, alpha 3, neutrophil-specific
 NCBI Official Symbol    DEFA3 [Similar Products]
 NCBI Official Synonym Symbols   
HP3; DEF3; HNP3; HP-3; HNP-3
[Similar Products]
 NCBI Protein Information    neutrophil defensin 3; neutrophil peptide 3; defensin 3, neutrophil-specific
 UniProt Protein Name    Neutrophil defensin 3
 UniProt Synonym Protein Names   
Defensin, alpha 3; HNP-3; HP-3; HP3
 Protein Family    Neutrophil defensin
 UniProt Gene Name    DEFA3 [Similar Products]
 UniProt Synonym Gene Names    DEF3; HP-3; HP3; HP-2; HP2 [Similar Products]
 UniProt Entry Name    DEF3_HUMAN
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 NCBI Summary for DEFA3    Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, May 2010]
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 UniProt Comments for DEFA3    defensin, alpha 3: Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: defense response to Gram-positive bacterium; estrogen receptor signaling pathway; innate immune response in mucosa; killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to virus; defense response to fungus
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 Research Articles on DEFA3    1. A decrease in salivary HNP 1-3 levels might be a biological factor for predisposition to oral ulcers in patients with Behcet disease and oral infection in healthy patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DEFA3 recombinant proteinPathways associated with DEFA3 recombinant protein
 Reference Product  PubMed Publications
 DEFA1 recombinant protein  >11 publications with DEFA3 and DEFA1
 CAMP recombinant protein  >1 publications with DEFA3 and CAMP
 Products by Pathway  Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with DEFA3 recombinant proteinOrgans/Tissues associated with DEFA3 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with DEFA3 and Inflammation
 Blood Coagulation Disorders Antibodies  >1 publications with DEFA3 and Blood Coagulation Disorders
 Intestinal Diseases Antibodies  >1 publications with DEFA3 and Intestinal Diseases
 Recurrence Antibodies  >1 publications with DEFA3 and Recurrence
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with DEFA3 and Bone
 Connective Tissue Antibodies  >4 publications with DEFA3 and Connective Tissue
 Heart Antibodies  >3 publications with DEFA3 and Heart
 Muscle Antibodies  >3 publications with DEFA3 and Muscle
 Brain Antibodies  >3 publications with DEFA3 and Brain
 Vascular Antibodies  >2 publications with DEFA3 and Vascular
 Embryonic Tissue Antibodies  >2 publications with DEFA3 and Embryonic Tissue
 Ear Antibodies  >1 publications with DEFA3 and Ear
 Kidney Antibodies  >1 publications with DEFA3 and Kidney
 Umbilical Cord Antibodies  >1 publications with DEFA3 and Umbilical Cord
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