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NNMT recombinant protein :: Nicotinamide N-Methyltransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143908 NNMT recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nicotinamide N-Methyltransferase (NNMT), Recombinant Protein

 Also Known As   

Recombinant Human Nicotinamide N-Methyltransferase

 Product Synonym Names    NNMT Human; Nicotinamide N-Methyltransferase Human Recombinant; Nicotineamide N-methyltransferase; NNMT
 Product Gene Name   

NNMT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL
 OMIM    600008
 3D Structure    ModBase 3D Structure for P40261
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The NNMT solution contains 20mM Tris pH 8.0 & 20% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    NNMT although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of NNMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NNMT recombinant protein

   Description: NNMT Human Recombinant fused with 20 amino acid His-Tag tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing a total of 284 amino acids (1-264 a.a.) and having a molecular mass of 31.7 kDa.The NNMT is purified by proprietary chromatographic techniques.

Introduction: NNMT is part of the family of transferases, especially those transferring one-carbon group methyltransferases. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is significant for biotransformation of many drugs and xenobiotic compounds. NNMT is accountable for the enzymatic activity which uses S-adenosyl methionine as the methyl donor. NNMT expression is related with tumor stage and DFS time in hepatocellular carcinoma cases. NNMT is a good candidate as a tumor marker of various kinds of cancers. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
 Product Categories/Family for NNMT recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for NNMT. It may not necessarily be applicable to this product.
 NCBI GI #    5453790
 NCBI GeneID    4837
 NCBI Accession #    NP_006160.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006169.2 [Other Products]
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 UniProt Primary Accession #    P40261 [Other Products]
 UniProt Related Accession #    P40261 [Other Products]
 Molecular Weight    29,574 Da
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 NCBI Official Full Name    nicotinamide N-methyltransferase
 NCBI Official Synonym Full Names    nicotinamide N-methyltransferase
 NCBI Official Symbol    NNMT [Similar Products]
 NCBI Protein Information    nicotinamide N-methyltransferase
 UniProt Protein Name    Nicotinamide N-methyltransferase
 Protein Family    Nicotinamide N-methyltransferase
 UniProt Gene Name    NNMT [Similar Products]
 UniProt Entry Name    NNMT_HUMAN
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 NCBI Summary for NNMT    N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NNMT    NNMT: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Belongs to the NNMT/PNMT/TEMT family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.1.1.1; Methyltransferase

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cytosol

Molecular Function: nicotinamide N-methyltransferase activity

Biological Process: response to drug; methylation; organ regeneration; xenobiotic metabolic process; response to organic nitrogen
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 Research Articles on NNMT    1. NNMT enhances the capacity of tumorigenesis associated with the inhibition of cell apoptosis and the promotion of cell cycle progression in human colorectal cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NNMT recombinant proteinPathways associated with NNMT recombinant protein
 Reference Product  PubMed Publications
 MTHFR recombinant protein  >11 publications with NNMT and MTHFR
 AHCY recombinant protein  >3 publications with NNMT and AHCY
 MMP2 recombinant protein  >2 publications with NNMT and MMP2
 STAT3 recombinant protein  >1 publications with NNMT and STAT3
 AOX1 recombinant protein  >1 publications with NNMT and AOX1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
 Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies  Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram
 Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway antibodies  Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway Diagram
 Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway antibodies  Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway Diagram
 Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway antibodies  Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway Diagram
 Defective UGT1A1 Causes Hyperbilirubinemia Pathway antibodies  Defective UGT1A1 Causes Hyperbilirubinemia Pathway Diagram
Diseases associated with NNMT recombinant proteinOrgans/Tissues associated with NNMT recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >38 publications with NNMT and Carcinoma
 Adenocarcinoma Antibodies  >15 publications with NNMT and Adenocarcinoma
 Liver Diseases Antibodies  >10 publications with NNMT and Liver Diseases
 Kidney Diseases Antibodies  >9 publications with NNMT and Kidney Diseases
 Liver Neoplasms Antibodies  >8 publications with NNMT and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >7 publications with NNMT and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >6 publications with NNMT and Lung Neoplasms
 Breast Neoplasms Antibodies  >6 publications with NNMT and Breast Neoplasms
 Lung Diseases Antibodies  >5 publications with NNMT and Lung Diseases
 Inflammation Antibodies  >4 publications with NNMT and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >34 publications with NNMT and Liver
 Brain Antibodies  >18 publications with NNMT and Brain
 Kidney Antibodies  >12 publications with NNMT and Kidney
 Lung Antibodies  >8 publications with NNMT and Lung
 Mouth Antibodies  >6 publications with NNMT and Mouth
 Heart Antibodies  >5 publications with NNMT and Heart
 Adipose Tissue Antibodies  >5 publications with NNMT and Adipose Tissue
 Uterus Antibodies  >4 publications with NNMT and Uterus
 Ascites Antibodies  >4 publications with NNMT and Ascites
 Pancreas Antibodies  >3 publications with NNMT and Pancreas
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