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NMNAT2 recombinant protein :: Nicotinamide Nucleotide Adenylyltransferase 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144009 NMNAT2 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2), Recombinant Protein

 Also Known As   

Recombinant Human Nicotinamide Nucleotide Adenylyltransferase 2

 Product Synonym Names    NMNAT2 Human; Nicotinamide Nucleotide Adenylyltransferase 2 Human Recombinant; Nicotinamide Nucleotide Adenylyltransferase 2; C1orf15; Nicotinate-Nucleotide Adenylyltransferase 2; NaMN Adenylyltransferase 2; NMN Adenylyltransferase 2; PNAT2; KIAA0479; Chromosome 1 Open Reading Frame 15; Nicotinamide Mononucleotide Adenylyltransferase 2; Pyridine Nucleotide Adenylyltransferase 2; EC 2.7.7.1; EC 2.7.7.18
 Product Gene Name   

NMNAT2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MTETTK THVI LLACGSFNPI TKGHIQMFER ARDYLHKTGR FIVIGGIVSP VHDSYGKQGL VSSRHRLIMC QLAVQNSDWI RVDPWECYQD TWQTTCSVLE HHRDLMKRVT GCILSNVNTP SMTPVIGQPQ NETPQPIYQN SNVATKPTAA KILGKVGESL SRICCVRPPV ERFTFVDENA NLGTVMRYEE IELRILLLCG SDLLESFCIP GLWNEADMEV IVGDFGIVVV PRDAADTDRI MNHSSILRKY KNNIMVVKDD INHPMSVVSS TKSRLALQHG DGHVVDYLSQ PVIDYILKSQ LYINASG
 OMIM    608701
 3D Structure    ModBase 3D Structure for Q9BZQ4
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 Host    E Coli
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 Purity/Purification    Greater than 85.0% as determined by SDS-PAGE.
 Form/Format    NMNAT2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Sterile Filtered clear solution.
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 Biological Activity    Specific activity: > 500 pmol/min/ug. One unit will convert 1.0 pmole of beta-NADH per minute to beta-NAD at PH 8.0 at 37 degree C.
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 Other Notes    Small volumes of NMNAT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NMNAT2 recombinant protein

   Description: NMNAT2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (1-307 a.a) and having a molecular mass of 36.6kDa.NMNAT2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Nicotinamide Nucleotide Adenylyltransferase 2, also known as NMNAT2 is a member of the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze a vital step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; NMNAT2 is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for NMNAT2. Among the diseases associated with NMNAT2 are tauopathy, and systemic lupus erythematosus.
 Product Categories/Family for NMNAT2 recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for NMNAT2. It may not necessarily be applicable to this product.
 NCBI GI #    24307989
 NCBI GeneID    23057
 NCBI Accession #    NP_055854.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015039.3 [Other Products]
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 UniProt Primary Accession #    Q9BZQ4 [Other Products]
 UniProt Secondary Accession #    O75067; Q5T1Q3; Q8WU99; Q96QW1 [Other Products]
 UniProt Related Accession #    Q9BZQ4 [Other Products]
 Molecular Weight    34,015 Da
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 NCBI Official Full Name    nicotinamide mononucleotide adenylyltransferase 2 isoform 1
 NCBI Official Synonym Full Names    nicotinamide nucleotide adenylyltransferase 2
 NCBI Official Symbol    NMNAT2 [Similar Products]
 NCBI Official Synonym Symbols   
PNAT2; C1orf15
[Similar Products]
 NCBI Protein Information    nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 2; pyridine nucleotide adenylyltransferase 2
 UniProt Protein Name    Nicotinamide mononucleotide adenylyltransferase 2
 UniProt Synonym Protein Names   
Nicotinate-nucleotide adenylyltransferase 2 (EC:2.7.7.18); NaMN adenylyltransferase 2
 UniProt Gene Name    NMNAT2 [Similar Products]
 UniProt Synonym Gene Names    C1orf15; KIAA0479; NMN adenylyltransferase 2; NaMN adenylyltransferase 2 [Similar Products]
 UniProt Entry Name    NMNA2_HUMAN
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 NCBI Summary for NMNAT2    This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NMNAT2    NMNAT2: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Belongs to the eukaryotic NMN adenylyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.7.7.18; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.1

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: Golgi membrane; Golgi apparatus; late endosome; synapse; trans-Golgi network

Molecular Function: nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process
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 Research Articles on NMNAT2    1. Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NMNAT2 recombinant proteinDiseases associated with NMNAT2 recombinant protein
 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with NMNAT2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with NMNAT2 and Disease Models, Animal
 Hypertrophy Antibodies  >1 publications with NMNAT2 and Hypertrophy
 Cardiovascular Diseases Antibodies  >1 publications with NMNAT2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >1 publications with NMNAT2 and Lung Neoplasms
Organs/Tissues associated with NMNAT2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with NMNAT2 and Brain
 Embryonic Tissue Antibodies  >4 publications with NMNAT2 and Embryonic Tissue
 Muscle Antibodies  >3 publications with NMNAT2 and Muscle
 Eye Antibodies  >1 publications with NMNAT2 and Eye
 Blood Antibodies  >1 publications with NMNAT2 and Blood
 Heart Antibodies  >1 publications with NMNAT2 and Heart
 Lung Antibodies  >1 publications with NMNAT2 and Lung
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