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NME2 recombinant protein :: Non-Metastatic Cells 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143797 NME2 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Non-Metastatic Cells 2 (NME2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Non-Metastatic Cells 2

 Product Synonym Names    NME2 Human; Non-Metastatic Cells 2 Human Recombinant; Nucleoside diphosphate kinase B; NDPK-B; NDPKB; NM23-H2; NM23B; EC 2.7.4.6; NDP kinase B; C-myc purine-binding transcription factor PUF; NDK B; NME2; puf; MGC111212
 Product Gene Name   

NME2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YE
 OMIM    156491
 3D Structure    ModBase 3D Structure for P22392
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The NME2 protein solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    NME2 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of NME2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NME2 recombinant protein

   Description: NME2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids (1-152 a.a.) and having a molecular mass of 17.2kDa. The NME2 is purified by conventional chromatography.

Introduction: NME2 takes an important part in the synthesis of nucleoside triphosphates other than ATP. NME2 negatively controls Rho activity by interacting with AKAP13/LBC. NME2 acts as a transcriptional activator of the MYC gene. NME2 binds DNA non-specifically. NME2 is a heterodimeric enzyme functioning as a nucleoside diphosphate kinase. NME1 and NME2 contain 152 amino acids, A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases participate in the synthesis of nucleoside triphosphates, and NM23 is involved in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways.
 Product Categories/Family for NME2 recombinant protein    PROTEIN KINASES; Recombinant Proteins; Non-Metastatic Cells
NCBI/Uniprot data below describe general gene information for NME2. It may not necessarily be applicable to this product.
 NCBI GI #    66392203
 NCBI GeneID    654364
 NCBI Accession #    NP_001018146.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018136.2 [Other Products]
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 UniProt Primary Accession #    P22392 [Other Products]
 UniProt Secondary Accession #    Q1WM23; Q6LCT6; A8MWA3 [Other Products]
 Molecular Weight    30,137 Da
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 NCBI Official Full Name    NME1-NME2 protein
 NCBI Official Synonym Full Names    NME1-NME2 readthrough
 NCBI Official Symbol    NME1-NME2 [Similar Products]
 NCBI Official Synonym Symbols   
NMELV; NM23-LV
[Similar Products]
 NCBI Protein Information    NME1-NME2 protein; NME1-NME2 readthrough transcript
 UniProt Protein Name    Nucleoside diphosphate kinase B
 UniProt Synonym Protein Names   
C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2
 UniProt Gene Name    NME2 [Similar Products]
 UniProt Synonym Gene Names    NM23B; NDK B; NDP kinase B [Similar Products]
 UniProt Entry Name    NDKB_HUMAN
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 NCBI Summary for NME2    This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
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 UniProt Comments for NME2    NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; Kinase, nucleoside diphosphate; Nuclear receptor co-regulator; EC 2.7.13.3; Kinase, other; Nucleotide Metabolism - purine; EC 2.7.4.6; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: ruffle; centrosome; focal adhesion; mitochondrion; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; intermediate filament; nucleus; cytosol

Molecular Function: protein binding; gamma-tubulin binding; metal ion binding; protein histidine kinase activity; intermediate filament binding; nucleoside diphosphate kinase activity; transcription factor activity; protein kinase binding; ATP binding; single-stranded DNA binding

Biological Process: GTP biosynthetic process; integrin-mediated signaling pathway; peptidyl-histidine phosphorylation; response to cAMP; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of myeloid leukocyte differentiation; UTP biosynthetic process; hippocampus development; nucleoside diphosphate phosphorylation; response to testosterone stimulus; CTP biosynthetic process; regulation of transcription, DNA-dependent; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; cell adhesion; positive regulation of epithelial cell proliferation; regulation of epidermis development; response to amine stimulus; positive regulation of keratinocyte differentiation; purine nucleotide metabolic process; negative regulation of apoptosis
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 Research Articles on NME2    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NME2 recombinant proteinDiseases associated with NME2 recombinant protein
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with NME2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with NME2 and Lung Neoplasms
 Anemia Antibodies  >1 publications with NME2 and Anemia
 Neoplasm Metastasis Antibodies  >1 publications with NME2 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with NME2 and Carcinoma, Hepatocellular
Organs/Tissues associated with NME2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with NME2 and Lung
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