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NCOA3 recombinant protein :: Nuclear Receptor Coactivator 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031278 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $265 +1 FREE 8GB USB
0.1 mg  /  $415 +1 FREE 8GB USB
0.2 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $990 +1 FREE 8GB USB
1 mg  /  $1,465 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear Receptor Coactivator 3 (NCOA3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Nuclear Receptor Coactivator 3 (NCOA3)

 Product Gene Name   

NCOA3 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Nuclear Receptor Coactivator 3 (MBS2027621)
Antigen: Nuclear Receptor Coactivator 3 (MBS2031278)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    E.coli
 Species Reactivity    Human
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 Purity/Purification    > 97%
 Form/Format    100mM NaHCO3, 500mM NaCl, pH8.3, containing 0.01% SKL, 5% Trehalose and Proclin300.
 Concentration    Original Concentration: 200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Gly1023~Ala1304
 Tags    N-terminal His Tag
 Subcellular Location    Nucleus, Cytoplasm
 Traits    Freeze-dried powder
 Predicted isoelectric point    7.2
 Predicted Molecular Mass    35.3KDa
 Accurate Molecular Mass    40kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:
1.Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post-translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of NCOA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for NCOA3 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of NCOA3 recombinant protein    NCOA3 recombinant protein Sequence image
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 Gene Sequencing (Extract) of NCOA3 recombinant protein    NCOA3 recombinant protein Gene Sequencing (Extract) image
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 SDS-PAGE of NCOA3 recombinant protein    NCOA3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for NCOA3. It may not necessarily be applicable to this product.
 NCBI GI #    118026946
 NCBI GeneID    17979
 NCBI Accession #    NP_032705.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008679.3 [Other Products]
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 UniProt Secondary Accession #    Q9CRD5 [Other Products]
 UniProt Related Accession #    O09000 [Other Products]
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 NCBI Official Full Name    nuclear receptor coactivator 3
 NCBI Official Synonym Full Names    nuclear receptor coactivator 3
 NCBI Official Symbol    Ncoa3 [Similar Products]
 NCBI Official Synonym Symbols   
Actr; Aib1; Rac3; Src3; pCip; Tram1; p/Cip; KAT13B; Tram-1; bHLHe42; AW321064; 2010305B15Rik
[Similar Products]
 NCBI Protein Information    nuclear receptor coactivator 3
 UniProt Protein Name    Nuclear receptor coactivator 3
 UniProt Synonym Protein Names   
Amplified in breast cancer-1 protein homolog; AIB-1; CBP-interacting protein; p/CIP; pCIP; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; ACTR; TRAM-1
 Protein Family    Nuclear receptor coactivator
 UniProt Gene Name    Ncoa3 [Similar Products]
 UniProt Synonym Gene Names    Aib1; Pcip; Rac3; Tram1; NCoA-3; AIB-1; p/CIP; pCIP; RAC-3; SRC-3; ACTR; TRAM-1 [Similar Products]
 UniProt Entry Name    NCOA3_MOUSE
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 UniProt Comments for NCOA3    SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; EC 2.3.1.48; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator

Cellular Component: nucleoplasm; Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; protein dimerization activity; peroxisome proliferator activated receptor binding; transcription coactivator activity; protein N-terminus binding; transferase activity; signal transducer activity; histone acetyltransferase activity; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; transferase activity, transferring acyl groups; protein complex binding; estrogen receptor binding; chromatin binding; nuclear hormone receptor binding

Biological Process: developmental growth; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of steroid hormone receptor signaling pathway; multicellular organism growth; positive regulation of estrogen receptor signaling pathway; vagina development; signal transduction; positive regulation of cell growth; cellular response to hormone stimulus; regulation of transcription, DNA-dependent; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; positive regulation of keratinocyte differentiation; negative regulation of apoptosis
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 Research Articles on NCOA3    1. SRC-3 is a target for inhibiting aggressive prostate cancer containing neuroendocrine tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NCOA3 recombinant proteinPathways associated with NCOA3 recombinant protein
 Reference Product  PubMed Publications
 Crebbp recombinant protein  >23 publications with NCOA3 and Crebbp
 Carm1 recombinant protein  >13 publications with NCOA3 and Carm1
 Ncor1 recombinant protein  >11 publications with NCOA3 and Ncor1
 Ncor2 recombinant protein  >10 publications with NCOA3 and Ncor2
 Ep300 recombinant protein  >8 publications with NCOA3 and Ep300
 Ppargc1a recombinant protein  >2 publications with NCOA3 and Ppargc1a
 Med1 recombinant protein  >2 publications with NCOA3 and Med1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 MAPK Family Signaling Cascades Pathway antibodies  MAPK Family Signaling Cascades Pathway Diagram
 MAPK6/MAPK4 Signaling Pathway antibodies  MAPK6/MAPK4 Signaling Pathway Diagram
 Mus Musculus Biological Processes Pathway antibodies  Mus Musculus Biological Processes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
 Transcriptional Regulation Of Adipocyte Differentiation In 3T3-L1 Pre-adipocytes Pathway antibodies  Transcriptional Regulation Of Adipocyte Differentiation In 3T3-L1 Pre-adipocytes Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram
Organs/Tissues associated with NCOA3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with NCOA3 and Blood
 Prostate Antibodies  >30 publications with NCOA3 and Prostate
 Liver Antibodies  >29 publications with NCOA3 and Liver
 Thyroid Antibodies  >21 publications with NCOA3 and Thyroid
 Lymph Node Antibodies  >19 publications with NCOA3 and Lymph Node
 Lung Antibodies  >17 publications with NCOA3 and Lung
 Brain Antibodies  >16 publications with NCOA3 and Brain
 Muscle Antibodies  >16 publications with NCOA3 and Muscle
 Mammary Gland Antibodies  >14 publications with NCOA3 and Mammary Gland
 Bone Antibodies  >13 publications with NCOA3 and Bone
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