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NFKB2 recombinant protein :: Nuclear factor NF-kappa-B p100 subunit (NFKB2), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS718042 NFKB2 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear factor NF-kappa-B p100 subunit (NFKB2), partial, Recombinant Protein

 Also Known As   

Recombinant Chicken Nuclear factor NF-kappa-B p100 subunit (NFKB2), partial

 Product Synonym Names    Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; Lyt-10; Nuclear factor NF-kappa-B p97 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2Cleaved into the following chain:; 1. Nuclear factor NF-kappa-B p52 subunit
 Product Gene Name   

NFKB2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P98150
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Gallus gallus (Chicken)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NFKB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NFKB2. It may not necessarily be applicable to this product.
 NCBI GI #    45383335
 NCBI GeneID    386574
 NCBI Accession #    NP_989744.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_204413.1 [Other Products]
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 UniProt Primary Accession #    P98150 [Other Products]
 UniProt Related Accession #    P98150 [Other Products]
 Molecular Weight    99,667 Da
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 NCBI Official Full Name    nuclear factor NF-kappa-B p100 subunit
 NCBI Official Synonym Full Names    nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
 NCBI Official Symbol    NFKB2 [Similar Products]
 NCBI Protein Information    nuclear factor NF-kappa-B p100 subunit; lyt-10; DNA-binding factor KBF2; nuclear factor NF-kappa-B p97 subunit
 UniProt Protein Name    Nuclear factor NF-kappa-B p100 subunit
 UniProt Synonym Protein Names   
DNA-binding factor KBF2; Lyt-10; Nuclear factor NF-kappa-B p97 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2Cleaved into the following chain:Nuclear factor NF-kappa-B p52 subunitAlternative name(s):Nuclear factor NF-kappa-B p50B subunit
 Protein Family    Nuclear factor
 UniProt Gene Name    NFKB2 [Similar Products]
 UniProt Entry Name    NFKB2_CHICK
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 UniProt Comments for NFKB2    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In concert with RELB, may play a role in the regulation of the circadian clock ().
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 Research Articles on NFKB2    1. The genes for IL9, IL4, CCL4 and NFKB were found to be associated to plumage condition, revealing relationships between the immune system and behaviour.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NFKB2 recombinant proteinPathways associated with NFKB2 recombinant protein
 Reference Product  PubMed Publications
 IKBKB recombinant protein  >59 publications with NFKB2 and IKBKB
 CHUK recombinant protein  >21 publications with NFKB2 and CHUK
 IL1B recombinant protein  >6 publications with NFKB2 and IL1B
 NFKBIA recombinant protein  >3 publications with NFKB2 and NFKBIA
 CREBBP recombinant protein  >2 publications with NFKB2 and CREBBP
 MAP3K14 recombinant protein  >2 publications with NFKB2 and MAP3K14
 IL12B recombinant protein  >1 publications with NFKB2 and IL12B
 MAP3K8 recombinant protein  >1 publications with NFKB2 and MAP3K8
 EP300 recombinant protein  >1 publications with NFKB2 and EP300
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
Diseases associated with NFKB2 recombinant proteinOrgans/Tissues associated with NFKB2 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >74 publications with NFKB2 and Necrosis
 Immune System Diseases Antibodies  >60 publications with NFKB2 and Immune System Diseases
 Inflammation Antibodies  >52 publications with NFKB2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >19 publications with NFKB2 and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >14 publications with NFKB2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >13 publications with NFKB2 and Breast Neoplasms
 Lung Diseases Antibodies  >11 publications with NFKB2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >9 publications with NFKB2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >7 publications with NFKB2 and Nervous System Diseases
 Liver Diseases Antibodies  >6 publications with NFKB2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >15 publications with NFKB2 and Spleen
 Embryonic Tissue Antibodies  >6 publications with NFKB2 and Embryonic Tissue
 Head Antibodies  >2 publications with NFKB2 and Head
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