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RORC recombinant protein :: Nuclear receptor ROR-gamma (RORC) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS961972
Unit / Price
0.01 mg (E-Coli)  /  $150 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,010 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,140 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,370 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,390 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,450 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,550 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,075 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,100 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,360 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,725 +3 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear receptor ROR-gamma (RORC), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Nuclear receptor ROR-gamma (RORC)

 Product Synonym Names    Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma
 Product Gene Name   

RORC recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS961972 COA    COA PDF
 Sequence Positions    1-518. Full length.
 OMIM    602943
 3D Structure    ModBase 3D Structure for P51449
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RORC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RORC recombinant protein

   Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1. Regulates the rhythmic expression of PROX1 and promotes its nuclear localization.
 Product Categories/Family for RORC recombinant protein    Transcription
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 SDS-PAGE of RORC recombinant protein    RORC recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for RORC. It may not necessarily be applicable to this product.
 NCBI GI #    48255918
 NCBI GeneID    6097
 NCBI Accession #    NP_001001523.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001523.1 [Other Products]
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 UniProt Primary Accession #    P51449 [Other Products]
 UniProt Secondary Accession #    Q5SZR9; Q8N5V7; Q8NCY8 [Other Products]
 UniProt Related Accession #    P51449 [Other Products]
 Molecular Weight    74.2kD
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 NCBI Official Full Name    nuclear receptor ROR-gamma isoform b
 NCBI Official Synonym Full Names    RAR related orphan receptor C
 NCBI Official Symbol    RORC [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    nuclear receptor ROR-gamma
 UniProt Protein Name    Nuclear receptor ROR-gamma
 UniProt Synonym Protein Names   
Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma
 Protein Family    Nuclear receptor
 UniProt Gene Name    RORC [Similar Products]
 UniProt Synonym Gene Names    NR1F3; RORG; RZRG [Similar Products]
 UniProt Entry Name    RORG_HUMAN
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 NCBI Summary for RORC    The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RORC    RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; oxysterol binding; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; zinc ion binding

Biological Process: circadian regulation of gene expression; gene expression; intracellular receptor-mediated signaling pathway; lymph node development; Peyer's patch development; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; steroid hormone mediated signaling; T-helper cell differentiation; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process

Disease: Immunodeficiency 42
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Product References and Citations for RORC recombinant protein

   ROR gamma the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.Hirose T., Smith R.J., Jetten A.M.Biochem. Biophys. Res. Commun. 205:1976-1983(1994) The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006) TGF-beta-induced Foxp3 inhibits T(H) 17 cell differentiation by antagonizing RORgammat function.Zhou L., Lopes J.E., Chong M.M., Ivanov I.I., Min R., Victora G.D., Shen Y., Du J., Rubtsov Y.P., Rudensky A.Y., Ziegler S.F., Littman D.R.Nature 453:236-240(2008) Retinoid-related orphan receptors (RORs) critical roles in development, immunity, circadian rhythm, and cellular metabolism.Jetten A.M.Nucl. Recept. Signal. 7:3-35(2009) A second class of nuclear receptors for oxysterols Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol) .Wang Y., Kumar N., Crumbley C., Griffin P.R., Burris T.P.Biochim. Biophys. Acta 1801:917-923(2010) Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.J. Biol. Chem. 285:5013-5025(2010) Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma.Meissburger B., Ukropec J., Roeder E., Beaton N., Geiger M., Teupser D., Civan B., Langhans W., Nawroth P.P., Gasperikova D., Rudofsky G., Wolfrum C.EMBO Mol. Med. 3:637-651(2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.Solt L.A., Kumar N., Nuhant P., Wang Y., Lauer J.L., Liu J., Istrate M.A., Kamenecka T.M., Roush W.R., Vidovic D., Schuerer S.C., Xu J., Wagoner G., Drew P.D., Griffin P.R., Burris T.P.Nature 472:491-494(2011) Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.Nature 480:552-556(2011) Action of RORs and their ligands in (patho) physiology.Solt L.A., Burris T.P.Trends Endocrinol. Metab. 23:619-627(2012) Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.Jin L., Martynowski D., Zheng S., Wada T., Xie W., Li Y.Mol. Endocrinol. 24:923-929(2010)
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 Research Articles on RORC    1. Our study showed that high CNVs of Rorc and low CNVs of Foxp3 confer risk for BD but not for VKH syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RORC recombinant proteinPathways associated with RORC recombinant protein
 Reference Product  PubMed Publications
 FOXP3 recombinant protein  >137 publications with RORC and FOXP3
 NR1D1 recombinant protein  >5 publications with RORC and NR1D1
 RORB recombinant protein  >5 publications with RORC and RORB
 NR1D2 recombinant protein  >3 publications with RORC and NR1D2
 NPAS2 recombinant protein  >1 publications with RORC and NPAS2
 Products by Pathway  Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
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 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
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 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with RORC recombinant proteinOrgans/Tissues associated with RORC recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >149 publications with RORC and Inflammation
 Disease Models, Animal Antibodies  >55 publications with RORC and Disease Models, Animal
 Nervous System Diseases Antibodies  >45 publications with RORC and Nervous System Diseases
 Necrosis Antibodies  >30 publications with RORC and Necrosis
 Cardiovascular Diseases Antibodies  >24 publications with RORC and Cardiovascular Diseases
 Liver Diseases Antibodies  >12 publications with RORC and Liver Diseases
 Atherosclerosis Antibodies  >9 publications with RORC and Atherosclerosis
 Kidney Diseases Antibodies  >6 publications with RORC and Kidney Diseases
 Liver Neoplasms Antibodies  >5 publications with RORC and Liver Neoplasms
 Fibrosis Antibodies  >4 publications with RORC and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >161 publications with RORC and Thyroid
 Intestine Antibodies  >53 publications with RORC and Intestine
 Thymus Antibodies  >41 publications with RORC and Thymus
 Liver Antibodies  >37 publications with RORC and Liver
 Lymph Node Antibodies  >37 publications with RORC and Lymph Node
 Bone Antibodies  >30 publications with RORC and Bone
 Lung Antibodies  >26 publications with RORC and Lung
 Muscle Antibodies  >14 publications with RORC and Muscle
 Brain Antibodies  >11 publications with RORC and Brain
 Kidney Antibodies  >9 publications with RORC and Kidney
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