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NR4A2 recombinant protein :: Nuclear receptor subfamily 4 group A member 2 (NR4A2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS966218 NR4A2 recombinant protein
Unit / Price
0.05 mg (Yeast)  /  $120 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $120 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $1,020 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,205 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,455 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,520 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,530 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,160 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,185 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,190 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,865 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear receptor subfamily 4 group A member 2 (NR4A2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Nuclear receptor subfamily 4 group A member 2 (NR4A2)

 Product Synonym Names    Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor
 Product Gene Name   

NR4A2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    NR4A2; NOT; NURR1; TINUR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS966218 COA    COA PDF
 Sequence Positions    1-598aa; Full length protein
 Sequence    MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
 OMIM    601828
 3D Structure    ModBase 3D Structure for P43354
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NR4A2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NR4A2 recombinant protein

   This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NCBI/Uniprot data below describe general gene information for NR4A2. It may not necessarily be applicable to this product.
 NCBI GI #    5453822
 NCBI GeneID    4929
 NCBI Accession #    NP_006177.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006186.3 [Other Products]
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 UniProt Primary Accession #    P43354 [Other Products]
 UniProt Secondary Accession #    Q16311; Q53RZ2; Q6NXU0 [Other Products]
 UniProt Related Accession #    P43354 [Other Products]
 Molecular Weight    59,809 Da
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 NCBI Official Full Name    nuclear receptor subfamily 4 group A member 2
 NCBI Official Synonym Full Names    nuclear receptor subfamily 4, group A, member 2
 NCBI Official Symbol    NR4A2 [Similar Products]
 NCBI Official Synonym Symbols   
NOT; RNR1; HZF-3; NURR1; TINUR
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 4 group A member 2; nuclear receptor related 1; T-cell nuclear receptor NOT; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; intermediate-early receptor protein; immediate-early response protein NOT; nur related protein-1, human homolog of; transcriptionally-inducible nuclear receptor; NGFI-B/nur77 beta-type transcription factor homolog; transcriptionally inducible nuclear receptor related 1
 UniProt Protein Name    Nuclear receptor subfamily 4 group A member 2
 UniProt Synonym Protein Names   
Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR4A2 [Similar Products]
 UniProt Synonym Gene Names    NOT; NURR1; TINUR [Similar Products]
 UniProt Entry Name    NR4A2_HUMAN
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 NCBI Summary for NR4A2    This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NR4A2    NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity

Biological Process: positive regulation of catalytic activity; adult locomotory behavior; neuron migration; dopamine biosynthetic process; signal transduction; response to insecticide; neuron maturation; post-embryonic development; regulation of respiratory gaseous exchange; general adaptation syndrome; negative regulation of neuron apoptosis; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; response to inorganic substance; transcription, DNA-dependent; death; response to amphetamine; regulation of dopamine metabolic process; central nervous system projection neuron axonogenesis; habenula development; response to hypoxia; cellular response to extracellular stimulus; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling

Disease: Parkinson Disease, Late-onset
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 Research Articles on NR4A2    1. The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NR4A2 recombinant proteinPathways associated with NR4A2 recombinant protein
 Reference Product  PubMed Publications
 RXRB recombinant protein  >1 publications with NR4A2 and RXRB
 CDKN1C recombinant protein  >1 publications with NR4A2 and CDKN1C
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with NR4A2 recombinant proteinOrgans/Tissues associated with NR4A2 recombinant protein
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >89 publications with NR4A2 and Central Nervous System Diseases
 Parkinsonian Disorders Antibodies  >64 publications with NR4A2 and Parkinsonian Disorders
 Parkinson Disease Antibodies  >57 publications with NR4A2 and Parkinson Disease
 Neoplasms Antibodies  >41 publications with NR4A2 and Neoplasms
 Mental Disorders Antibodies  >37 publications with NR4A2 and Mental Disorders
 Schizophrenia Antibodies  >22 publications with NR4A2 and Schizophrenia
 Inflammation Antibodies  >21 publications with NR4A2 and Inflammation
 Death Antibodies  >20 publications with NR4A2 and Death
 Cardiovascular Diseases Antibodies  >16 publications with NR4A2 and Cardiovascular Diseases
 Carcinoma Antibodies  >13 publications with NR4A2 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >208 publications with NR4A2 and Brain
 Nerve Antibodies  >119 publications with NR4A2 and Nerve
 Thyroid Antibodies  >49 publications with NR4A2 and Thyroid
 Embryonic Tissue Antibodies  >36 publications with NR4A2 and Embryonic Tissue
 Blood Antibodies  >34 publications with NR4A2 and Blood
 Kidney Antibodies  >21 publications with NR4A2 and Kidney
 Muscle Antibodies  >19 publications with NR4A2 and Muscle
 Vascular Antibodies  >17 publications with NR4A2 and Vascular
 Adrenal Gland Antibodies  >15 publications with NR4A2 and Adrenal Gland
 Liver Antibodies  >15 publications with NR4A2 and Liver
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