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NUP98 recombinant protein :: Nucleoporin 98kDa (NUP98) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018370 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $275 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.2 mg  /  $525 +1 FREE 8GB USB
0.5 mg  /  $1,015 +1 FREE 8GB USB
1 mg  /  $1,515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nucleoporin 98kDa (NUP98), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Nucleoporin 98kDa (NUP98)

 Product Gene Name   

NUP98 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Nucleoporin 98kDa (NUP98) (MBS2013788)
Antigen: Nucleoporin 98kDa (NUP98) (MBS2018370)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2018370 Technical Datasheet    Technical Datasheet PDF
 Chromosome Location    Chromosome: 11; NC_000011.9 (3696240..3819022, complement). Location: 11p15.5
 OMIM    601021
 3D Structure    ModBase 3D Structure for P52948
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 Host    E. coli
 Species Reactivity    Homo sapiens (Human)
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 Purity/Purification    > 90%
 Form/Format    100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
 Concentration    Original Concentration: 200 ug/mL (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Prokaryotic expression
 Residues    Gln629~Pro894
 Tags    N-terminal His Tag
 Subcellular Location    Nucleus
 Traits    Freeze-dried powder
 Buffer formulation    100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
    
 Predicted isoelectric point    5.5
 Predicted Molecular Mass    33.5kDa
 Accurate Molecular Mass    34kDa as determined by SDS-PAGE reducing conditions.
 USAGE    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of NUP98 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for NUP98 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB.
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of NUP98 recombinant protein    NUP98 recombinant protein Sequence image
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 SDS-PAGE of NUP98 recombinant protein    NUP98 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for NUP98. It may not necessarily be applicable to this product.
 NCBI GI #    56549643
 NCBI GeneID    4928
 NCBI Accession #    NP_005378.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_005387.5 [Other Products]
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 UniProt Primary Accession #    P52948 [Other Products]
 UniProt Secondary Accession #    Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5 [Other Products]
 UniProt Related Accession #    P52948 [Other Products]
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 NCBI Official Full Name    nuclear pore complex protein Nup98-Nup96 isoform 3
 NCBI Official Synonym Full Names    nucleoporin 98kDa
 NCBI Official Symbol    NUP98 [Similar Products]
 NCBI Official Synonym Symbols   
ADIR2; NUP96; NUP196
[Similar Products]
 NCBI Protein Information    nuclear pore complex protein Nup98-Nup96; GLFG-repeat containing nucleoporin
 UniProt Protein Name    Nuclear pore complex protein Nup98-Nup96
 UniProt Synonym Protein Names   
98 kDa nucleoporin; Nucleoporin Nup98; Nup98Nuclear pore complex protein Nup96; Alternative name(s):; 96 kDa nucleoporin; Nucleoporin Nup96
 UniProt Gene Name    NUP98 [Similar Products]
 UniProt Synonym Gene Names    ADAR2; Nup98; Nup96 [Similar Products]
 UniProt Entry Name    NUP98_HUMAN
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 NCBI Summary for NUP98    Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]
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 UniProt Comments for NUP98    NUP98: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Nucleoporin

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: nucleoplasm; kinetochore; nuclear membrane; nuclear pore; nuclear envelope; cytosol; nuclear inclusion body

Molecular Function: protein binding; structural constituent of nuclear pore; transporter activity; peptide binding

Biological Process: nuclear pore complex assembly; mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; protein import into nucleus, docking; mitotic nuclear envelope disassembly; nucleocytoplasmic transport; pathogenesis; viral infectious cycle; glucose transport; nuclear pore organization and biogenesis; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; DNA replication; transmembrane transport
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 Research Articles on NUP98    1. The repeat domain of Nup98 is substantially more cohesive than repeat domains from other nucleoporins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NUP98 recombinant proteinDiseases associated with NUP98 recombinant protein
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Export Of Viral Ribonucleoproteins From Nucleus Pathway antibodies  Export Of Viral Ribonucleoproteins From Nucleus Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Glucose Transport Pathway antibodies  Glucose Transport Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >180 publications with NUP98 and Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >146 publications with NUP98 and Leukemia, Myeloid, Acute
 Immune System Diseases Antibodies  >21 publications with NUP98 and Immune System Diseases
 Death Antibodies  >8 publications with NUP98 and Death
 Growth Disorders Antibodies  >3 publications with NUP98 and Growth Disorders
 Hemorrhage Antibodies  >2 publications with NUP98 and Hemorrhage
 Atherosclerosis Antibodies  >1 publications with NUP98 and Atherosclerosis
 Breast Neoplasms Antibodies  >1 publications with NUP98 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with NUP98 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with NUP98 and Liver Diseases
Organs/Tissues associated with NUP98 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >71 publications with NUP98 and Bone
 Blood Antibodies  >69 publications with NUP98 and Blood
 Liver Antibodies  >5 publications with NUP98 and Liver
 Lymph Node Antibodies  >4 publications with NUP98 and Lymph Node
 Lymph Antibodies  >4 publications with NUP98 and Lymph
 Kidney Antibodies  >4 publications with NUP98 and Kidney
 Thymus Antibodies  >3 publications with NUP98 and Thymus
 Spleen Antibodies  >3 publications with NUP98 and Spleen
 Lung Antibodies  >3 publications with NUP98 and Lung
 Eye Antibodies  >2 publications with NUP98 and Eye
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