NP_054786.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,505 Da
NCBI Official Full Name
O-acetyl-ADP-ribose deacetylase MACROD1
NCBI Official Synonym Full Names
MACRO domain containing 1
NCBI Official Synonym Symbols
NCBI Protein Information
O-acetyl-ADP-ribose deacetylase MACROD1
UniProt Protein Name
O-acetyl-ADP-ribose deacetylase MACROD1
UniProt Synonym Protein Names
MACRO domain-containing protein 1; Protein LRP16; [Protein ADP-ribosylglutamate] hydrolase
UniProt Synonym Gene Names
UniProt Comments for MACROD1
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Research Articles on MACROD1
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Diseases associated with MACROD1 recombinant protein
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