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OSCAR recombinant protein

Scan QR to view Datasheet Catalog #    MBS204799
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OSCAR, Recombinant Protein

 Also Known As   

OSCAR, 19-286aa, Human, His tag, E Coli

 Product Synonym Names    Osteoclast-associated immunoglobulin-like receptor isoform 1; PIGR3
 Product Gene Name   

OSCAR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSDITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V
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 Purity/Purification    > 85% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of OSCAR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for OSCAR recombinant protein

   Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. OSCAR is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human OSCAR protein, fused to His-tag at N-terminus, was expressed in E.coli.
 Product Categories/Family for OSCAR recombinant protein    Osteoporosis
 Applications Tested/Suitable for OSCAR recombinant protein   

SDS-PAGE

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 SDS-PAGE of OSCAR recombinant protein    OSCAR recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for OSCAR. It may not necessarily be applicable to this product.
 NCBI GI #    537544639
 NCBI GeneID    126014
 NCBI Accession #    NP_996554 [Other Products]
 NCBI GenBank Nucleotide #    NM_206818.2 [Other Products]
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 UniProt Secondary Accession #    Q5GRG5; Q8N763; Q8NHL4; Q8WXQ0; Q8WXQ1; Q8WXQ2; B7WNS2 [Other Products]
 UniProt Related Accession #    Q8IYS5 [Other Products]
 Molecular Weight    31kDa (291aa)
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 NCBI Official Full Name    osteoclast-associated immunoglobulin-like receptor isoform 1
 NCBI Official Synonym Full Names    osteoclast associated, immunoglobulin-like receptor
 NCBI Official Symbol    OSCAR [Similar Products]
 NCBI Official Synonym Symbols   
PIGR3; PIgR-3
[Similar Products]
 NCBI Protein Information    osteoclast-associated immunoglobulin-like receptor; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; poly-Ig receptor 3; polymeric immunoglobulin receptor 3
 UniProt Protein Name    Osteoclast-associated immunoglobulin-like receptor
 UniProt Synonym Protein Names   
Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3
 Protein Family    Osteoclast-associated immunoglobulin-like receptor
 UniProt Gene Name    OSCAR [Similar Products]
 UniProt Synonym Gene Names    Osteoclast-associated receptor; hOSCAR; PIgR-3; PIgR3; Poly-Ig receptor 3 [Similar Products]
 UniProt Entry Name    OSCAR_HUMAN
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 NCBI Summary for OSCAR    Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
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 UniProt Comments for OSCAR    OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: integral to membrane; plasma membrane
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Product References and Citations for OSCAR recombinant protein

   Kim N, Takami M, et al. (2002). J Exp Med. 195(2):201-9.
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 Research Articles on OSCAR    1. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to OSCAR, 19-286aa, Human, His tag, E Coli
 Catalog #  Product Name  Catalog #  Product Name
 MBS8210288  OSCAR siRNA (Mouse)  MBS2511039  Chicken OSCAR (Osteoclast Associated Receptor) ELISA Kit
 MBS2530668  Human OSCAR (Osteoclast Associated Receptor) CLIA Kit  MBS2507970  Human OSCAR (Osteoclast Associated Receptor) ELISA Kit
 MBS9223807  OSCAR Antibody (C-term) Blocking Peptide  MBS2511999  Guinea pig OSCAR (Osteoclast Associated Receptor) ELISA Kit
 MBS2514614  Porcine OSCAR (Osteoclast Associated Receptor) ELISA Kit  MBS2020132  Osteoclast Associated Receptor (OSCAR) ELISA Kit
 MBS204799  OSCAR, 19-286aa, Human, His tag, E Coli  MBS584680  OSCAR, Mouse, mAb 5B8
Products associated with OSCAR recombinant proteinPathways associated with OSCAR recombinant protein
 Reference Product  PubMed Publications
 NFATC1 recombinant protein  >45 publications with OSCAR and NFATC1
 SYK recombinant protein  >5 publications with OSCAR and SYK
 TYROBP recombinant protein  >5 publications with OSCAR and TYROBP
 Products by Pathway  Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with OSCAR recombinant proteinOrgans/Tissues associated with OSCAR recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >126 publications with OSCAR and Death
 Lung Diseases Antibodies  >91 publications with OSCAR and Lung Diseases
 Lung Neoplasms Antibodies  >62 publications with OSCAR and Lung Neoplasms
 Heart Diseases Antibodies  >47 publications with OSCAR and Heart Diseases
 Bone Resorption Antibodies  >45 publications with OSCAR and Bone Resorption
 Necrosis Antibodies  >43 publications with OSCAR and Necrosis
 Inflammation Antibodies  >40 publications with OSCAR and Inflammation
 Kidney Diseases Antibodies  >35 publications with OSCAR and Kidney Diseases
 Liver Neoplasms Antibodies  >32 publications with OSCAR and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >31 publications with OSCAR and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >261 publications with OSCAR and Blood
 Brain Antibodies  >143 publications with OSCAR and Brain
 Lung Antibodies  >101 publications with OSCAR and Lung
 Heart Antibodies  >91 publications with OSCAR and Heart
 Liver Antibodies  >73 publications with OSCAR and Liver
 Skin Antibodies  >64 publications with OSCAR and Skin
 Bone Marrow Antibodies  >49 publications with OSCAR and Bone Marrow
 Eye Antibodies  >45 publications with OSCAR and Eye
 Connective Tissue Antibodies  >26 publications with OSCAR and Connective Tissue
 Uterus Antibodies  >18 publications with OSCAR and Uterus
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