Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow OX40  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Protein S100-A7 (S100A7) ELISA Kit
 • Aryl-phospho-beta-D-glucosi dase BglA (bglA) Recombinant Protein
 • Vasopressin-neurophysin 2-copeptin (Avp) Recombinant Protein
 • HNRNPD - AUF1 Antibody
 • ADRB1 Antibody
 • MMP28 Recombinant Protein
 • Deoxycorticosterone (DOC) ELISA Kit
 • Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) Antibody
 • A Disintegrin and Metalloprotease 18 (ADAM18) ELISA Kit
 • 1-aminocyclopropane-1-carbo xylate synthase-like protein 1 (A... ELISA Kit
 • Grp78 (Bip) (HSPA5) Active Protein
 • Brain Derived Neurotrophic Factor (BDNF) ELISA Kit
 • protein arginine methyltransferase 1 (PRMT1) ELISA Kit
 • Aldehyde Dehydrogenase (ALDH) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

OX40 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539580 OX40 recombinant protein
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OX40, Recombinant Protein

 Also Known As   

OX40 Ligand protein

 Product Synonym Names    OX40 Ligand; OX40L protein; OX Ligand-40; CD252 protein; OX Ligand-40 protein; OX Ligand 40 protein; Gp34 protein; TNFSF4 protein; OX Ligand 40
 Product Gene Name   

OX40 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    152700
 3D Structure    ModBase 3D Structure for P23510
Section Bar
 Host    Human
Section Bar
 Purity/Purification    > 97% pure
 Form/Format    Supplied as a lyophilized powder.
Section Bar
 Protein Type    Recombinant
 Biological Significance    OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL2, IL3, and IFN.
 Bioactivity    Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    Hi-5 cells
Section Bar
 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of OX40 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for OX40 recombinant protein

   Purified recombinant Human OX40 Ligand protein
 Product Categories/Family for OX40 recombinant protein    Immunology
 Applications Tested/Suitable for OX40 recombinant protein   

User optimized

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for OX40. It may not necessarily be applicable to this product.
 NCBI GI #    11275538
 NCBI GeneID    7292
 NCBI Accession #    BAB18304.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P23510 [Other Products]
 UniProt Secondary Accession #    Q5JZA5; Q8IV74; Q9HCN9 [Other Products]
 UniProt Related Accession #    P23510 [Other Products]
 Molecular Weight    15.5-25 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    OX40 ligand, partial
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 4
 NCBI Official Symbol    TNFSF4 [Similar Products]
 NCBI Official Synonym Symbols   
GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 4
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 4
 UniProt Synonym Protein Names   
Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD_antigen: CD252
 UniProt Gene Name    TNFSF4 [Similar Products]
 UniProt Synonym Gene Names    TXGP1; OX40L [Similar Products]
 UniProt Entry Name    TNFL4_HUMAN
Section Bar
 NCBI Summary for OX40    This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Section Bar
 UniProt Comments for OX40    TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.

Protein type: Cytokine; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: extracellular space; cell surface; integral to plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; positive regulation of activated T cell proliferation; signal transduction; defense response to nematode; positive regulation of interleukin-10 production; T cell proliferation; positive regulation of interleukin-4 production; regulation of adaptive immune response; positive regulation of T-helper 2 cell differentiation; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of memory T cell differentiation; cholesterol metabolic process; positive regulation of T-helper 2 type immune response; negative regulation of transcription factor activity; response to virus; positive regulation of immunoglobulin mediated immune response; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response

Disease: Myocardial Infarction, Susceptibility To
Table BarTOPTable Bar
 Research Articles on OX40    1. Report role of TNFSF4 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with OX40 recombinant proteinPathways associated with OX40 recombinant protein
 Reference Product  PubMed Publications
 TNFRSF4 recombinant protein  >193 publications with OX40 and TNFRSF4
 FOXP3 recombinant protein  >29 publications with OX40 and FOXP3
 TNFSF8 recombinant protein  >16 publications with OX40 and TNFSF8
 TNFSF9 recombinant protein  >14 publications with OX40 and TNFSF9
 FOS recombinant protein  >2 publications with OX40 and FOS
 TNFSF15 recombinant protein  >2 publications with OX40 and TNFSF15
 ATM recombinant protein  >2 publications with OX40 and ATM
 CD8A recombinant protein  >1 publications with OX40 and CD8A
 OLR1 recombinant protein  >1 publications with OX40 and OLR1
 HDAC11 recombinant protein  >1 publications with OX40 and HDAC11
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TSLP Signaling Pathway antibodies  TSLP Signaling Pathway Diagram
Diseases associated with OX40 recombinant proteinOrgans/Tissues associated with OX40 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >340 publications with OX40 and Necrosis
 Inflammation Antibodies  >110 publications with OX40 and Inflammation
 Lung Diseases Antibodies  >48 publications with OX40 and Lung Diseases
 Lupus Erythematosus, Systemic Antibodies  >47 publications with OX40 and Lupus Erythematosus, Systemic
 Cardiovascular Diseases Antibodies  >44 publications with OX40 and Cardiovascular Diseases
 Heart Diseases Antibodies  >21 publications with OX40 and Heart Diseases
 Myocardial Infarction Antibodies  >16 publications with OX40 and Myocardial Infarction
 Neoplasms, Experimental Antibodies  >15 publications with OX40 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >10 publications with OX40 and Kidney Diseases
 Fibrosis Antibodies  >9 publications with OX40 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >62 publications with OX40 and Lymph Node
 Lung Antibodies  >49 publications with OX40 and Lung
 Skin Antibodies  >36 publications with OX40 and Skin
 Bone Marrow Antibodies  >24 publications with OX40 and Bone Marrow
 Mixed Antibodies  >16 publications with OX40 and Mixed
 Eye Antibodies  >11 publications with OX40 and Eye
 Thymus Antibodies  >11 publications with OX40 and Thymus
 Brain Antibodies  >11 publications with OX40 and Brain
 Liver Antibodies  >7 publications with OX40 and Liver
 Larynx Antibodies  >1 publications with OX40 and Larynx
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions