NP_523458.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
odorant receptor 23a
NCBI Official Synonym Full Names
Odorant receptor 23a
NCBI Official Synonym Symbols
23a; 23A.1; AN5; CG9880; DmelCG9880; DOR23A.1; dor64; Dor64; DOR64; Or23A.1; Or64 [Similar Products]
NCBI Protein Information
CG9880 gene product from transcript CG9880-RA; CG9880-PA; Or23a-PA; odorant receptor 23a; odorant receptor 64; olfactory receptor 23A.1
UniProt Protein Name
Odorant receptor 23a
UniProt Synonym Gene Names
UniProt Entry Name
OR23A_DROME
UniProt Comments for Or23a
Function: Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide
By similarity.
Subunit structure: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Expressed in 10-40 sensory cells in the third antenna segment and in the maxillary palp. Ref.1 Ref.2 Ref.5
Miscellaneous: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Sequence similarities: Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification]
Research Articles on Or23a
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