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OSM recombinant protein :: Oncostatin M Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650717 OSM recombinant protein
Unit / Price
0.002 mg  /  $255 +1 FREE 8GB USB
0.005 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Oncostatin M (OSM), Recombinant Protein

 Also Known As   

Oncostatin M, Recombinant, Human (OSM) (Human 293 Cells)

 Product Gene Name   

OSM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 22; NC_000022.10 (30658818..30662840, complement). Location: 22q12.2
 OMIM    165095
 3D Structure    ModBase 3D Structure for P13725
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 Host    Human 293 cells
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 Purity/Purification    Highly Purified
95% as determined by SDS-PAGE and HPLC.
 Form/Format    Supplied as a lyophilized powder from 20mM Tris, pH 7.4, 150mM NaCl. Reconstitute with sterile dH2O, 0.1% endotoxin-free recombinant HSA.
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 Specific Activity    ~0.5ng/ml ED50
 Endotoxin Level    1EU/ug (LAL)
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O, 0.1% endotoxin-free recombinant HSA. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at 4 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of OSM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for OSM recombinant protein    Growth Factors, Cytokines; Growth Factors-Oncostatin M
NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.
 NCBI GI #    10092621
 NCBI GeneID    5008
 NCBI Accession #    NP_065391.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020530.4 [Other Products]
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 UniProt Primary Accession #    P13725 [Other Products]
 UniProt Secondary Accession #    Q6FHP8; Q9UCP6 [Other Products]
 UniProt Related Accession #    P13725 [Other Products]
 Molecular Weight    30-31kD [Similar Products]
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 NCBI Official Full Name    oncostatin-M preproprotein
 NCBI Official Synonym Full Names    oncostatin M
 NCBI Official Symbol    OSM [Similar Products]
 NCBI Official Synonym Symbols   
MGC20461
[Similar Products]
 NCBI Protein Information    oncostatin-M; OTTHUMP00000198700
 UniProt Protein Name    Oncostatin-M
 Protein Family    Oncostatin
 UniProt Gene Name    OSM [Similar Products]
 UniProt Entry Name    ONCM_HUMAN
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 NCBI Summary for OSM    Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq]
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 UniProt Comments for OSM    Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration

By similarity. Ref.8 Ref.12

Subcellular location: Secreted.

Post-translational modification: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.

Sequence similarities: Belongs to the LIF/OSM family.
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 Research Articles on OSM    1. a cytokine-triggered regulatory network for PCSK9 expression that is linked to JAKs and the ERK signaling pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with OSM recombinant proteinPathways associated with OSM recombinant protein
 Reference Product  PubMed Publications
 LIFR recombinant protein  >377 publications with OSM and LIFR
 IL6ST recombinant protein  >176 publications with OSM and IL6ST
 OSMR recombinant protein  >50 publications with OSM and OSMR
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with OSM recombinant proteinOrgans/Tissues associated with OSM recombinant protein
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >633 publications with OSM and Leukemia
 Neoplasms Antibodies  >298 publications with OSM and Neoplasms
 Inflammation Antibodies  >168 publications with OSM and Inflammation
 Immune System Diseases Antibodies  >106 publications with OSM and Immune System Diseases
 Cardiovascular Diseases Antibodies  >72 publications with OSM and Cardiovascular Diseases
 Neuroectodermal Tumors Antibodies  >68 publications with OSM and Neuroectodermal Tumors
 Skin Diseases Antibodies  >66 publications with OSM and Skin Diseases
 Melanoma Antibodies  >58 publications with OSM and Melanoma
 Vascular Diseases Antibodies  >58 publications with OSM and Vascular Diseases
 Liver Diseases Antibodies  >56 publications with OSM and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >402 publications with OSM and Blood
 Brain Antibodies  >127 publications with OSM and Brain
 Kidney Antibodies  >113 publications with OSM and Kidney
 Lung Antibodies  >80 publications with OSM and Lung
 Intestine Antibodies  >19 publications with OSM and Intestine
 Thymus Antibodies  >17 publications with OSM and Thymus
 Ovary Antibodies  >12 publications with OSM and Ovary
 Uncharacterized Tissue Antibodies  >2 publications with OSM and Uncharacterized Tissue
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