Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow OPTN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Phospho-2-dehydro-3-deoxyhe ptonate aldolase, tyrosine-inhibi... Recombinant Protein
 • Band 3 anion transport protein (SLC4A1) ELISA Kit
 • CRP free serum Plasma
 • Mouse Anti-Human IgG4 (gamma 4 chain specific) Secondary Antibody
 • Protein cereblon (Crbn) Recombinant Protein
 • Hyaluronan Synthase 3 (HAS3) ELISA Kit
 • collagen, type XVII, alpha 1 (COL17A1) ELISA Kit
 • ADI1 Antibody
 • Nicotinic acetylcholine receptor (N-AChR) ELISA Kit
 • Ras Homolog Enriched in Brain (RHEB) Recombinant Protein
 • OCT4 - POU5F1 Peptide
 • Fox3 Antibody
 • alpha-Glucosidase (alpha-GluD) Enzyme
 • Plasmodium vivax circumsporozoite protein (CSP) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

OPTN recombinant protein :: Optineurin (OPTN) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1399122
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $135 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $255 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $420 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $665 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $775 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,040 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,450 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,605 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,805 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,000 +2 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $2,100 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,600 +3 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,855 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,560 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Optineurin (OPTN), Recombinant Protein

 Also Known As   

Recombinant Human Optineurin (OPTN)

 Product Synonym Names    Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein;
 Product Gene Name   

OPTN recombinant protein

[Similar Products]
 Product Synonym Gene Name    OPTN; FIP2; GLC1E; HIP7; HYPL; NRP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS1399122 COA    COA PDF
 Sequence Positions    1-577. Full length.
 Sequence    MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE ALNLQVTSLF KELQEAHTKL SKAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII
 OMIM    613435
 3D Structure    ModBase 3D Structure for Q96CV9
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Homo sapiens (Human)
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of OPTN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
Section Bar
 SDS-PAGE of OPTN recombinant protein    Recombinant Human Optineurin(OPTN)
His-tagged
Yeast derived
OPTN recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for OPTN. It may not necessarily be applicable to this product.
 NCBI GI #    56549107
 NCBI GeneID    10133
 NCBI Accession #    NP_001008212.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008211.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q96CV9 [Other Products]
 UniProt Secondary Accession #    Q5T672; Q5T673; Q5T674; Q5T675; Q7LDL9; Q8N562; Q9UET9; Q9UEV4; B3KP00; D3DRS4; D3DRS8 [Other Products]
 UniProt Related Accession #    Q96CV9 [Other Products]
 Molecular Weight    59,559 Da
Table BarTOPTable Bar
 NCBI Official Full Name    optineurin
 NCBI Official Synonym Full Names    optineurin
 NCBI Official Symbol    OPTN [Similar Products]
 NCBI Official Synonym Symbols   
NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP
[Similar Products]
 NCBI Protein Information    optineurin; FIP-2; HIP-7; nemo-related protein; huntingtin yeast partner L; E3-14.7K-interacting protein; Huntingtin interacting protein L; huntingtin-interacting protein 7; huntingtin-interacting protein L; optic neuropathy-inducing protein; transcrption factor IIIA-interacting protein; transcription factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
 UniProt Protein Name    Optineurin
 UniProt Synonym Protein Names   
E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP
 Protein Family    Optineurin
 UniProt Gene Name    OPTN [Similar Products]
 UniProt Synonym Gene Names    FIP2; GLC1E; HIP7; HYPL; NRP; HIP-7; TFIIIA-IntP [Similar Products]
 UniProt Entry Name    OPTN_HUMAN
Section Bar
 NCBI Summary for OPTN    This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for OPTN    optineurin: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). Defects in OPTN are the cause of amyotrophic lateral sclerosis type 12 (ALS12). It is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; recycling endosome; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasm; autophagic vacuole; trans-Golgi network; cytosol; nucleus

Molecular Function: protein C-terminus binding; protein binding; polyubiquitin binding; Rab GTPase binding

Biological Process: cell death; macroautophagy; Golgi to plasma membrane protein transport; negative regulation of receptor recycling; mitotic cell cycle; negative regulation of I-kappaB kinase/NF-kappaB cascade; protein targeting to Golgi; defense response to Gram-negative bacterium; signal transduction; regulation of I-kappaB kinase/NF-kappaB cascade; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis

Disease: Glaucoma, Normal Tension, Susceptibility To; Glaucoma, Primary Open Angle; Amyotrophic Lateral Sclerosis 12
Table BarTOPTable Bar
 Research Articles on OPTN    1. HACE1-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with OPTN recombinant proteinPathways associated with OPTN recombinant protein
 Reference Product  PubMed Publications
 RAB8A recombinant protein  >2 publications with OPTN and RAB8A
 HTT recombinant protein  >2 publications with OPTN and HTT
 FOS recombinant protein  >1 publications with OPTN and FOS
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Regulation Of PLK1 Activity At G2/M Transition Pathway antibodies  Regulation Of PLK1 Activity At G2/M Transition Pathway Diagram
Diseases associated with OPTN recombinant proteinOrgans/Tissues associated with OPTN recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >49 publications with OPTN and Liver Diseases
 Kidney Diseases Antibodies  >38 publications with OPTN and Kidney Diseases
 Cardiovascular Diseases Antibodies  >22 publications with OPTN and Cardiovascular Diseases
 Necrosis Antibodies  >19 publications with OPTN and Necrosis
 Immune System Diseases Antibodies  >18 publications with OPTN and Immune System Diseases
 Carcinoma, Hepatocellular Antibodies  >16 publications with OPTN and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >14 publications with OPTN and Heart Diseases
 Liver Neoplasms Antibodies  >10 publications with OPTN and Liver Neoplasms
 Inflammation Antibodies  >10 publications with OPTN and Inflammation
 Atrophy Antibodies  >10 publications with OPTN and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >111 publications with OPTN and Kidney
 Eye Antibodies  >94 publications with OPTN and Eye
 Liver Antibodies  >79 publications with OPTN and Liver
 Blood Antibodies  >53 publications with OPTN and Blood
 Heart Antibodies  >41 publications with OPTN and Heart
 Nerve Antibodies  >40 publications with OPTN and Nerve
 Lung Antibodies  >33 publications with OPTN and Lung
 Pancreas Antibodies  >27 publications with OPTN and Pancreas
 Brain Antibodies  >22 publications with OPTN and Brain
 Intestine Antibodies  >14 publications with OPTN and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions