NP_659549.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,755 Da
NCBI Official Full Name
optineurin
NCBI Official Synonym Full Names
optineurin
NCBI Official Synonym Symbols
NCBI Protein Information
optineurin
UniProt Protein Name
Optineurin
UniProt Synonym Protein Names
FIP-2-like protein
NCBI Summary for Optn
an injury induced protein; human homolog may be linked to glaucoma [RGD, Feb 2006]
UniProt Comments for Optn
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
Research Articles on Optn
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Products associated with Optn recombinant protein
Pathways associated with Optn recombinant protein
Diseases associated with Optn recombinant protein
Organs/Tissues associated with Optn recombinant protein
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