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Otc recombinant protein :: Ornithine carbamoyltransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960037
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $730 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $850 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $980 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,075 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,145 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,235 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,250 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,295 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,525 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,805 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,870 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,970 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,400 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ornithine carbamoyltransferase (Otc), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Ornithine carbamoyltransferase, mitochondrial

 Product Synonym Names    Ornithine transcarbamylase; OTCase
 Product Gene Name   

Otc recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS960037 COA    COA PDF
 Sequence Positions    33-354aa; Full Length
 Sequence    SQVQLKGRDL LTLKNFTGEE IQYMLWLSAD LKFRIKQKGE YLPLLQGKSL GMIFEKRSTR TRLSTETGFA LLGGHPSFLT TQDIHLGVNE SLTDTARVLS SMTDAVLARV YKQSDLDTLA KEASIPIVNG LSDLYHPIQI LADYLTLQEH YGSLKGLTLS WIGDGNNILH SIMMSAAKFG MHLQAATPKG YEPDPNIVKL AEQYAKENGT KLSMTNDPLE AARGGNVLIT DTWISMGQED EKKKRLQAFQ GYQVTMKTAK VAASDWTFLH CLPRKPEEVD DEVFYSPRSL VFPEAENRKW TIMAVMVSLL TDYSPVLQKP KF
 3D Structure    ModBase 3D Structure for P11725
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Otc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 SDS-Page of Otc recombinant protein    Otc recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Otc. It may not necessarily be applicable to this product.
 NCBI GI #    6679184
 NCBI GeneID    18416
 NCBI Accession #    NP_032795.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008769.4 [Other Products]
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 UniProt Primary Accession #    P11725 [Other Products]
 UniProt Related Accession #    P11725 [Other Products]
 Molecular Weight    52.1kD
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 NCBI Official Full Name    ornithine carbamoyltransferase, mitochondrial
 NCBI Official Synonym Full Names    ornithine transcarbamylase
 NCBI Official Symbol    Otc [Similar Products]
 NCBI Official Synonym Symbols   
Sf; spf; AI265390
[Similar Products]
 NCBI Protein Information    ornithine carbamoyltransferase, mitochondrial
 UniProt Protein Name    Ornithine carbamoyltransferase, mitochondrial
 UniProt Synonym Protein Names   
Ornithine transcarbamylase; OTCase
 Protein Family    Ornithine carbamoyltransferase
 UniProt Gene Name    Otc [Similar Products]
 UniProt Synonym Gene Names    OTCase [Similar Products]
 UniProt Entry Name    OTC_MOUSE
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 UniProt Comments for Otc    OTC: Defects in OTC are the cause of ornithine carbamoyltransferase deficiency (OTCD). OTCD is an X- linked disorder of the urea cycle which causes a form of hyperammonemia. Mutations with no residual enzyme activity are always expressed in hemizygote males by a very severe neonatal hyperammonemic coma that generally proves to be fatal. Heterozygous females are either asymptomatic or express orotic aciduria spontaneously or after protein intake. The disorder is treatable with supplemental dietary arginine and low protein diet. The arbitrary classification of patients into the 'neonatal' group (clinical hyperammonemia in the first few days of life) and 'late' onset (clinical presentation after the neonatal period) has been used to differentiate severe from mild forms. Belongs to the ATCase/OTCase family.

Protein type: Mitochondrial; EC 2.1.3.3; Amino Acid Metabolism - arginine and proline; Transferase

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion

Molecular Function: amino acid binding; carboxyl- or carbamoyltransferase activity; ornithine carbamoyltransferase activity; phosphate binding; phospholipid binding; transferase activity

Biological Process: amino acid biosynthetic process; amino acid metabolic process; anion homeostasis; arginine biosynthetic process; arginine biosynthetic process via ornithine; citrulline biosynthetic process; ornithine catabolic process; ornithine metabolic process; urea cycle
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Product References and Citations for Otc recombinant protein

   The molecular basis of the sparse fur mouse mutation.Veres G., Gibbs R.A., Scherer S.E., Caskey C.T.Science 237:415-417(1987) The genetic structure of mouse ornithine transcarbamylase.Scherer S.E., Veres G., Caskey C.T.Nucleic Acids Res. 16:1593-1601(1988) The 5' flanking region of the ornithine transcarbamylase gene contains DNA sequences regulating tissue-specific expression.Veres G., Craigen W.J., Caskey C.T.J. Biol. Chem. 261:7588-7591(1986) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013) Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013)
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 Research Articles on Otc    1. Serum OCT seemed to reflect tumor necrosis factor-alpha-mediated hepatic damage in diabetic obese mice and could be useful in the application for non-alcoholic fatty liver disease with features of metabolic syndrome, such as obesity and diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Otc recombinant proteinPathways associated with Otc recombinant protein
 Reference Product  PubMed Publications
 Cps1 recombinant protein  >14 publications with Otc and Cps1
 Nags recombinant protein  >7 publications with Otc and Nags
 Arg1 recombinant protein  >5 publications with Otc and Arg1
 Ass1 recombinant protein  >4 publications with Otc and Ass1
 Oat recombinant protein  >3 publications with Otc and Oat
 Cad recombinant protein  >2 publications with Otc and Cad
 Arg2 recombinant protein  >2 publications with Otc and Arg2
 Acy1 recombinant protein  >1 publications with Otc and Acy1
 Products by Pathway  Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Urea Cycle Pathway antibodies  Urea Cycle Pathway Diagram
Diseases associated with Otc recombinant proteinOrgans/Tissues associated with Otc recombinant protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >394 publications with Otc and Brain Diseases
 ORNITHINE TRANSCARBAMYLASE DEFICIENCY, HYPERAMMONEMIA DUE TO Antibodies  >335 publications with Otc and ORNITHINE TRANSCARBAMYLASE DEFICIENCY, HYPERAMMONEMIA DUE TO
 Ornithine Carbamoyltransferase Deficiency Disease Antibodies  >312 publications with Otc and Ornithine Carbamoyltransferase Deficiency Disease
 Hyperammonemia Antibodies  >165 publications with Otc and Hyperammonemia
 Liver Diseases Antibodies  >91 publications with Otc and Liver Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >65 publications with Otc and Drug-Related Side Effects and Adverse Reactions
 Disease Models, Animal Antibodies  >57 publications with Otc and Disease Models, Animal
 Inflammation Antibodies  >52 publications with Otc and Inflammation
 Coma Antibodies  >49 publications with Otc and Coma
 Heart Diseases Antibodies  >47 publications with Otc and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >411 publications with Otc and Liver
 Muscle Antibodies  >116 publications with Otc and Muscle
 Intestine Antibodies  >41 publications with Otc and Intestine
 Embryonic Tissue Antibodies  >12 publications with Otc and Embryonic Tissue
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