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SPP1 recombinant protein :: Osteopontin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265469 SPP1 recombinant protein
Unit / Price
0.05 mg  /  $195 +1 FREE 8GB USB
0.2 mg  /  $465 +1 FREE 8GB USB
0.5 mg  /  $815 +1 FREE 8GB USB
1 mg  /  $1,290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Osteopontin (SPP1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant human Osteopontin

 Product Gene Name   

SPP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    IPVKQADSGS SEEKQLYNKY PDAVATWLNP DPSQKQNLLA PQNAVSSEET NDFKQETLPS KSNESHDHMD DMDDEDDDDH VDSQDSIDSN DSDDVDDTDD SHQSDESHHS DESDELVTDF PTDLPATEVF TPVVPTVDTY DGRGDSVVYG LRSKSKKFRR PDIQYPDATD EDITSHMESE ELNGAYKAIP VAQDLNAPSD WDSRGKDSYE TSQLDDQSAE THSHKQSRLY KRKANDESNE HSDVIDSQEL SKVSREFHSH EFHSHEDMLV VDPKSKEEDK HLKF
 Chromosome Location    Chromosome: 4; NC_000004.11 (88896802..88904563). Location: 4q22.1
 OMIM    166490
 3D Structure    ModBase 3D Structure for P10451
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 Host    E Coli
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 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SPP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SPP1. It may not necessarily be applicable to this product.
 NCBI GI #    189405
 NCBI GeneID    6696
 NCBI Accession #    AAA59974.1 [Other Products]
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 UniProt Primary Accession #    P10451 [Other Products]
 UniProt Secondary Accession #    Q15681; Q15682; Q15683; Q4W597; Q567T5; Q8NBK2; Q96IZ1; B2RDA1 [Other Products]
 UniProt Related Accession #    P10451 [Other Products]
 Molecular Weight    35,423 Da [Similar Products]
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 NCBI Official Full Name    osteopontin
 NCBI Official Synonym Full Names    secreted phosphoprotein 1
 NCBI Official Symbol    SPP1 [Similar Products]
 NCBI Official Synonym Symbols   
OPN; BNSP; BSPI; ETA-1
[Similar Products]
 NCBI Protein Information    osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
 UniProt Protein Name    Osteopontin
 UniProt Synonym Protein Names   
Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
 Protein Family    Osteopontin
 UniProt Gene Name    SPP1 [Similar Products]
 UniProt Synonym Gene Names    BNSP; OPN; SPP-1 [Similar Products]
 UniProt Entry Name    OSTP_HUMAN
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 NCBI Summary for SPP1    The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for SPP1    osteopontin: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: extracellular space; cell projection; perinuclear region of cytoplasm; apical part of cell; extracellular region

Molecular Function: protein binding; extracellular matrix binding; cytokine activity

Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; decidualization; osteoblast differentiation; extracellular matrix disassembly; response to vitamin D; biomineral formation; response to steroid hormone stimulus; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; cell adhesion; inflammatory response; embryo implantation
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 Research Articles on SPP1    1. The N-terminal fragment of osteopontin, rather than full-length OPN or C-terminal OPN, is associated with carotid plaque inflammation in hypertensive patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPP1 recombinant proteinPathways associated with SPP1 recombinant protein
 Reference Product  PubMed Publications
 CD44 recombinant protein  >112 publications with SPP1 and CD44
 RUNX2 recombinant protein  >95 publications with SPP1 and RUNX2
 BMP2 recombinant protein  >63 publications with SPP1 and BMP2
 PTH recombinant protein  >38 publications with SPP1 and PTH
 FN1 recombinant protein  >10 publications with SPP1 and FN1
 ITGA5 recombinant protein  >3 publications with SPP1 and ITGA5
 ITGB1 recombinant protein  >2 publications with SPP1 and ITGB1
 ITGAV recombinant protein  >2 publications with SPP1 and ITGAV
 ITGB3 recombinant protein  >1 publications with SPP1 and ITGB3
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with SPP1 recombinant proteinOrgans/Tissues associated with SPP1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >481 publications with SPP1 and Neoplasms
 Cardiovascular Diseases Antibodies  >241 publications with SPP1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >210 publications with SPP1 and Kidney Diseases
 Inflammation Antibodies  >204 publications with SPP1 and Inflammation
 Fibrosis Antibodies  >136 publications with SPP1 and Fibrosis
 Necrosis Antibodies  >110 publications with SPP1 and Necrosis
 Calcinosis Antibodies  >104 publications with SPP1 and Calcinosis
 Adenocarcinoma Antibodies  >98 publications with SPP1 and Adenocarcinoma
 Heart Diseases Antibodies  >92 publications with SPP1 and Heart Diseases
 Breast Neoplasms Antibodies  >79 publications with SPP1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >998 publications with SPP1 and Bone
 Blood Antibodies  >488 publications with SPP1 and Blood
 Kidney Antibodies  >347 publications with SPP1 and Kidney
 Connective Tissue Antibodies  >310 publications with SPP1 and Connective Tissue
 Vascular Antibodies  >309 publications with SPP1 and Vascular
 Muscle Antibodies  >251 publications with SPP1 and Muscle
 Bone Marrow Antibodies  >173 publications with SPP1 and Bone Marrow
 Mouth Antibodies  >159 publications with SPP1 and Mouth
 Heart Antibodies  >118 publications with SPP1 and Heart
 Liver Antibodies  >113 publications with SPP1 and Liver
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