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TNFRSF11B recombinant protein :: Osteoprotegerin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS637329 TNFRSF11B recombinant protein
Unit / Price
0.01 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Osteoprotegerin (TNFRSF11B), Recombinant Protein

★Popular Item★
 Also Known As   

Osteoprotegerin, Recombinant, Human (OPG, MGC29565, Osteoclastogenesis Inhibitory Factor, OCIF, TR1, Tumor Necrosis Factor Receptor Superfamily Member 11B, TNFRSF11B)

 Product Gene Name   

TNFRSF11B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (119935796..119964383, complement). Location: 8q24
 OMIM    239000
 3D Structure    ModBase 3D Structure for O00300
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 Purity/Purification    Highly Purified
>98% (SDS-PAGE and HPLC).
 Form/Format    Supplied as a lyophilized powder. Reconstitute in 5mM Tris, pH 7.5 to a concentration of 0.1-1mg/ml.
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 Biological Activity    Determined by its ability to neutralize the stimulation of U937 cells treated with 10ng/ml of sRANKL.
 Source    E.coli
  Endotoxin    <0.1ng/ug.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with Tris. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
 Other Notes    Small volumes of TNFRSF11B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TNFRSF11B recombinant protein

   Human OPG (Osteoprotegerin), also known as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number. Recombinant human OPG is a 20kD protein, comprising of 174 amino acid residues.
 Product Categories/Family for TNFRSF11B recombinant protein    Molecular Biology; MB-Osteoprotegerin
NCBI/Uniprot data below describe general gene information for TNFRSF11B. It may not necessarily be applicable to this product.
 NCBI GI #    2072185
 NCBI GeneID    4982
 NCBI Accession #    AAB53709.1 [Other Products]
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 UniProt Primary Accession #    O00300 [Other Products]
 UniProt Secondary Accession #    O60236; Q53FX6; Q9UHP4; B2R9A8 [Other Products]
 UniProt Related Accession #    O00300 [Other Products]
 Molecular Weight    46,026 Da [Similar Products]
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 NCBI Official Full Name    osteoprotegerin
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 11b
 NCBI Official Symbol    TNFRSF11B [Similar Products]
 NCBI Official Synonym Symbols   
OPG; TR1; OCIF
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 11B
 UniProt Synonym Protein Names   
Osteoclastogenesis inhibitory factor; Osteoprotegerin
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF11B [Similar Products]
 UniProt Synonym Gene Names    OCIF; OPG [Similar Products]
 UniProt Entry Name    TR11B_HUMAN
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 NCBI Summary for TNFRSF11B    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFRSF11B    TNFRSF11B: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: cytokine activity; receptor activity

Biological Process: response to drug; response to magnesium ion; extracellular matrix organization and biogenesis; apoptosis; negative regulation of odontogenesis of dentine-containing teeth; response to estrogen stimulus; response to arsenic; signal transduction; negative regulation of bone resorption; skeletal development; response to nutrient

Disease: Paget Disease, Juvenile
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 Research Articles on TNFRSF11B    1. Maxillary sinus augmentation procedures through equine-derived biomaterial or calvaria autologous bone: immunohistochemical evaluation of OPG/RANKL in humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF11B recombinant proteinPathways associated with TNFRSF11B recombinant protein
 Reference Product  PubMed Publications
 TNFSF11 recombinant protein  >2058 publications with TNFRSF11B and TNFSF11
 TNFSF10 recombinant protein  >163 publications with TNFRSF11B and TNFSF10
 TGFB1 recombinant protein  >63 publications with TNFRSF11B and TGFB1
 IL17A recombinant protein  >31 publications with TNFRSF11B and IL17A
 PPARG recombinant protein  >25 publications with TNFRSF11B and PPARG
 IL18 recombinant protein  >13 publications with TNFRSF11B and IL18
 IGF1R recombinant protein  >6 publications with TNFRSF11B and IGF1R
 PRL recombinant protein  >5 publications with TNFRSF11B and PRL
 BMPR2 recombinant protein  >4 publications with TNFRSF11B and BMPR2
 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 RANKL/RANK Signaling Pathway antibodies  RANKL/RANK Signaling Pathway Diagram
Diseases associated with TNFRSF11B recombinant proteinOrgans/Tissues associated with TNFRSF11B recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1691 publications with TNFRSF11B and Necrosis
 Bone Resorption Antibodies  >1580 publications with TNFRSF11B and Bone Resorption
 Osteoporosis Antibodies  >800 publications with TNFRSF11B and Osteoporosis
 Neoplasms Antibodies  >535 publications with TNFRSF11B and Neoplasms
 Cardiovascular Diseases Antibodies  >526 publications with TNFRSF11B and Cardiovascular Diseases
 Inflammation Antibodies  >427 publications with TNFRSF11B and Inflammation
 Osteolysis Antibodies  >233 publications with TNFRSF11B and Osteolysis
 Kidney Diseases Antibodies  >181 publications with TNFRSF11B and Kidney Diseases
 Nervous System Diseases Antibodies  >111 publications with TNFRSF11B and Nervous System Diseases
 Breast Neoplasms Antibodies  >104 publications with TNFRSF11B and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3338 publications with TNFRSF11B and Bone
 Connective Tissue Antibodies  >648 publications with TNFRSF11B and Connective Tissue
 Bone Marrow Antibodies  >618 publications with TNFRSF11B and Bone Marrow
 Vascular Antibodies  >532 publications with TNFRSF11B and Vascular
 Mouth Antibodies  >253 publications with TNFRSF11B and Mouth
 Kidney Antibodies  >188 publications with TNFRSF11B and Kidney
 Muscle Antibodies  >146 publications with TNFRSF11B and Muscle
 Heart Antibodies  >125 publications with TNFRSF11B and Heart
 Liver Antibodies  >68 publications with TNFRSF11B and Liver
 Brain Antibodies  >60 publications with TNFRSF11B and Brain
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