NP_579840.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
41,890 Da
NCBI Official Full Name
oxidized low-density lipoprotein receptor 1
NCBI Official Synonym Full Names
oxidized low density lipoprotein (lectin-like) receptor 1
NCBI Protein Information
oxidized low-density lipoprotein receptor 1
UniProt Protein Name
Oxidized low-density lipoprotein receptor 1
UniProt Synonym Protein Names
Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1
UniProt Synonym Gene Names
Lox1; Oldlr1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1 [Similar Products]
UniProt Entry Name
OLR1_RAT
NCBI Summary for Olr1
receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006]
UniProt Comments for Olr1
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Research Articles on Olr1
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Pathways associated with Olr1 recombinant protein
Diseases associated with Olr1 recombinant protein
Organs/Tissues associated with Olr1 recombinant protein
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