NP_002549.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,980 Da
NCBI Official Full Name
P2X purinoceptor 1
NCBI Official Synonym Full Names
purinergic receptor P2X 1
NCBI Official Synonym Symbols
NCBI Protein Information
P2X purinoceptor 1
UniProt Protein Name
P2X purinoceptor 1
UniProt Synonym Protein Names
ATP receptor; Purinergic receptor
UniProt Synonym Gene Names
NCBI Summary for P2RX1
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
UniProt Comments for P2RX1
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death ().
Research Articles on P2RX1
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Products associated with P2RX1 recombinant protein
Pathways associated with P2RX1 recombinant protein
Diseases associated with P2RX1 recombinant protein
Organs/Tissues associated with P2RX1 recombinant protein
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