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PA2G4 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203652
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PA2G4, Recombinant Protein

 Also Known As   

PA2G4, 1-394aa, Human, His tag, E Coli

 Product Synonym Names    Proliferation-associated protein 2G4; EBP1; HG4-1; p38-2G4; Proliferation-associated protein 2G4 38kDa; AA672939; Cell cycle protein p38 2G4 homolog; ErbB-3 binding protein 1; ErbB3 binding protein 1 ErbB3-binding protein Ebp1; hG4 1; IRES-specific cellular trans-acting factor 45 kDa; MGC81621; MGC94070; Mpp1.M545; p38 2G4; PA2G4; Plfap; Proliferation associated 2G4; zgc:86732; Proliferation associated 2G4; 38-KD; Proliferation-associated 2G4; 38kDa; Proliferation-associated 2G4; a; Proliferation-associated protein 1 Protein p38-2G4; si:dz150i12.2; wu:fb19b11; wu:ft56d05
 Product Gene Name   

PA2G4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGDLEHHHH HH
 OMIM    U59435 mRNA
 3D Structure    ModBase 3D Structure for Q9UQ80
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PA2G4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PA2G4 recombinant protein

   PA2G4, also known as EBP1 (ErbB-3-binding protein 1), is a member of the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. It is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. In addition, this protein interacts with ErbB-3 and may function as a modulator of the ErbB-3 mediated signal transduction pathway by regulating the effects of Neuregulin-1. Recombinant human PA2G4 protein, fused to His-tag at C-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PA2G4 recombinant protein    Transcription & Translation
 Applications Tested/Suitable for PA2G4 recombinant protein   

SDS-PAGE

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 SDS-Page of PA2G4 recombinant protein    PA2G4 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PA2G4. It may not necessarily be applicable to this product.
 NCBI GI #    124494254
 NCBI GeneID    5036
 NCBI Accession #    NP_006182 [Other Products]
 NCBI GenBank Nucleotide #    NM_006191.2 [Other Products]
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 UniProt Primary Accession #    Q9UQ80 [Other Products]
 UniProt Secondary Accession #    O43846; Q9UM59 [Other Products]
 UniProt Related Accession #    Q9UQ80 [Other Products]
 Molecular Weight    44.8kDa (402aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    proliferation-associated protein 2G4
 NCBI Official Synonym Full Names    proliferation-associated 2G4
 NCBI Official Symbol    PA2G4 [Similar Products]
 NCBI Official Synonym Symbols   
EBP1; HG4-1; p38-2G4
[Similar Products]
 NCBI Protein Information    proliferation-associated protein 2G4
 UniProt Protein Name    Proliferation-associated protein 2G4
 UniProt Synonym Protein Names   
Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1
 Protein Family    Proliferation-associated protein
 UniProt Gene Name    PA2G4 [Similar Products]
 UniProt Synonym Gene Names    EBP1; hG4-1 [Similar Products]
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 NCBI Summary for PA2G4    This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PA2G4    May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation ().
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Product References and Citations for PA2G4 recombinant protein

   Lamartine J. et al. (1997) Cytogenet Cell Genet. 78 (1):31-5; Yoo JY. et al. (2000) Br J Cancer. 82 (3):683-90.;
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 Research Articles on PA2G4    1. The results demonstrate an important role of Ebp1 in promoting cell proliferation in Acute Myelogenous Leukemic Cells through the regulation of both rRNA synthesis and Proliferating Cell Nuclear Antigen expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PA2G4 recombinant proteinDiseases associated with PA2G4 recombinant protein
 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Disease Name  Pubmed Publications
 Disease Progression Antibodies  >10 publications with PA2G4 and Disease Progression
 Adenocarcinoma Antibodies  >8 publications with PA2G4 and Adenocarcinoma
 Neoplasm Invasiveness Antibodies  >7 publications with PA2G4 and Neoplasm Invasiveness
 Neoplasms, Experimental Antibodies  >4 publications with PA2G4 and Neoplasms, Experimental
 Inflammation Antibodies  >4 publications with PA2G4 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with PA2G4 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with PA2G4 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with PA2G4 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with PA2G4 and Carcinoma, Hepatocellular
 Lung Diseases Antibodies  >3 publications with PA2G4 and Lung Diseases
Organs/Tissues associated with PA2G4 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >15 publications with PA2G4 and Prostate
 Blood Antibodies  >10 publications with PA2G4 and Blood
 Muscle Antibodies  >5 publications with PA2G4 and Muscle
 Liver Antibodies  >4 publications with PA2G4 and Liver
 Salivary Gland Antibodies  >4 publications with PA2G4 and Salivary Gland
 Mouth Antibodies  >4 publications with PA2G4 and Mouth
 Lung Antibodies  >4 publications with PA2G4 and Lung
 Brain Antibodies  >4 publications with PA2G4 and Brain
 Embryonic Tissue Antibodies  >3 publications with PA2G4 and Embryonic Tissue
 Kidney Antibodies  >2 publications with PA2G4 and Kidney
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