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PAI-1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203116
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAI-1, Recombinant Protein

 Also Known As   

PAI-1, 24-402aa, Human, His tag, E Coli (Bioactivity Validated)

 Product Synonym Names    Plasminogen activator inhibitor-1; PLANH1; SERPINE1; PAI1; PLANH1; Plasminogen activator inhibitor-1; Plasminogen activator inhibitor-1
 Product Gene Name   

PAI-1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YTEFTTPDGH YYDILELPYH GDTLSMFIAA PYEKEVPLSA LTNILSAQLI SHWKGNMTRL PRLLVLPKFS LETEVDLRKP LENLGMTDMF RQFQADFTSL SDQEPLHVAQ ALQKVKIEVN ESGTVASSST AVIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP
 OMIM    X04429 mRNA
 3D Structure    ModBase 3D Structure for P05121
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 50mM NaAc (pH 5.5) containing 10% glycerol, 0.1M NaCl
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Biological Activity    The IC50 for this effect is less than 3 nM, Measured by its ability to inhibit uPA cleavage of the substrate Z-GGR-AMC.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PAI-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PAI-1 recombinant protein

   Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) super family. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, the activators of plasminogen and hence fibrinolysis. PAI-1 is mainly produced by the endothelium but is also secreted by other tissue types, such as adipose tissue. Recombinant human PAI-1, fused to His tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PAI-1 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for PAI-1 recombinant protein   

SDS-PAGE

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 SDS-Page of PAI-1 recombinant protein    PAI-1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PAI-1. It may not necessarily be applicable to this product.
 NCBI GI #    10835159
 NCBI GeneID    5054
 NCBI Accession #    NP_000593 [Other Products]
 NCBI GenBank Nucleotide #    NM_000602.4 [Other Products]
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 UniProt Primary Accession #    P05121 [Other Products]
 UniProt Secondary Accession #    B7Z4S0; F8WD53 [Other Products]
 UniProt Related Accession #    P05121 [Other Products]
 Molecular Weight    45 kDa (400 aa)
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 NCBI Official Full Name    plasminogen activator inhibitor 1
 NCBI Official Synonym Full Names    serpin family E member 1
 NCBI Official Symbol    SERPINE1 [Similar Products]
 NCBI Official Synonym Symbols   
PAI; PAI1; PAI-1; PLANH1
[Similar Products]
 NCBI Protein Information    plasminogen activator inhibitor 1
 UniProt Protein Name    Plasminogen activator inhibitor 1
 UniProt Synonym Protein Names   
Endothelial plasminogen activator inhibitor; Serpin E1
 UniProt Gene Name    SERPINE1 [Similar Products]
 UniProt Synonym Gene Names    PAI1; PLANH1; PAI; PAI-1 [Similar Products]
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 NCBI Summary for PAI-1    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for PAI-1    Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
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Product References and Citations for PAI-1 recombinant protein

   Gorlatova NV., et al. (2007) J Biol Chem. 282 (12):9288-96.; Renckens R., et al. (2006) J Immunol. 177 (11):8171-6.;
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 Research Articles on PAI-1    1. data suggest that even an isocaloric exchange of macronutrients - for example, a switch to a fat-rich diet - affects PAI-1 concentrations in humans and that this is highly heritable.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAI-1 recombinant proteinPathways associated with PAI-1 recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >76 publications with PAI-1 and TGFB1
 SMAD3 recombinant protein  >35 publications with PAI-1 and SMAD3
 VEGFA recombinant protein  >34 publications with PAI-1 and VEGFA
 PLAUR recombinant protein  >27 publications with PAI-1 and PLAUR
 PLAT recombinant protein  >17 publications with PAI-1 and PLAT
 PLAU recombinant protein  >15 publications with PAI-1 and PLAU
 VTN recombinant protein  >1 publications with PAI-1 and VTN
 PLG recombinant protein  >1 publications with PAI-1 and PLG
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 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
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 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
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 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
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Diseases associated with PAI-1 recombinant proteinOrgans/Tissues associated with PAI-1 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >391 publications with PAI-1 and Cardiovascular Diseases
 Inflammation Antibodies  >209 publications with PAI-1 and Inflammation
 Thrombosis Antibodies  >161 publications with PAI-1 and Thrombosis
 Obesity Antibodies  >115 publications with PAI-1 and Obesity
 Heart Diseases Antibodies  >112 publications with PAI-1 and Heart Diseases
 Fibrosis Antibodies  >112 publications with PAI-1 and Fibrosis
 Necrosis Antibodies  >108 publications with PAI-1 and Necrosis
 Atherosclerosis Antibodies  >93 publications with PAI-1 and Atherosclerosis
 Nervous System Diseases Antibodies  >89 publications with PAI-1 and Nervous System Diseases
 Hypertension Antibodies  >63 publications with PAI-1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >593 publications with PAI-1 and Blood
 Vascular Antibodies  >280 publications with PAI-1 and Vascular
 Lung Antibodies  >93 publications with PAI-1 and Lung
 Heart Antibodies  >86 publications with PAI-1 and Heart
 Connective Tissue Antibodies  >84 publications with PAI-1 and Connective Tissue
 Liver Antibodies  >70 publications with PAI-1 and Liver
 Adipose Tissue Antibodies  >60 publications with PAI-1 and Adipose Tissue
 Muscle Antibodies  >60 publications with PAI-1 and Muscle
 Kidney Antibodies  >57 publications with PAI-1 and Kidney
 Brain Antibodies  >55 publications with PAI-1 and Brain
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