NP_005434.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,833 Da
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Synonym Protein Names
Sulfurylase kinase 1; SK 1; SK1
UniProt Synonym Gene Names
UniProt Entry Name
PAPS1_HUMAN
NCBI Summary for PAPSS1
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
UniProt Comments for PAPSS1
PAPSS1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Protein type: EC 2.7.1.25; EC 2.7.7.4; Energy Metabolism - sulfur; Kinase, other; Nucleotide Metabolism - purine; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: cytosol
Molecular Function: adenylylsulfate kinase activity; nucleotidyltransferase activity; protein homodimerization activity; sulfate adenylyltransferase (ATP) activity
Biological Process: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; skeletal development; sulfate assimilation
Research Articles on PAPSS1
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Products associated with PAPSS1 recombinant protein
Pathways associated with PAPSS1 recombinant protein
Diseases associated with PAPSS1 recombinant protein
Organs/Tissues associated with PAPSS1 recombinant protein
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