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PDGF-BB recombinant protein

Scan QR to view Datasheet Catalog #    MBS355607 PDGF-BB recombinant protein
Unit / Price
0.01 mg  /  $245 +1 FREE 8GB USB
0.1 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGF-BB, Recombinant Protein

★Popular Item★
 Also Known As   

PDGF-BB Protein (Active)

 Product Gene Name   

PDGF-BB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 22; NC_000022.10 (39619685..39640957, complement). Location: 22q13.1
 OMIM    190040
 3D Structure    ModBase 3D Structure for P01127
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 Host    Pichia yeast
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 Form/Format    Lyophilized
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 Biological Activity    The ED50, calculated by the dose-dependant proliferation of murine BALB/c 3T3 cells is < 1 ng/ml corresponding to a specific activity of 1 × 106 IU/mg.
 Dimers    < 1% by SDS-PAGE
 Endotoxin Level    < 0.1 ng/ug (1 EU/ug) by LAL test
 Reconstitution    Reconstitute with sterile 18MΩ-cm H2O.
 Storage Buffer    Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
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 Preparation and Storage    Ship at 4 degree C. Upon receipt, store at -20 degree C or -80 degree C for 2 years. After reconstituting, it can store at 4 degree C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles
 Other Notes    Small volumes of PDGF-BB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PDGF-BB recombinant protein

   Recombinant human PDGF-BB protein with molecular weight 28 kDa.
 Applications Tested/Suitable for PDGF-BB recombinant protein   

HPLC, SDS-PAGE

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NCBI/Uniprot data below describe general gene information for PDGF-BB. It may not necessarily be applicable to this product.
 NCBI GI #    15451786
 NCBI GeneID    5155
 NCBI Accession #    NP_148937.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_033016.2 [Other Products]
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 UniProt Primary Accession #    P01127 [Other Products]
 UniProt Secondary Accession #    P78431; Q15354; Q6FHE7; Q9UF23; G3XAG8 [Other Products]
 UniProt Related Accession #    P01127 [Other Products]
 Molecular Weight    27,283 Da
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 NCBI Official Full Name    platelet-derived growth factor subunit B isoform 2 preproprotein
 NCBI Official Synonym Full Names    platelet-derived growth factor beta polypeptide
 NCBI Official Symbol    PDGFB [Similar Products]
 NCBI Official Synonym Symbols   
SIS; SSV; PDGF2; c-sis; PDGF-2
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
 UniProt Protein Name    Platelet-derived growth factor subunit B
 UniProt Synonym Protein Names   
PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis
 UniProt Gene Name    PDGFB [Similar Products]
 UniProt Synonym Gene Names    PDGF2; SIS; PDGF subunit B [Similar Products]
 UniProt Entry Name    PDGFB_HUMAN
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 NCBI Summary for PDGF-BB    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
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 UniProt Comments for PDGF-BB    Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA

By similarity.

Subunit structure: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1

By similarity. Ref.19 Ref.24

Subcellular location: Secreted. Note: Released by platelets upon wounding.

Tissue specificity: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. Ref.20

Involvement in disease: A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Ref.21

Pharmaceutical use: Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot ulcers.

Sequence similarities: Belongs to the PDGF/VEGF growth factor family.
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 Research Articles on PDGF-BB    1. The present study demonstrated that the PDGF-beta alpha-Syn transgenic mouse model presents with early and progressive accumulation of human alpha-Syn that is accompanied by motor deficits.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDGF-BB recombinant proteinPathways associated with PDGF-BB recombinant protein
 Reference Product  PubMed Publications
 PDGFRB recombinant protein  >646 publications with PDGF-BB and PDGFRB
 PDGFRA recombinant protein  >352 publications with PDGF-BB and PDGFRA
 SRC recombinant protein  >146 publications with PDGF-BB and SRC
 STAT3 recombinant protein  >43 publications with PDGF-BB and STAT3
 PDGFA recombinant protein  >28 publications with PDGF-BB and PDGFA
 AKT1 recombinant protein  >26 publications with PDGF-BB and AKT1
 THBS1 recombinant protein  >14 publications with PDGF-BB and THBS1
 PTEN recombinant protein  >10 publications with PDGF-BB and PTEN
 GRB2 recombinant protein  >10 publications with PDGF-BB and GRB2
 HRAS recombinant protein  >8 publications with PDGF-BB and HRAS
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 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
Diseases associated with PDGF-BB recombinant proteinOrgans/Tissues associated with PDGF-BB recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >692 publications with PDGF-BB and Neoplasms
 Fibrosis Antibodies  >217 publications with PDGF-BB and Fibrosis
 Atherosclerosis Antibodies  >182 publications with PDGF-BB and Atherosclerosis
 Inflammation Antibodies  >127 publications with PDGF-BB and Inflammation
 Necrosis Antibodies  >121 publications with PDGF-BB and Necrosis
 Hyperplasia Antibodies  >106 publications with PDGF-BB and Hyperplasia
 Kidney Diseases Antibodies  >95 publications with PDGF-BB and Kidney Diseases
 Liver Diseases Antibodies  >93 publications with PDGF-BB and Liver Diseases
 Hypertension Antibodies  >90 publications with PDGF-BB and Hypertension
 Heart Diseases Antibodies  >73 publications with PDGF-BB and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1143 publications with PDGF-BB and Vascular
 Blood Antibodies  >616 publications with PDGF-BB and Blood
 Kidney Antibodies  >212 publications with PDGF-BB and Kidney
 Embryonic Tissue Antibodies  >199 publications with PDGF-BB and Embryonic Tissue
 Lung Antibodies  >190 publications with PDGF-BB and Lung
 Brain Antibodies  >189 publications with PDGF-BB and Brain
 Liver Antibodies  >158 publications with PDGF-BB and Liver
 Heart Antibodies  >134 publications with PDGF-BB and Heart
 Mouth Antibodies  >93 publications with PDGF-BB and Mouth
 Pancreas Antibodies  >30 publications with PDGF-BB and Pancreas
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