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PDGF-BB recombinant protein

Scan QR to view Datasheet Catalog #    MBS506084 PDGF-BB recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $500 +1 FREE 8GB USB
0.5 mg  /  $2,225 +2 FREE 8GB USB
1 mg  /  $3,650 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGF-BB, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human PDGF-BB

 Product Synonym Names    Human PDGF-BB; Platelet Derived Growth Factor-BB; GDGF; ODGF
 Product Gene Name   

PDGF-BB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT
 OMIM    K01401
 3D Structure
   ModBase 3D Structure for P01127
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 Host    E Coli
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 Purity/Purification    Reducing and Non-Reducing SDS PAGE, >=95%
 Form/Format    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing
10 mM sodium phosphate, pH 7.5
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 Species    Human
 Bioactivity Assay    NR6R-3T3 Proliferation
 Bioactivity Acceptance Criteria ED50 (ng/mL)    20 ng/mL
 Bioactivity Acceptance Criteria (Units/mg)    5.0 x 10^4 units/mg
 Reconstitution    Sterile water at 0.1 mg/mL
 Acceptance Criteria LAL (EUs/ug)    <=1.00
 Monomer/Dimer    Dimer
 Endotoxin Level (kinetic LAL analysis)    Kinetic LAL, <=1 EUs/mug
 Biological Activity    BALB/c 3T3 cell proliferation, <=20 ng/mL; >= 5.0 x 10^4 units/mg
 Media Components    Luria Broth
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 Preparation and Storage    12 months from date of receipt when stored at -20 degree C to-80 degree C as supplied.
1 month when stored at 4 degree C after reconstituting as directed.
3 months when stored at -20 degree C to -80 degree C after reconstituting as directed.
 Other Notes    Small volumes of PDGF-BB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PDGF-BB recombinant protein

   Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-a, TGF-b and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-a and PDGFR-b.
NCBI/Uniprot data below describe general gene information for PDGF-BB. It may not necessarily be applicable to this product.
 NCBI GI #    4505681
 NCBI GeneID    5155
 NCBI Accession #    NP_002599.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002608.3 [Other Products]
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 UniProt Primary Accession #    P01127 [Other Products]
 UniProt Secondary Accession #    P78431; Q15354; Q6FHE7; Q9UF23; G3XAG8 [Other Products]
 UniProt Related Accession #    P01127 [Other Products]
 Molecular Weight    Dimer, 12.4/24.9 kDa (110/220 aa)
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 NCBI Official Full Name    platelet-derived growth factor subunit B isoform 1 preproprotein
 NCBI Official Synonym Full Names    platelet derived growth factor subunit B
 NCBI Official Symbol    PDGFB [Similar Products]
 NCBI Official Synonym Symbols   
SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit B
 UniProt Protein Name    Platelet-derived growth factor subunit B
 UniProt Synonym Protein Names   
PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; INN: Becaplermin
 UniProt Gene Name    PDGFB [Similar Products]
 UniProt Synonym Gene Names    PDGF2; SIS; PDGF subunit B [Similar Products]
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 NCBI Summary for PDGF-BB    This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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 UniProt Comments for PDGF-BB    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA ().
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 Research Articles on PDGF-BB    1. this study shows that the expression of PDGFB is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDGF-BB recombinant proteinPathways associated with PDGF-BB recombinant protein
 Reference Product  PubMed Publications
 PDGFRB recombinant protein  >636 publications with PDGF-BB and PDGFRB
 PDGFRA recombinant protein  >346 publications with PDGF-BB and PDGFRA
 COL1A1 recombinant protein  >92 publications with PDGF-BB and COL1A1
 THBS1 recombinant protein  >14 publications with PDGF-BB and THBS1
 HRAS recombinant protein  >8 publications with PDGF-BB and HRAS
 LRP1 recombinant protein  >6 publications with PDGF-BB and LRP1
 ART1 recombinant protein  >2 publications with PDGF-BB and ART1
 PDAP1 recombinant protein  >1 publications with PDGF-BB and PDAP1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
Diseases associated with PDGF-BB recombinant proteinOrgans/Tissues associated with PDGF-BB recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >682 publications with PDGF-BB and Neoplasms
 Fibrosis Antibodies  >211 publications with PDGF-BB and Fibrosis
 Atherosclerosis Antibodies  >180 publications with PDGF-BB and Atherosclerosis
 Inflammation Antibodies  >123 publications with PDGF-BB and Inflammation
 Necrosis Antibodies  >118 publications with PDGF-BB and Necrosis
 Hyperplasia Antibodies  >104 publications with PDGF-BB and Hyperplasia
 Kidney Diseases Antibodies  >94 publications with PDGF-BB and Kidney Diseases
 Hypertension Antibodies  >89 publications with PDGF-BB and Hypertension
 Liver Diseases Antibodies  >88 publications with PDGF-BB and Liver Diseases
 Heart Diseases Antibodies  >71 publications with PDGF-BB and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1121 publications with PDGF-BB and Vascular
 Blood Antibodies  >605 publications with PDGF-BB and Blood
 Kidney Antibodies  >210 publications with PDGF-BB and Kidney
 Embryonic Tissue Antibodies  >194 publications with PDGF-BB and Embryonic Tissue
 Lung Antibodies  >189 publications with PDGF-BB and Lung
 Brain Antibodies  >186 publications with PDGF-BB and Brain
 Liver Antibodies  >153 publications with PDGF-BB and Liver
 Heart Antibodies  >133 publications with PDGF-BB and Heart
 Mouth Antibodies  >93 publications with PDGF-BB and Mouth
 Pancreas Antibodies  >29 publications with PDGF-BB and Pancreas
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