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PDGFA recombinant protein :: PDGF Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232237 PDGFA recombinant protein
Unit / Price
0.01 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGF (PDGFA), Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN PDGF AA HOMODIMER

 Product Gene Name   

PDGFA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173430
 3D Structure    ModBase 3D Structure for P04085
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 Purity/Purification    >98% by SDS PAGE and N-terminal sequence analysis.
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 1.0mg/ml (lot specific)
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 Reconstitution    Reconstitute with 10ul of 10mM acetic acid. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of PDGFA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PDGFA recombinant protein

   Recombinant Human Platelet Derived Growth Factor (PDGF) is a potent mitogen, acting on cell types such as fibroblasts and smooth muscle cells.PDGF is a dimeric protein being composed of A and B chains. The dimer may be formed from AA, BB or AB chain combinations.
 Applications Tested/Suitable for PDGFA recombinant protein   

Functional Assays (FN)

 Application Notes for PDGFA recombinant protein    Functional Assays: Minimum Dilution: 0.2ng/ml; Maximum Dilution: 10ng/ml
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NCBI/Uniprot data below describe general gene information for PDGFA. It may not necessarily be applicable to this product.
 NCBI GI #    77695917
 NCBI GeneID    5154
 NCBI Accession #    NP_002598.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002607.5 [Other Products]
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 UniProt Primary Accession #    P04085 [Other Products]
 UniProt Secondary Accession #    B5BU73 [Other Products]
 UniProt Related Accession #    P04085 [Other Products]
 Molecular Weight    Protein Molecular Weight: 26.5kDa (250 amino acid sequence) [Similar Products]
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 NCBI Official Full Name    platelet-derived growth factor subunit A isoform 1 preproprotein
 NCBI Official Synonym Full Names    platelet-derived growth factor alpha polypeptide
 NCBI Official Symbol    PDGFA [Similar Products]
 NCBI Official Synonym Symbols   
PDGF1; PDGF-A
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit A; PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein
 UniProt Protein Name    Platelet-derived growth factor subunit A
 UniProt Synonym Protein Names   
PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
 Protein Family    Platelet-derived growth factor
 UniProt Gene Name    PDGFA [Similar Products]
 UniProt Synonym Gene Names    PDGF1; PDGF subunit A [Similar Products]
 UniProt Entry Name    PDGFA_HUMAN
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 NCBI Summary for PDGFA    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDGFA    PDGFA: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: Golgi membrane; extracellular space; cell surface; microvillus; endoplasmic reticulum lumen; extracellular region

Molecular Function: collagen binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding

Biological Process: skin development; extracellular matrix organization and biogenesis; wound healing; nerve growth factor receptor signaling pathway; negative chemotaxis; platelet-derived growth factor receptor signaling pathway; cell projection biogenesis; response to estradiol stimulus; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; platelet degranulation; regulation of smooth muscle cell migration; hair follicle development; positive regulation of MAPKKK cascade; cell-cell signaling; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to wounding; angiogenesis; inner ear development; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; response to drug; platelet activation; response to inorganic substance; response to retinoic acid; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; cell activation; organ morphogenesis; positive regulation of cell division; regulation of actin cytoskeleton organization and biogenesis; response to hypoxia; innate immune response; blood coagulation; actin cytoskeleton organization and biogenesis; alveolus development; positive regulation of DNA replication; positive regulation of cell migration
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 Research Articles on PDGFA    1. PDGFA is a SOX11 direct target gene upregulated in MCL cells whose inhibition impaired SOX11-enhanced in vitro angiogenic effects on endothelial cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDGFA recombinant proteinPathways associated with PDGFA recombinant protein
 Reference Product  PubMed Publications
 PDGFRA recombinant protein  >44 publications with PDGFA and PDGFRA
 PDGFB recombinant protein  >30 publications with PDGFA and PDGFB
 PDGFRB recombinant protein  >22 publications with PDGFA and PDGFRB
 EGFR recombinant protein  >10 publications with PDGFA and EGFR
 FLT1 recombinant protein  >2 publications with PDGFA and FLT1
 FGF1 recombinant protein  >2 publications with PDGFA and FGF1
 SP1 recombinant protein  >1 publications with PDGFA and SP1
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Diseases associated with PDGFA recombinant proteinOrgans/Tissues associated with PDGFA recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >23 publications with PDGFA and Carcinoma
 Adenocarcinoma Antibodies  >15 publications with PDGFA and Adenocarcinoma
 Inflammation Antibodies  >11 publications with PDGFA and Inflammation
 Fibrosis Antibodies  >9 publications with PDGFA and Fibrosis
 Disease Models, Animal Antibodies  >8 publications with PDGFA and Disease Models, Animal
 Brain Diseases Antibodies  >7 publications with PDGFA and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >7 publications with PDGFA and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >7 publications with PDGFA and Neoplasms, Experimental
 Mesothelioma Antibodies  >4 publications with PDGFA and Mesothelioma
 Pancreatic Neoplasms Antibodies  >4 publications with PDGFA and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with PDGFA and Liver
 Brain Antibodies  >10 publications with PDGFA and Brain
 Lung Antibodies  >10 publications with PDGFA and Lung
 Embryonic Tissue Antibodies  >9 publications with PDGFA and Embryonic Tissue
 Connective Tissue Antibodies  >7 publications with PDGFA and Connective Tissue
 Kidney Antibodies  >6 publications with PDGFA and Kidney
 Testis Antibodies  >5 publications with PDGFA and Testis
 Mouth Antibodies  >5 publications with PDGFA and Mouth
 Ovary Antibodies  >5 publications with PDGFA and Ovary
 Intestine Antibodies  >4 publications with PDGFA and Intestine
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