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PEDF recombinant protein

Scan QR to view Datasheet Catalog #    MBS539585 PEDF recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PEDF, Recombinant Protein

 Also Known As   

PEDF protein

 Product Synonym Names    EPC-1 protein; SerpinF1 protein; Pigment epithelium-derived factor protein
 Product Gene Name   

PEDF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of PEDF protein correspond ing to amino acids MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ PAHLTFPLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP
 OMIM    172860
 3D Structure    ModBase 3D Structure for P36955
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 Host    Human
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 Purity/Purification    > 90% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of PEDF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PEDF recombinant protein

   Purified recombinant Human PEDF protein
 Product Categories/Family for PEDF recombinant protein    Neuroscience
 Applications Tested/Suitable for PEDF recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for PEDF. It may not necessarily be applicable to this product.
 NCBI GI #    39725934
 NCBI GeneID    5176
 NCBI Accession #    NP_002606.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002615.5 [Other Products]
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 UniProt Primary Accession #    P36955 [Other Products]
 UniProt Secondary Accession #    Q13236; Q2TU83; Q96CT1; Q96R01; Q9BWA4; F1T092 [Other Products]
 UniProt Related Accession #    P36955 [Other Products]
 Molecular Weight    44.5 kDa
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 NCBI Official Full Name    pigment epithelium-derived factor
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
 NCBI Official Symbol    SERPINF1 [Similar Products]
 NCBI Official Synonym Symbols   
OI6; OI12; PEDF; EPC-1; PIG35
[Similar Products]
 NCBI Protein Information    pigment epithelium-derived factor
 UniProt Protein Name    Pigment epithelium-derived factor
 UniProt Synonym Protein Names   
Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1
 UniProt Gene Name    SERPINF1 [Similar Products]
 UniProt Synonym Gene Names    PEDF; PEDF [Similar Products]
 UniProt Entry Name    PEDF_HUMAN
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 NCBI Summary for PEDF    The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
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 UniProt Comments for PEDF    PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; extracellular region; melanosome; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: cell proliferation; positive regulation of neurogenesis; negative regulation of angiogenesis; ovulation cycle; retina development in camera-type eye; short-term memory; response to arsenic; negative regulation of inflammatory response; multicellular organismal development; response to acidity; kidney development; aging

Disease: Osteogenesis Imperfecta, Type Vi
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 Research Articles on PEDF    1. PEDF inhibited breast cancer cell migration and invasion by down-regulating fibronectin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PEDF recombinant proteinDiseases associated with PEDF recombinant protein
 Reference Product  PubMed Publications
 VEGFA recombinant protein  >2 publications with PEDF and VEGFA
 Disease Name  Pubmed Publications
 Nerve Degeneration Antibodies  >1 publications with PEDF and Nerve Degeneration
 Brain Diseases Antibodies  >1 publications with PEDF and Brain Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with PEDF and Urinary Bladder Neoplasms
 Proteinuria Antibodies  >1 publications with PEDF and Proteinuria
 Lung Neoplasms Antibodies  >1 publications with PEDF and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with PEDF and Cell Transformation, Neoplastic
 Weight Loss Antibodies  >1 publications with PEDF and Weight Loss
Organs/Tissues associated with PEDF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >24 publications with PEDF and Bone
 Nerve Antibodies  >23 publications with PEDF and Nerve
 Eye Antibodies  >21 publications with PEDF and Eye
 Connective Tissue Antibodies  >10 publications with PEDF and Connective Tissue
 Skin Antibodies  >7 publications with PEDF and Skin
 Blood Antibodies  >7 publications with PEDF and Blood
 Adipose Tissue Antibodies  >5 publications with PEDF and Adipose Tissue
 Brain Antibodies  >5 publications with PEDF and Brain
 Embryonic Tissue Antibodies  >3 publications with PEDF and Embryonic Tissue
 Heart Antibodies  >2 publications with PEDF and Heart
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