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PELI2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS205987
SDS-Page
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PELI2, Recombinant Protein

★Popular Item★
 Also Known As   

PELI2, 1-420aa, Human, His tag, E Coli

 Product Synonym Names    E3 ubiquitin-protein ligase pellino homolog 2; PELI2 - pellino E3; Pellino-2
 Product Gene Name   

PELI2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSMFSPGQE EHCAPNKEPV KYGELVVLGY NGALPNGDRG RRKSRFALYK RPKANGVKPS TVHVISTPQA SKAISCKGQH SISYTLSRNQ TVVVEYTHDK DTDMFQVGRS TESPIDFVVT DTISGSQNTD EAQITQSTIS RFACRIVCDR NEPYTARIFA AGFDSSKNIF LGEKAAKWKN PDGHMDGLTT NGVLVMHPRG GFTEESQPGV WREISVCGDV YTLRETRSAQ QRGKLVESET NVLQDGSLID LCGATLLWRT ADGLFHTPTQ KHIEALRQEI NAARPQCPVG LNTLAFPSIN RKEVVEEKQP WAYLSCGHVH GYHNWGHRSD TEANERECPM CRTVGPYVPL WLGCEAGFYV DAGPPTHAFT PCGHVCSEKS AKYWSQIPLP HGTHAFHAAC PFCATQLVGE QNCIKLIFQG PID
 OMIM    AF302502 mRNA
 3D Structure    ModBase 3D Structure for Q9HAT8
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 Host    E Coli
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 Purity/Purification    > 80% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PELI2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PELI2 recombinant protein

   PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. It can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Recombinant human PELI2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PELI2 recombinant protein    Signal Transduction
 Applications Tested/Suitable for PELI2 recombinant protein   

SDS-PAGE

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 SDS-Page of PELI2 recombinant protein    PELI2 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PELI2. It may not necessarily be applicable to this product.
 NCBI GI #    10864063
 NCBI GeneID    57161
 NCBI Accession #    NP_067078 [Other Products]
 NCBI GenBank Nucleotide #    NM_021255.2 [Other Products]
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 UniProt Primary Accession #    Q9HAT8 [Other Products]
 UniProt Secondary Accession #    B2RDY5 [Other Products]
 UniProt Related Accession #    Q9HAT8 [Other Products]
 Molecular Weight    48.8 kDa (443aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    E3 ubiquitin-protein ligase pellino homolog 2
 NCBI Official Synonym Full Names    pellino E3 ubiquitin protein ligase family member 2
 NCBI Official Symbol    PELI2 [Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase pellino homolog 2
 UniProt Protein Name    E3 ubiquitin-protein ligase pellino homolog 2
 UniProt Synonym Protein Names   
RING-type E3 ubiquitin transferase pellino homolog 2Curated
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    PELI2 [Similar Products]
 UniProt Synonym Gene Names    Pellino-2 [Similar Products]
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 UniProt Comments for PELI2    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
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Product References and Citations for PELI2 recombinant protein

   Jensen L.E., et al (2003). FEBS Lett. 545:199-202; Strelow A., et al (2003). FEBS Lett. 547:157-161
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 Research Articles on PELI2    1. A high-affinity Pellino2 e3 ubiquitin ligase binding domain is specific for phosphothreonine motifs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PELI2 recombinant proteinPathways associated with PELI2 recombinant protein
 Reference Product  PubMed Publications
 PELI1 recombinant protein  >5 publications with PELI2 and PELI1
 IRAK1 recombinant protein  >4 publications with PELI2 and IRAK1
 IKBKB recombinant protein  >1 publications with PELI2 and IKBKB
 IRAK4 recombinant protein  >1 publications with PELI2 and IRAK4
 TRAF6 recombinant protein  >1 publications with PELI2 and TRAF6
 MYD88 recombinant protein  >1 publications with PELI2 and MYD88
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IRAK1 Recruits IKK Complex Pathway antibodies  IRAK1 Recruits IKK Complex Pathway Diagram
 IRAK1 Recruits IKK Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK1 Recruits IKK Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
Diseases associated with PELI2 recombinant proteinOrgans/Tissues associated with PELI2 recombinant protein
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >1 publications with PELI2 and Hypertension
 Necrosis Antibodies  >1 publications with PELI2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >2 publications with PELI2 and Bone Marrow
 Blood Antibodies  >1 publications with PELI2 and Blood
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